دورية أكاديمية
Differential proliferation regulates multi-tissue morphogenesis during embryonic axial extension: integrating viscous modeling and experimental approaches.
| العنوان: | Differential proliferation regulates multi-tissue morphogenesis during embryonic axial extension: integrating viscous modeling and experimental approaches. |
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| المؤلفون: | Romanos M; Molecular, Cellular and Developmental Biology Unit (MCD, UMR 5077), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 31062 Toulouse, France.; Institut de Mathématiques de Toulouse UMR 5219, Université de Toulouse, CNRS, 31062 Toulouse Cedex 9, France.; Université Claude Bernard Lyon 1, CNRS, Ecole Centrale de Lyon, INSA Lyon, Université Jean Monnet, ICJ UMR5208, 69622 Villeurbanne, France., Salisbury T; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.; University of Southern California, Los Angeles, CA 90089, USA., Stephan S; Molecular, Cellular and Developmental Biology Unit (MCD, UMR 5077), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 31062 Toulouse, France., Lansford R; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.; University of Southern California, Los Angeles, CA 90089, USA., Degond P; Institut de Mathématiques de Toulouse UMR 5219, Université de Toulouse, CNRS, 31062 Toulouse Cedex 9, France., Trescases A; Institut de Mathématiques de Toulouse UMR 5219, Université de Toulouse, CNRS, 31062 Toulouse Cedex 9, France., Bénazéraf B; Molecular, Cellular and Developmental Biology Unit (MCD, UMR 5077), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 31062 Toulouse, France. |
| المصدر: | Development (Cambridge, England) [Development] 2024 Jul 01; Vol. 151 (13). Date of Electronic Publication: 2024 Jul 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge Eng : Company Of Biologists Limited Original Publication: [Cambridge] : Company of Biologists, [c1987- |
| مواضيع طبية MeSH: | Morphogenesis* , Cell Proliferation* , Mesoderm*/embryology , Mesoderm*/cytology , Neural Tube*/embryology , Neural Tube*/cytology , Models, Biological*, Animals ; Quail/embryology ; Embryo, Nonmammalian/cytology ; Embryonic Development/physiology ; Viscosity |
| مستخلص: | A major challenge in biology is to understand how mechanical interactions and cellular behavior affect the shapes of tissues and embryo morphology. The extension of the neural tube and paraxial mesoderm, which form the spinal cord and musculoskeletal system, respectively, results in the elongated shape of the vertebrate embryonic body. Despite our understanding of how each of these tissues elongates independently of the others, the morphogenetic consequences of their simultaneous growth and mechanical interactions are still unclear. Our study investigates how differential growth, tissue biophysical properties and mechanical interactions affect embryonic morphogenesis during axial extension using a 2D multi-tissue continuum-based mathematical model. Our model captures the dynamics observed in vivo by time-lapse imaging of bird embryos, and reveals the underestimated influence of differential tissue proliferation rates. We confirmed this prediction in quail embryos by showing that decreasing the rate of cell proliferation in the paraxial mesoderm affects long-term tissue dynamics, and shaping of both the paraxial mesoderm and the neighboring neural tube. Overall, our work provides a new theoretical platform upon which to consider the long-term consequences of tissue differential growth and mechanical interactions on morphogenesis. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2024. Published by The Company of Biologists Ltd.) |
| معلومات مُعتمدة: | Centre National de la Recherche Scientifique; Université de Toulouse; Région Occitanie Pyrénées-Méditerranée; Fondation pour la Recherche Médicale |
| فهرسة مساهمة: | Keywords: Axial elongation; Bird embryo; Continuum modeling; Differential proliferation; Inter-tissue mechanics; Morphogenesis |
| تواريخ الأحداث: | Date Created: 20240610 Date Completed: 20240704 Latest Revision: 20240704 |
| رمز التحديث: | 20240704 |
| DOI: | 10.1242/dev.202836 |
| PMID: | 38856082 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1477-9129 |
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| DOI: | 10.1242/dev.202836 |