دورية أكاديمية
Neurotoxic and cardiotoxic effects of pyrogallol on catfish (Clarias gariepinus).
| العنوان: | Neurotoxic and cardiotoxic effects of pyrogallol on catfish (Clarias gariepinus). |
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| المؤلفون: | Hamed M; Department of Zoology, Faculty of Science, Al-Azhar University (Assiut branch), Assiut 71524, Egypt; Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA. Electronic address: mohamedhamedsayed239@gmail.com., Martyniuk CJ; Center for Environmental and Human Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA., Soliman HAM; Department of Zoology, Faculty of Science, Sohag University, Sohag 8562, Egypt., Osman AGM; Department of Zoology, Faculty of Science, Al-Azhar University (Assiut branch), Assiut 71524, Egypt., Said REM; Department of Zoology, Faculty of Science, Al-Azhar University (Assiut branch), Assiut 71524, Egypt. |
| المصدر: | Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2024 Aug; Vol. 109, pp. 104481. Date of Electronic Publication: 2024 Jun 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9612020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7077 (Electronic) Linking ISSN: 13826689 NLM ISO Abbreviation: Environ Toxicol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science B.V., c1996- |
| مواضيع طبية MeSH: | Catfishes* , Nitric Oxide*/metabolism , Nitric Oxide*/blood , Brain*/drug effects , Brain*/pathology , Pyrogallol*/toxicity , Water Pollutants, Chemical*/toxicity, Animals ; Acetylcholinesterase/metabolism ; Acetylcholinesterase/blood ; Heart/drug effects ; Myocardium/pathology ; Myocardium/metabolism ; Monoamine Oxidase/metabolism ; Cardiotoxicity |
| مستخلص: | Pyrogallol, a botanical hydrolysable tannin, has diverse medical and industrial applications. Its impact on aquatic ecosystems and fish health has been previously studied, revealing histopathological, immunological, biochemical, and haematological alterations in African catfish (Clarias gariepinus). In this study, the neurotoxic potential of pyrogallol was assessed through a 15-day exposure of catfish to concentrations of 1, 5, or 10 mg/L. Enzyme activities such as acetylcholinesterase (AchE), monoamine oxidase (MAO), aldehyde oxidase (AO), and nitric oxide (NO) were measured in serum and brain, along with histopathological examinations in the brain and heart. Pyrogallol exposure led to decreased AchE activity in the brain and serum, increased serum MAO activity, elevated AO in both brain and serum, and suppressed NO levels. Morphological abnormalities and dose-dependent pathological alterations were observed in the brain and heart, including neuropile deformities, shrunken Purkinje cells, cardiomyocyte degeneration, and increased collagen fibers. This suggests that pyrogallol induces adverse effects in fish. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Cardiotoxic; Catfish; Histopathology; Neurotoxicity; Pyrogallol |
| المشرفين على المادة: | 31C4KY9ESH (Nitric Oxide) 01Y4A2QXY0 (Pyrogallol) 0 (Water Pollutants, Chemical) EC 3.1.1.7 (Acetylcholinesterase) EC 1.4.3.4 (Monoamine Oxidase) |
| تواريخ الأحداث: | Date Created: 20240610 Date Completed: 20240720 Latest Revision: 20240720 |
| رمز التحديث: | 20240722 |
| DOI: | 10.1016/j.etap.2024.104481 |
| PMID: | 38857774 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1872-7077 |
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| DOI: | 10.1016/j.etap.2024.104481 |