دورية أكاديمية
أعرض في EDS

Obese mice have decreased uterine contractility and altered energy metabolism in the uterus at term gestation†.

التفاصيل البيبلوغرافية
العنوان: Obese mice have decreased uterine contractility and altered energy metabolism in the uterus at term gestation†.
المؤلفون: Prifti KK; Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA., McCarthy R; Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA., Ma X; Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA., Finck BN; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO, USA., England SK; Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA., Frolova AI; Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA.
المصدر: Biology of reproduction [Biol Reprod] 2024 Sep 14; Vol. 111 (3), pp. 678-693.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0207224 Publication Model: Print Cited Medium: Internet ISSN: 1529-7268 (Electronic) Linking ISSN: 00063363 NLM ISO Abbreviation: Biol Reprod Subsets: MEDLINE
أسماء مطبوعة: Publication: 2017- : New York : Oxford University Press
Original Publication: Champaign, Ill. : Society for the Study of Reproduction
مواضيع طبية MeSH: Energy Metabolism*/physiology , Uterine Contraction*/physiology , Uterus*/metabolism, Female ; Animals ; Mice ; Pregnancy ; Obesity/metabolism ; Obesity/physiopathology ; Mice, Obese ; Myometrium/metabolism ; Dystocia/metabolism ; Dystocia/physiopathology ; Mice, Inbred C57BL
مستخلص: Over 35% of reproductive-age women in the USA have obesity, putting them at increased risk for numerous obstetric complications due to abnormal labor. While the association between maternal obesity and abnormal labor has been well documented, the mechanisms responsible for this remain understudied. The uterine smooth muscle, myometrium, has high energy needs in order to fuel regular uterine contractions during parturition. However, the precise mechanisms by which the myometrium meets its energy demands has not been defined. Here, our objective was to define the effects of obesity on energy utilization in the myometrium during labor. We generated a mouse model of maternal diet-induced obesity and found that these mice had a higher rate of dystocia than control chow-fed mice. Moreover, compared to control chow-fed mice, DIO mice at term, both before and during labor had lower in vivo spontaneous uterine contractility. Untargeted transcriptomic and metabolomic analyses suggest that diet-induced obesity is associated with elevated long-chain fatty acid uptake and utilization in the uterus, but also an accumulation of medium-chain fatty acids. Diet-induced obesity uteri also had an increase in the abundance of long chain-specific beta-oxidation enzymes, which may be responsible for the observed increase in long-chain fatty acid utilization. This altered energy substrate utilization may be a contributor to the observed contractile dysfunction.
(© The Author(s) 2024. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
References: Eur J Biochem. 2004 Feb;271(3):462-9. (PMID: 14728673)
Diabetes. 2001 Jun;50(6):1389-96. (PMID: 11375340)
Eur J Obstet Gynecol Reprod Biol. 2005 Sep 1;122(1):49-56. (PMID: 16154039)
Reproduction. 2017 May;153(5):565-576. (PMID: 28400465)
Biochem J. 2009 Mar 1;418(2):261-75. (PMID: 19196246)
Endocrinology. 1957 Jan;60(1):33-7. (PMID: 13384381)
Am J Obstet Gynecol. 2010 Sep;203(3):264.e1-7. (PMID: 20673867)
Hum Reprod. 1999 Jan;14(1):229-36. (PMID: 10374126)
Curr Opin Clin Nutr Metab Care. 2023 Jul 1;26(4):323-329. (PMID: 37144457)
Nucleic Acids Res. 2022 Jul 5;50(W1):W216-W221. (PMID: 35325185)
Metabolism. 2000 Apr;49(4):467-72. (PMID: 10778870)
