دورية أكاديمية
أعرض في EDS

First incidence of extrarenal wilms tumor within the spinal canal in the adult population: a novel case report and literature review.

التفاصيل البيبلوغرافية
العنوان: First incidence of extrarenal wilms tumor within the spinal canal in the adult population: a novel case report and literature review.
المؤلفون: Alijani B; Department of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.; Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran., Abbaspour E; Department of Radiology, Poursina Hospital, Guilan University of Medical Science, Rasht, Iran., Karimzadhagh S; Clinical Research Development Unit of Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran., Reihanian Z; Department of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.; Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran., Haghani Dogahe M; Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran., Jafari M; Student Research Committee, School of Medicine, Anzali International Campus, Guilan University of Medical Sciences, Rasht, Iran., Jafari S; Department of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.; Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran., Zaresharifi N; Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, 41937-13194, Iran. Nooshin_zaresharifi@yahoo.com.
المصدر: BMC urology [BMC Urol] 2024 Jun 10; Vol. 24 (1), pp. 119. Date of Electronic Publication: 2024 Jun 10.
نوع المنشور: Journal Article; Case Reports; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968571 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2490 (Electronic) Linking ISSN: 14712490 NLM ISO Abbreviation: BMC Urol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Wilms Tumor*/surgery , Spinal Canal*/pathology , Spinal Canal*/diagnostic imaging, Humans ; Female ; Young Adult ; Incidence ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Kidney Neoplasms/diagnostic imaging ; Spinal Neoplasms/surgery ; Spinal Neoplasms/diagnostic imaging
مستخلص: Background: Wilms tumor (WT), also known as nephroblastoma, is rare in adults, accounting for merely 3% of all nephroblastomas or 0.2 cases per million individuals. Extrarenal Wilms tumor (ERWT) emerges outside the renal boundaries and comprises 0.5 to 1% of all WT cases, with even rarer incidences in adults. Oncogenic mutations associated with ectopic nephrogenic rests (NR) may contribute to ERWT development. Diagnosis involves surgical resection and pathology examination. Due to scarce cases, adults often rely on pediatric guidelines. We thoroughly searched PubMed, Scopus, and Web of Science databases to establish our case's uniqueness. To the best of our knowledge, this is the first documented incidence of extrarenal Wilms tumor within the spinal canal in the adult population.
Case Presentation: A 22-year-old woman with a history of congenital lipo-myelomeningocele surgery as an infant presented with a 6-month history of back pain. This pain gradually resulted in limb weakness, paraparesis, and loss of bladder and bowel control. An MRI showed a 6 × 5 × 3 cm spinal canal mass at the L4-S1 level. Consequently, a laminectomy was performed at the L4-L5 level to remove the intramedullary tumor. Post-surgery histopathology and immunohistochemistry confirmed the tumor as ERWT with favorable histology without any teratomatous component.
Conclusion: This report underscores the rarity of extrarenal Wilms tumor (ERWT) in adults, challenging conventional assumptions about its typical age of occurrence. It emphasizes the importance of clinical awareness regarding such uncommon cases. Moreover, the co-occurrence of spinal ERWTs and a history of spinal anomalies warrants further investigation.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Extra-renal nephroblastoma; Extrarenal Wilms tumor; Nephroblastoma; Spinal dysraphism; Spinal tumors; Wilms tumor
تواريخ الأحداث: Date Created: 20240610 Date Completed: 20240611 Latest Revision: 20240613
رمز التحديث: 20240613
مُعرف محوري في PubMed: PMC11163749
DOI: 10.1186/s12894-024-01508-6
PMID: 38858693
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2490
DOI:10.1186/s12894-024-01508-6