A New Capillary-Channel Agarose Sponge Assembled with Deep Eutectic Solvent Based Magnetic Fluid for Rapid Hemostasis and Prevention of Bacterial Infection.

التفاصيل البيبلوغرافية
العنوان:	A New Capillary-Channel Agarose Sponge Assembled with Deep Eutectic Solvent Based Magnetic Fluid for Rapid Hemostasis and Prevention of Bacterial Infection.
المؤلفون:	Guo Y; School of Chemical Engineering, Sichuan University, Chengdu 610065, China.; School of Pharmacy, Chengdu Medical College, Chengdu 610500, China., Li Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China., Chen Y; South Sichuan Institute of Translational Medicine, School of Pharmacy, Southwest Medical University, Luzhou 646000, China., Ali A; School of Chemical Engineering, Sichuan University, Chengdu 610065, China., Yao S; School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
المصدر:	ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Jun 19; Vol. 16 (24), pp. 30874-30889. Date of Electronic Publication: 2024 Jun 10.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Washington, D.C. : American Chemical Society
مواضيع طبية MeSH:	Sepharose/chemistry , Staphylococcus aureus/drug effects , Escherichia coli*/drug effects, Animals ; Rats ; Solvents/chemistry ; Hemostasis/drug effects ; Polymers/chemistry ; Polymers/pharmacology ; Indoles/chemistry ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Hemostatics/chemistry ; Hemostatics/pharmacology ; Magnetic Fields ; Male ; Rats, Sprague-Dawley
مستخلص:	A new composite sponge assisted by magnetic field-mediated guidance was developed for effective hemostasis. It was based on polydopamine capillary-channel agarose (PDA-CAGA) sponge as matrix; meanwhile, the combination of deep eutectic solvent (DES, choline chloride:glycerol = 1:1, M/M)-dispersed Fe 3 O 4 nanoparticles after fabrication by tannic acid (DES-Fe 3 O 4 @TA) was applied as hemostatic magnetic fluid. This sponge had oriented and aligned capillary channels realized by a 3D printed pattern, which endowed them with obvious shape memory and liquid absorption performance. Computational simulation was performed to describe the fluid status in channels; DES-Fe 3 O 4 @TA exhibited good magnetic properties, fluidity, and stability. In addition, the sponge driven to react rapidly with the bleeding site under the effect of a magnetic field presented a shorter hemostasis time (reduced by 85.02% in the tail and 81.07% in the liver of rats) and less blood loss (reduced by 97.08% in the tail and 91.50% in the liver) than those of medical gelatin sponge (GS). Meanwhile, the multifunctional material also exhibited better biocompatibility, procoagulant performance, and significant inhibition on S. aureus and E. coli than GS. As a whole, this work proposed a new strategy for rapid hemostasis by designing a magnetic field assisted composite bacteriostatic material, which also expanded the applications of green solvents in the clinical management field.
فهرسة مساهمة:	Keywords: Agarose sponge; Capillary-channel; Deep eutectic solvents; Magnetic fluid; Multiple properties
المشرفين على المادة:	9012-36-6 (Sepharose) 0 (Solvents) 0 (polydopamine) 0 (Polymers) 0 (Indoles) 0 (Anti-Bacterial Agents) 0 (Hemostatics)
تواريخ الأحداث:	Date Created: 20240610 Date Completed: 20240621 Latest Revision: 20240621
رمز التحديث:	20240621
DOI:	10.1021/acsami.4c04879
PMID:	38856922
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1944-8252
DOI:	10.1021/acsami.4c04879