دورية أكاديمية
Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew.
| العنوان: | Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew. |
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| المؤلفون: | Jones CW; Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Overbey EG; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.; Center for STEM, University of Austin, Austin, TX, USA., Lacombe J; Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.; Department of Basic Medical Sciences; College of Medicine Phoenix, University of Arizona, Phoenix, AZ, USA., Ecker AJ; Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Meydan C; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Ryon K; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Tierney B; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Damle N; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., MacKay M; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Afshin EE; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Foox J; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Park J; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Nelson T; Department of Microbiology & Immunology, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Suhail M; TrialX Inc., New York, NY, USA., Byhaqui SG; TrialX Inc., New York, NY, USA., Aslam B; TrialX Inc., New York, NY, USA., Tali UA; TrialX Inc., New York, NY, USA., Nisa L; TrialX Inc., New York, NY, USA., Menon P; TrialX Inc., New York, NY, USA., Patel CO; TrialX Inc., New York, NY, USA., Khan SA; TrialX Inc., New York, NY, USA., Ebert DJ; KBR, Science & Space, Houston, TX, USA., Everson A; KBR, Science & Space, Houston, TX, USA., Schubert MC; Department of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ali NN; Department of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sarma MS; Department of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kim J; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Houerbi N; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Grigorev K; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Garcia Medina S; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Summers AJ; Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA., Gu J; Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.; Department of Basic Medical Sciences; College of Medicine Phoenix, University of Arizona, Phoenix, AZ, USA., Altin JA; The Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA., Fattahi A; Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA., Hirzallah MI; Departments of Neurology and Neurosurgery, Baylor College of Medicine, Houston, TX, USA.; Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA., Wu JH; Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.; Translational Research Institute for Space Health, Houston, TX, USA., Stahn AC; Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Beheshti A; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Blue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Klotz R; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Ortiz V; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Yu M; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Patras L; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania., Matei I; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Lyden D; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Melnick A; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA., Banerjee N; SpaceX, Hawthorne, CA, USA., Mullane S; SpaceX, Hawthorne, CA, USA., Kleinman A; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Loesche M; SpaceX, Hawthorne, CA, USA., Menon AS; University of Texas, Department of Emergency Medicine, Houston, TX, USA., Donoviel DB; Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.; Translational Research Institute for Space Health, Houston, TX, USA., Urquieta E; Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.; Translational Research Institute for Space Health, Houston, TX, USA., Mateus J; SpaceX, Hawthorne, CA, USA., Sargsyan AE; KBR, Science & Space, Houston, TX, USA., Shelhamer M; Department of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zenhausern F; Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.; Department of Basic Medical Sciences; College of Medicine Phoenix, University of Arizona, Phoenix, AZ, USA.; The Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.; Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA., Bershad EM; Departments of Neurology and Neurosurgery, Baylor College of Medicine, Houston, TX, USA.; Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA., Basner M; Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. basner@pennmediicne.upenn.edu., Mason CE; Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu. |
| المصدر: | Nature [Nature] 2024 Jun 11. Date of Electronic Publication: 2024 Jun 11. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basingstoke : Nature Publishing Group Original Publication: London, Macmillan Journals ltd. |
| مستخلص: | Human spaceflight has historically been managed by government agencies, such as the NASA Twins Study 1 , but new commercial spaceflight opportunities have opened spaceflight to a broader population. In 2021, the SpaceX Inspiration4 mission launched the first-ever all civilian crew to low Earth orbit, which included the youngest American astronaut (age 29), novel in-flight experimental technologies (handheld ultrasound imaging, smartwatch wearables, and immune profiling), ocular alignment measurements, and new protocols for in-depth, multi-omic molecular and cellular profiling. Here we report the primary findings from the 3-day spaceflight mission, which induced a broad range of physiological and stress responses, neurovestibular changes indexed by ocular misalignment, and altered neurocognitive functioning, some of which match long-term spaceflight 2 , but almost all of which did not differ from baseline (pre-flight) after return to Earth. Overall, these preliminary civilian spaceflight data suggest that short-duration missions do not pose a significant health risk, and moreover present a rich opportunity to measure the earliest phases of adaptation to spaceflight in the human body at anatomical, cellular, physiologic, and cognitive levels. Finally, these methods and results lay the foundation for an open, rapidly expanding biomedical database for astronauts 3 , which can inform countermeasure development for both private and government-sponsored space missions. (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.) |
| تواريخ الأحداث: | Date Created: 20240611 Latest Revision: 20240611 |
| رمز التحديث: | 20240612 |
| DOI: | 10.1038/s41586-024-07648-x |
| PMID: | 38862026 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1476-4687 |
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| DOI: | 10.1038/s41586-024-07648-x |