دورية أكاديمية
Development and Characterization of Quercetin-Loaded Polymeric Liposomes with Gelatin-Poly(ethylene glycol)-Folic Acid Coating to Increase Their Long-Circulating and Anticancer Activity.
| العنوان: | Development and Characterization of Quercetin-Loaded Polymeric Liposomes with Gelatin-Poly(ethylene glycol)-Folic Acid Coating to Increase Their Long-Circulating and Anticancer Activity. |
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| المؤلفون: | Nguyen-Huu AM; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam.; Department of Chemical and Material Engineering, Vlab, New Jersey Institute of Technology, Newark, New Jersey 07001, United States., Le NTT; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi City 100000, Vietnam., Vo Do MH; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam., Dong Yen PN; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam., Nguyen-Dinh TD; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi City 100000, Vietnam., Nguyen NH; Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi City 100000, Vietnam., Nguyen DH; Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi City 100000, Vietnam. |
| المصدر: | ACS applied bio materials [ACS Appl Bio Mater] 2024 Jul 15; Vol. 7 (7), pp. 4454-4470. Date of Electronic Publication: 2024 Jun 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : ACS Publications, [2018]- |
| مواضيع طبية MeSH: | Liposomes*/chemistry , Polyethylene Glycols*/chemistry , Gelatin*/chemistry , Folic Acid*/chemistry , Folic Acid*/analogs & derivatives , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/administration & dosage , Quercetin*/chemistry , Quercetin*/pharmacology , Quercetin*/administration & dosage , Particle Size* , Materials Testing* , Cell Survival*/drug effects , Drug Screening Assays, Antitumor*, Humans ; MCF-7 Cells ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Biocompatible Materials/chemical synthesis ; Cell Proliferation/drug effects ; Molecular Structure |
| مستخلص: | Liposomes as drug-delivery systems have been researched and applied in multiple scientific reports and introduced as patented products with interesting therapeutic properties. Despite various advantages, this drug carrier faces major difficulties in its innate stability, cancer cell specificity, and control over the release of hydrophobic drugs, particularly quercetin, a naturally derived drug that carries many desirable characteristics for anticancer treatment. To improve the effectiveness of liposomes to deliver quercetin by tackling and mitigating the mentioned hurdles, we developed a strategy to establish the ability to passively target cancerous cells, as well as to increase the bioavailability of loaded drugs by incorporating poly(ethylene glycol), gelatin, and folic acid moieties to modify the liposomal system's surface. This research developed a chemically synthesized gelatin, poly(ethylene glycol), and folic acid as a single polymer to coat drug-loaded liposome systems. Liposomes were coated with gelatin-poly(ethylene glycol)-folic acid by electrostatic interaction, characterized by their size, morphology, ζ potential, drug loading efficiency, infrared structures, differential scanning calorimetry spectra, and drug-releasing profiles, and then evaluated for their cytotoxicity to MCF-7 breast cancer cells, as well as cellular uptake, analyzed by confocal imaging to further elaborate on the in vitro behavior of the coated liposome. The results indicated an unusual change in size with increased coating materials, followed by increased colloidal stability, ζ potential, and improved cytotoxicity to cancer cells, as shown by the cellular viability test with MCF-7. Cellular uptake also confirmed these results, providing data for the effects of biopolymer coating, while confirming that folic acid can increase the uptake of liposome by cancer cells. In consideration of such results, the modified gelatin-poly(ethylene glycol)-folic acid-coated liposome can be a potential system in delivering the assigned anticancer compound. This modified biopolymer showed excellent properties as a coating material and should be considered for further practical applications in the future. |
| فهرسة مساهمة: | Keywords: drug delivery; folic acid; gelatin; poly(ethylene glycol); polymeric liposome; quercetin |
| المشرفين على المادة: | 0 (Liposomes) 3WJQ0SDW1A (Polyethylene Glycols) 9000-70-8 (Gelatin) 935E97BOY8 (Folic Acid) 0 (Antineoplastic Agents) 9IKM0I5T1E (Quercetin) 0 (Biocompatible Materials) 0 (poly(ethylene glycol)-folate) |
| تواريخ الأحداث: | Date Created: 20240610 Date Completed: 20240715 Latest Revision: 20240715 |
| رمز التحديث: | 20240715 |
| DOI: | 10.1021/acsabm.4c00334 |
| PMID: | 38857443 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 2576-6422 |
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| DOI: | 10.1021/acsabm.4c00334 |