دورية أكاديمية
أعرض في EDS

A thorough analysis of data on the correlation between COL9A1 polymorphisms and the susceptibility to congenital talipes equinovarus: a meta-analysis.

التفاصيل البيبلوغرافية
العنوان: A thorough analysis of data on the correlation between COL9A1 polymorphisms and the susceptibility to congenital talipes equinovarus: a meta-analysis.
المؤلفون: Golshan-Tafti M; Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran., Dastgheib SA; Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Alijanpour K; General Practitioner, Babol University of Medical Sciences, Babol, Iran. alijanpour.sur@gmail.com., Bahrami R; Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. r.bahrami.neo@gmail.com., Mazaheri M; Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Neamatzadeh H; Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
المصدر: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2024 Jun 10; Vol. 19 (1), pp. 345. Date of Electronic Publication: 2024 Jun 10.
نوع المنشور: Journal Article; Meta-Analysis
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-799X (Electronic) Linking ISSN: 1749799X NLM ISO Abbreviation: J Orthop Surg Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2006-
مواضيع طبية MeSH: Clubfoot*/genetics , Genetic Predisposition to Disease*/genetics , Collagen Type IX*/genetics, Humans ; Case-Control Studies ; Polymorphism, Single Nucleotide
مستخلص: Background: Congenital talipes equinovarus (CTEV) is a prevalent pediatric deformity with a multifactorial etiology. The objective of this meta-analysis was to explore the association between genetic variations in COL9A1 and the susceptibility to CTEV.
Methods: A comprehensive analysis of pertinent literature released before November 15, 2023, in electronic bibliographic databases was carried out. The importance of the connection was clarified through odds ratios (ORs) with 95% confidence intervals (CIs), utilizing random or fixed-effects models depending on study heterogeneity. Statistical analysis was executed using Comprehensive Meta-Analysis software (Version 4.0).
Results: A total of eight case-control studies involving 833 CTEV patients and 1280 healthy individuals were included in the analysis. Among these, four studies investigated the rs1135056 variant, encompassing 432 CTEV cases and 603 controls; two studies examined the rs35470562 variant, with 189 CTEV cases and 378 controls; and two studies explored the rs592121 variant, including 212 CTEV cases and 299 controls. The results revealed a significant association between the rs1135056 and rs35470562 polymorphisms in the COL9A1 gene, suggesting an increased risk of CTEV in the overall population. Conversely, no such association was found for the rs592121 variant.
Conclusion: Our findings reveal a substantial association between the genetic variants COL9A1 rs1135056 and rs35470562 and susceptibility to CTEV. Conversely, the variant rs592121 did not exhibit any corresponding link. However, the limitations imposed by the small study population have compromised the statistical reliability and generalizability of the results.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: COL9A1; CTEV; Congenital clubfoot; Foot deformities; Polymorphism; Talipes equinovarus
المشرفين على المادة: 0 (Collagen Type IX)
0 (COL9A1 protein, human)
تواريخ الأحداث: Date Created: 20240610 Date Completed: 20240611 Latest Revision: 20240613
رمز التحديث: 20240613
مُعرف محوري في PubMed: PMC11163731
DOI: 10.1186/s13018-024-04834-5
PMID: 38858754
قاعدة البيانات: MEDLINE
الوصف
تدمد:1749-799X
DOI:10.1186/s13018-024-04834-5