Am J Obstet Gynecol. 2018 Jan;218(1):122.e1-122.e8. (PMID: 29138035)
Biol Reprod. 2018 Nov 1;99(5):922-937. (PMID: 29733339)
Cardiovasc Res. 1997 Feb;33(2):243-57. (PMID: 9074687)
Physiol Rep. 2023 Mar;11(5):e15610. (PMID: 36863718)
J Physiol. 2017 Dec 1;595(23):7109-7122. (PMID: 29119568)
Nucleic Acids Res. 2002 Jan 1;30(1):207-10. (PMID: 11752295)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Sci Rep. 2018 Jun 6;8(1):8691. (PMID: 29875472)
Diabetes. 2018 May;67(5):885-897. (PMID: 29436377)
Teratology. 1988 Jan;37(1):63-7. (PMID: 3347909)
FEBS Lett. 1986 Nov 10;208(1):59-62. (PMID: 2429868)
Circ Res. 2003 Sep 5;93(5):448-55. (PMID: 12893739)
BMC Pregnancy Childbirth. 2007 Jun 01;7 Suppl 1:S7. (PMID: 17570167)
Endocr Rev. 2007 Feb;28(1):48-83. (PMID: 17018838)
Pediatr Clin North Am. 2018 Apr;65(2):317-335. (PMID: 29502916)
JAMA. 2016 Jun 7;315(21):2284-91. (PMID: 27272580)
Obstet Gynecol. 2012 Jul;120(1):130-5. (PMID: 22914401)
Obes Rev. 2008 Nov;9(6):635-83. (PMID: 18673307)
BJOG. 2007 Mar;114(3):343-8. (PMID: 17261121)
BMC Bioinformatics. 2006 Mar 09;7:123. (PMID: 16526949)
Sci Rep. 2017 Dec 13;7(1):17528. (PMID: 29235526)
J Vis Exp. 2015 Apr 06;(98):e52541. (PMID: 25867820)
J Inherit Metab Dis. 2010 Oct;33(5):469-77. (PMID: 20195903)
Gynecol Obstet Invest. 1999;47(3):166-71. (PMID: 10087410)
Circ Res. 2007 Aug 17;101(4):335-47. (PMID: 17702980)
Cell Metab. 2017 May 2;25(5):1027-1036. (PMID: 28467922)
Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1009-17. (PMID: 18765680)
Obstet Gynecol. 2010 Dec;116(6):1281-1287. (PMID: 21099592)
Am J Perinatol. 2018 Jan;35(1):59-64. (PMID: 28800658)
Obesity (Silver Spring). 2021 Oct;29(10):1582-1595. (PMID: 34464025)
J Appl Physiol (1985). 2007 Jun;102(6):2369-78. (PMID: 17317875)
Am J Obstet Gynecol. 2011 Aug;205(2):128.e1-7. (PMID: 21621187)
Reprod Biol Endocrinol. 2015 Dec 18;13:135. (PMID: 26684329)
Bioinformatics. 2004 Jan 1;20(1):93-9. (PMID: 14693814)
BMC Pregnancy Childbirth. 2012 Oct 18;12:112. (PMID: 23078042)
Eur J Obstet Gynecol Reprod Biol. 1995 Oct;62(2):241-5. (PMID: 8582504)
Am J Perinatol. 2011 Oct;28(9):729-34. (PMID: 21660900)
Reprod Biol Endocrinol. 2011 Mar 21;9:35. (PMID: 21418633)
Cell Death Dis. 2021 Feb 12;12(2):176. (PMID: 33579894)
Proc Natl Acad Sci U S A. 1987 Jun;84(12):4068-72. (PMID: 3035565)
N Engl J Med. 2022 Jul 21;387(3):248-259. (PMID: 35857661)
Biol Reprod. 2012 Feb 14;86(2):39. (PMID: 22011391)
J Bone Miner Res. 2014;29(5):1025-40. (PMID: 24585709)
Nutrients. 2020 Oct 22;12(11):. (PMID: 33105762)
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5. (PMID: 12883005)
Life (Basel). 2022 May 26;12(6):. (PMID: 35743826)
Biol Res Nurs. 2020 Apr;22(2):157-168. (PMID: 31983215)
Clin Sci (Lond). 2016 Feb;130(3):183-92. (PMID: 26543049)
Annu Rev Physiol. 1974;36:413-59. (PMID: 19400669)
PLoS One. 2010 Aug 25;5(8):e12418. (PMID: 20811634)
JCI Insight. 2018 Jun 7;3(11):. (PMID: 29875324)
معلومات مُعتمدة: Genome Technology Access Center at the McDonnell Genome Institute at Washington University School of Medicine; R01 HD037831 United States HD NICHD NIH HHS; P30 CA091842 United States CA NCI NIH HHS; United States NH NIH HHS; UL1 TR002345 United States TR NCATS NIH HHS; R21 HD110610 United States HD NICHD NIH HHS; P30 CA91842 NCI Cancer Center; Siteman Cancer Center; UL1TR002345 ICTS/CTSA
فهرسة مساهمة: Keywords: contractility; fatty acids; metabolism; obesity; parturition
تواريخ الأحداث: Date Created: 20240610 Date Completed: 20240915 Latest Revision: 20240917
رمز التحديث: 20240917
مُعرف محوري في PubMed: PMC11402524
DOI: 10.1093/biolre/ioae086
PMID: 38857377
قاعدة البيانات: MEDLINE
الوصف
تدمد:1529-7268
DOI:10.1093/biolre/ioae086