دورية أكاديمية
Alginate-containing 3D-printed hydrogel scaffolds incorporated with strontium promotes vascularization and bone regeneration.
| العنوان: | Alginate-containing 3D-printed hydrogel scaffolds incorporated with strontium promotes vascularization and bone regeneration. |
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| المؤلفون: | Miao A; Department of Orthopaedics, Taizhou People's Hospital, Taizhou, Jiangsu, China; Affiliated Taizhou People's Hospital of Nanjing Medical University, Jiangsu, China., Li Q; Department of Orthopaedics, Taizhou People's Hospital, Taizhou, Jiangsu, China; Affiliated Taizhou People's Hospital of Nanjing Medical University, Jiangsu, China., Tang G; Department of Orthopaedics, Taizhou People's Hospital, Taizhou, Jiangsu, China; Affiliated Taizhou People's Hospital of Nanjing Medical University, Jiangsu, China., Lu Q; Department of Orthopaedics, Taizhou People's Hospital, Taizhou, Jiangsu, China; Affiliated Taizhou People's Hospital of Nanjing Medical University, Jiangsu, China. Electronic address: tzlqf62@163.com. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2024 Jul; Vol. 273 (Pt 1), pp. 133038. Date of Electronic Publication: 2024 Jun 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Strontium*/chemistry , Strontium*/pharmacology , Printing, Three-Dimensional* , Tissue Scaffolds*/chemistry , Alginates*/chemistry , Alginates*/pharmacology , Bone Regeneration*/drug effects , Hydrogels*/chemistry , Hydrogels*/pharmacology , Osteogenesis*/drug effects, Animals ; Tissue Engineering/methods ; Neovascularization, Physiologic/drug effects ; Humans ; Cell Proliferation/drug effects ; Cell Survival/drug effects |
| مستخلص: | Bone defects persist as a significant challenge in the field of clinical orthopedics. This study focuses on the fabrication and characterization of 3D-printed composite hydrogel scaffolds composed of sodium alginate, gelatin, and α-tricalcium phosphate (α-TCP) with varying ratios of Strontium ions (Sr 2+ ). These scaffolds aim to address the clinical challenges associated with bone defect repair by providing mechanical support and promoting bone formation and vascularization. The degradation, swelling, mechanical properties, and release profiles of Sr 2+ from the hydrogel scaffolds were comprehensively characterized. In vitro tests were conducted to assess cell viability and proliferation, as well as osteogenic and angiogenic gene expression, to investigate the osteogenic and pro-angiogenic potential of the composite hydrogel scaffolds. Furthermore, skull defect simulations were performed, and composite scaffolds with varying Sr 2+ ratios were implanted to evaluate their effectiveness in bone repair. This research establishes a foundation for advancing bone tissue engineering through composite scaffolds containing biological macromolecules and strontium, with alginate serving as a key element in enhancing performance and expanding clinical applicability. Competing Interests: Declaration of competing interest The authors declare that we have no conflict of interest related directly or indirectly to this paper. (Copyright © 2024. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: 3D-printing scaffold; Alginate; Bone defect repair; Strontium |
| المشرفين على المادة: | YZS2RPE8LE (Strontium) 0 (Alginates) 0 (Hydrogels) |
| تواريخ الأحداث: | Date Created: 20240610 Date Completed: 20240706 Latest Revision: 20240706 |
| رمز التحديث: | 20240706 |
| DOI: | 10.1016/j.ijbiomac.2024.133038 |
| PMID: | 38857724 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2024.133038 |