دورية أكاديمية
Successful treatment with reduced oral steroid dosage in an 81-year-old woman with statin-induced anti-HMGCR immune-mediated necrotizing myopathy.
العنوان: | Successful treatment with reduced oral steroid dosage in an 81-year-old woman with statin-induced anti-HMGCR immune-mediated necrotizing myopathy. |
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المؤلفون: | Kondo S; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Kurihara M; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Higashihara M; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Hara M; Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Nishina Y; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Iwakiri R; Department of Geriatrics, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Murayama S; Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Saito Y; Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Iwata A; Department of Neurology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan. |
المصدر: | Geriatrics & gerontology international [Geriatr Gerontol Int] 2024 Jul; Vol. 24 (7), pp. 739-742. Date of Electronic Publication: 2024 Jun 11. |
نوع المنشور: | Case Reports; Journal Article; Letter |
اللغة: | English |
بيانات الدورية: | Publisher: Japan Geriatrics Society Country of Publication: Japan NLM ID: 101135738 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1447-0594 (Electronic) Linking ISSN: 14470594 NLM ISO Abbreviation: Geriatr Gerontol Int Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Tokyo, Japan] : Carlton, Vic., Australia : Japan Geriatrics Society ; Blackwell Science, c2001- |
مواضيع طبية MeSH: | Hydroxymethylglutaryl-CoA Reductase Inhibitors*/adverse effects , Hydroxymethylglutaryl-CoA Reductase Inhibitors*/administration & dosage , Muscular Diseases*/drug therapy , Muscular Diseases*/chemically induced , Muscular Diseases*/immunology , Muscular Diseases*/diagnosis, Humans ; Female ; Aged, 80 and over ; Necrosis ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Administration, Oral ; Hydroxymethylglutaryl CoA Reductases/immunology |
مستخلص: | An 81-year-old woman presented with statin-induced anti-HMGCR immune-mediated necrotizing myopathy. Treatment was successful without complications with a reduced oral steroid dosage from the current consensus for all ages and backgrounds. This case suggests the importance of early diagnosis and the possibility of steroid dosage adjustment considering the patient's age, disease severity, and comorbidities. (© 2024 Japan Geriatrics Society.) |
References: | Mammen AL, Chung T, Christopher‐Stine L et al. Autoantibodies against 3‐hydroxy‐3‐methylglutaryl‐coenzyme a reductase in patients with statin‐associated autoimmune myopathy. Arthritis Rheum 2011; 63: 713–721. https://doi.org/10.1002/art.30156. Allenbach Y, Mammen AL, Benveniste O, Stenzel W, Immune‐Mediated Necrotizing Myopathies Working G. 224th ENMC international workshop:: Clinico‐sero‐pathological classification of immune‐mediated necrotizing myopathies Zandvoort, The Netherlands, 14–16 October 2016. Neuromuscul Disord 2018; 28: 87–99. https://doi.org/10.1016/j.nmd.2017.09.016. Kajinami K, Tsukamoto K, Koba S et al. Statin Intolerance Clinical Guide 2018. J Atheroscler Thromb 2020; 27: 375–396. https://doi.org/10.5551/jat.50948. Khoo T, Chinoy H. Anti‐HMGCR immune‐mediated necrotising myopathy: addressing the remaining issues. Autoimmun Rev 2023; 22: 103468. https://doi.org/10.1016/j.autrev.2023.103468. Allenbach Y, Benveniste O, Stenzel W, Boyer O. Immune‐mediated necrotizing myopathy: clinical features and pathogenesis. Nat Rev Rheumatol 2020; 16: 689–701. https://doi.org/10.1038/s41584-020-00515-9. Watanabe Y, Uruha A, Suzuki S et al. Clinical features and prognosis in anti‐SRP and anti‐HMGCR necrotising myopathy. J Neurol Neurosurg Psychiatry 2016; 87: 1038–1044. https://doi.org/10.1136/jnnp-2016-313166. Koshi EJ, Young K, Mostales JC, Vo KB, Burgess LP. Complications of corticosteroid therapy: a comprehensive literature review. J Pharm Technol 2022; 38: 360–367. https://doi.org/10.1177/87551225221116266. Mills E, Devendra S. Steroid‐induced hyperglycaemia in primary care. London J Prim Care 2015; 7: 103–106. https://doi.org/10.1080/17571472.2015.1082344. Fardet L, Petersen I, Nazareth I. Suicidal behavior and severe neuropsychiatric disorders following glucocorticoid therapy in primary care. Am J Psychiatry 2012; 169: 491–497. https://doi.org/10.1176/appi.ajp.2011.11071009. Meyer A, Troyanov Y, Drouin J et al. Statin‐induced anti‐HMGCR myopathy: successful therapeutic strategies for corticosteroid‐free remission in 55 patients. Arthritis Res Ther 2020; 22: 5. https://doi.org/10.1186/s13075-019-2093-6. Tiniakou E, Pinal‐Fernandez I, Lloyd TE et al. More severe disease and slower recovery in younger patients with anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme a reductase‐associated autoimmune myopathy. Rheumatology (Oxford) 2017; 56: 787–794. https://doi.org/10.1093/rheumatology/kew470. |
معلومات مُعتمدة: | JP20FC1049 Ministry of Health, Labor, and Welfare; JP22wm0425019 Japan Agency for Medical Research and Development; JP22H04923 Japan Society for the Promotion of Science; JP23K14789 Japan Society for the Promotion of Science |
فهرسة مساهمة: | Keywords: HMG‐CoA reductase; aged 80 and over; multimorbidity; myopathies; statin |
المشرفين على المادة: | 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) 0 (Glucocorticoids) EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases) EC 1.1.1.- (HMGCR protein, human) |
تواريخ الأحداث: | Date Created: 20240611 Date Completed: 20240701 Latest Revision: 20240722 |
رمز التحديث: | 20240722 |
DOI: | 10.1111/ggi.14922 |
PMID: | 38860537 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1447-0594 |
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DOI: | 10.1111/ggi.14922 |