دورية أكاديمية
أعرض في EDS

Whey protein-loaded 3D-printed poly (lactic) acid scaffolds for wound dressing applications.

التفاصيل البيبلوغرافية
العنوان: Whey protein-loaded 3D-printed poly (lactic) acid scaffolds for wound dressing applications.
المؤلفون: Kayadurmus HM; Centre for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Metallurgical & Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey., Rezaei A; UCL Division of Surgery & Interventional Science, University College London, 9th Floor Royal Free Hospital, London NW3 2QG, United Kingdom., Ilhan E; Centre for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey., Cesur S; Centre for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Metallurgical & Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey., Sahin A; Department of Biochemistry, School of Medicine/Genetic and Metabolic Diseases Research and Investigation Centre, Marmara University, Istanbul, Turkey., Gunduz O; Centre for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Metallurgical & Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey., Kalaskar DM; UCL Division of Surgery & Interventional Science, University College London, 9th Floor Royal Free Hospital, London NW3 2QG, United Kingdom., Ekren N; Centre for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Electrical and Electronics Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey.
المصدر: Biomedical materials (Bristol, England) [Biomed Mater] 2024 Jun 28; Vol. 19 (4). Date of Electronic Publication: 2024 Jun 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Institute of Physics Pub Country of Publication: England NLM ID: 101285195 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-605X (Electronic) Linking ISSN: 17486041 NLM ISO Abbreviation: Biomed Mater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bristol, UK : Institute of Physics Pub.,
مواضيع طبية MeSH: Whey Proteins*/chemistry , Polyesters*/chemistry , Printing, Three-Dimensional* , Tissue Scaffolds*/chemistry , Wound Healing*/drug effects , Bandages* , Tensile Strength* , Biocompatible Materials*/chemistry, Humans ; Materials Testing ; Spectroscopy, Fourier Transform Infrared ; Microscopy, Electron, Scanning ; Cell Survival/drug effects ; Porosity ; Drug Liberation ; Skin/metabolism
مستخلص: Chronic skin wounds pose a global clinical challenge, necessitating effective treatment strategies. This study explores the potential of 3D printed Poly Lactic Acid (PLA) scaffolds, enhanced with Whey Protein Concentrate (WPC) at varying concentrations (25, 35, and 50% wt), for wound healing applications. PLA's biocompatibility, biodegradability, and thermal stability make it an ideal material for medical applications. The addition of WPC aims to mimic the skin's extracellular matrix and enhance the bioactivity of the PLA scaffolds. Fourier Transform Infrared Spectroscopy results confirmed the successful loading of WPC into the 3D printed PLA-based scaffolds. Scanning Electron Microscopy (SEM) images revealed no significant differences in pore size between PLA/WPC scaffolds and pure PLA scaffolds. Mechanical strength tests showed similar tensile strength between pure PLA and PLA with 50% WPC scaffolds. However, scaffolds with lower WPC concentrations displayed reduced tensile strength. Notably, all PLA/WPC scaffolds exhibited increased strain at break compared to pure PLA. Swelling capacity was highest in PLA with 25% WPC, approximately 130% higher than pure PLA. Scaffolds with higher WPC concentrations also showed increased swelling and degradation rates. Drug release was found to be prolonged with increasing WPC concentration. After seven days of incubation, cell viability significantly increased in PLA with 50% WPC scaffolds compared to pure PLA scaffolds. This innovative approach could pave the way for personalized wound care strategies, offering tailored treatments and targeted drug delivery. However, further studies are needed to optimize the properties of these scaffolds and validate their effectiveness in clinical settings.
(Creative Commons Attribution license.)
فهرسة مساهمة: Keywords: 3D printing; tissue engineering scaffolds; whey protein concentrate; wound healing
المشرفين على المادة: 0 (Whey Proteins)
0 (Polyesters)
459TN2L5F5 (poly(lactide))
0 (Biocompatible Materials)
تواريخ الأحداث: Date Created: 20240610 Date Completed: 20240628 Latest Revision: 20240628
رمز التحديث: 20240628
DOI: 10.1088/1748-605X/ad565d
PMID: 38857605
قاعدة البيانات: MEDLINE
الوصف
تدمد:1748-605X
DOI:10.1088/1748-605X/ad565d