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Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy.

التفاصيل البيبلوغرافية
العنوان: Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy.
المؤلفون: DeMoya CD; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Joenathan A; Division of Materials Science and Engineering, Boston University, Boston, MA, USA., Lawson TB; Department of Mechanical Engineering, Boston University, Boston, MA, USA., Felson DT; Section of Rheumatology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, USA., Schaer TP; PENN VET Institute for Medical Translation, University of Pennsylvania School of Veterinary Medicine New Bolton Center, Kennett Square, PA, USA., Bais M; Boston University, Henry M. Goldman School of Dental Medicine, Boston, MA, USA., Albro MB; Department of Mechanical Engineering, Boston University, Boston, MA, USA., Mäkelä J; Department of Technical Physics, University of Eastern Finland, Kuopio, Finland., Snyder BD; Department of Orthopaedic Surgery, Boston Children's Hospital Boston, Boston, MA, USA. Brian.Snyder@childrens.harvard.edu., Grinstaff MW; Department of Biomedical Engineering, Boston University, Boston, MA, USA. mgrin@bu.edu.; Division of Materials Science and Engineering, Boston University, Boston, MA, USA. mgrin@bu.edu.; Department of Chemistry, Boston University, Boston, MA, USA. mgrin@bu.edu.
المصدر: Nature reviews. Rheumatology [Nat Rev Rheumatol] 2024 Jul; Vol. 20 (7), pp. 432-451. Date of Electronic Publication: 2024 Jun 10.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101500080 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-4804 (Electronic) Linking ISSN: 17594790 NLM ISO Abbreviation: Nat Rev Rheumatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Group
مواضيع طبية MeSH: Viscosupplementation*/methods , Osteoarthritis*/drug therapy, Humans ; Hyaluronic Acid/therapeutic use ; Cartilage, Articular/drug effects ; Cartilage, Articular/metabolism ; Cartilage, Articular/pathology ; Viscosupplements/therapeutic use ; Viscosupplements/administration & dosage ; Synovial Fluid/metabolism ; Dietary Supplements
مستخلص: Joint kinematic instability, arising from congenital or acquired musculoskeletal pathoanatomy or from imbalances in anabolism and catabolism induced by pathophysiological factors, leads to deterioration of the composition, structure and function of cartilage and, ultimately, progression to osteoarthritis (OA). Alongside articular cartilage degeneration, synovial fluid lubricity decreases in OA owing to a reduction in the concentration and molecular weight of hyaluronic acid and surface-active mucinous glycoproteins that form a lubricating film over the articulating joint surfaces. Minimizing friction between articulating joint surfaces by lubrication is fundamental for decreasing hyaline cartilage wear and for maintaining the function of synovial joints. Augmentation with highly viscous supplements (that is, viscosupplementation) offers one approach to re-establishing the rheological and tribological properties of synovial fluid in OA. However, this approach has varied clinical outcomes owing to limited intra-articular residence time and ineffective mechanisms of chondroprotection. This Review discusses normal hyaline cartilage function and lubrication and examines the advantages and disadvantages of various strategies for restoring normal joint lubrication. These strategies include contemporary viscosupplements that contain antioxidants, anti-inflammatory drugs or platelet-rich plasma and new synthetic synovial fluid additives and cartilage matrix enhancers. Advanced biomimetic tribosupplements offer promise for mitigating cartilage wear, restoring joint function and, ultimately, improving patient care.
(© 2024. Springer Nature Limited.)
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المشرفين على المادة: 9004-61-9 (Hyaluronic Acid)
0 (Viscosupplements)
تواريخ الأحداث: Date Created: 20240610 Date Completed: 20240626 Latest Revision: 20240626
رمز التحديث: 20240627
DOI: 10.1038/s41584-024-01125-5
PMID: 38858605
قاعدة البيانات: MEDLINE
الوصف
تدمد:1759-4804
DOI:10.1038/s41584-024-01125-5