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Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).

التفاصيل البيبلوغرافية
العنوان: Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).
المؤلفون: Overbey EG; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; BioAstra, Inc, New York, NY, USA.; Center for STEM, University of Austin, Austin, TX, 78701, USA., Ryon K; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA., Kim J; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Tierney BT; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Klotz R; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Ortiz V; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Mullane S; Space Exploration Technologies Corporation, Hawthorne, CA, USA., Schmidt JC; Sovaris Aerospace, Boulder, Colorado, USA.; Advanced Pattern Analysis & Human Performance Group, Boulder, Colorado, USA., MacKay M; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA., Damle N; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA., Najjar D; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA., Matei I; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA., Patras L; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania., Garcia Medina JS; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA., Kleinman AS; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA., Wain Hirschberg J; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA., Proszynski J; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA., Narayanan SA; Florida State University, College of Education, Health, and Human Sciences, Department of Health, Nutrition, and Food Sciences, Tallahassee, FL, USA., Schmidt CM; Sovaris Aerospace, Boulder, Colorado, USA.; Advanced Pattern Analysis & Human Performance Group, Boulder, Colorado, USA.; Department of Systems Engineering, Colorado State University, Fort Collins, Colorado, USA., Afshin EE; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA., Innes L; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA., Saldarriaga MM; Hematology and Oncology Division, Weill Cornell Medicine, New York, NY, USA., Schmidt MA; Sovaris Aerospace, Boulder, Colorado, USA.; Advanced Pattern Analysis & Human Performance Group, Boulder, Colorado, USA., Granstein RD; Department of Dermatology, Weill Cornell Medicine, New York, NY, USA., Shirah B; Department of Neuroscience, King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia., Yu M; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Lyden D; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA., Mateus J; Space Exploration Technologies Corporation, Hawthorne, CA, USA., Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA. chm2042@med.cornell.edu.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.; BioAstra, Inc, New York, NY, USA. chm2042@med.cornell.edu.; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10021, USA. chm2042@med.cornell.edu.; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, 10021, USA. chm2042@med.cornell.edu.
المصدر: Nature communications [Nat Commun] 2024 Jun 11; Vol. 15 (1), pp. 4964. Date of Electronic Publication: 2024 Jun 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Space Flight* , Biological Specimen Banks* , Specimen Handling*/methods, Humans ; Astronauts
مستخلص: The SpaceX Inspiration4 mission provided a unique opportunity to study the impact of spaceflight on the human body. Biospecimen samples were collected from four crew members longitudinally before (Launch: L-92, L-44, L-3 days), during (Flight Day: FD1, FD2, FD3), and after (Return: R + 1, R + 45, R + 82, R + 194 days) spaceflight, spanning a total of 289 days across 2021-2022. The collection process included venous whole blood, capillary dried blood spot cards, saliva, urine, stool, body swabs, capsule swabs, SpaceX Dragon capsule HEPA filter, and skin biopsies. Venous whole blood was further processed to obtain aliquots of serum, plasma, extracellular vesicles and particles, and peripheral blood mononuclear cells. In total, 2,911 sample aliquots were shipped to our central lab at Weill Cornell Medicine for downstream assays and biobanking. This paper provides an overview of the extensive biospecimen collection and highlights their processing procedures and long-term biobanking techniques, facilitating future molecular tests and evaluations.As such, this study details a robust framework for obtaining and preserving high-quality human, microbial, and environmental samples for aerospace medicine in the Space Omics and Medical Atlas (SOMA) initiative, which can aid future human spaceflight and space biology experiments.
(© 2024. The Author(s).)
التعليقات: Update of: bioRxiv. 2023 May 02:2023.05.02.539108. doi: 10.1101/2023.05.02.539108. (PMID: 37205403)
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معلومات مُعتمدة: R01 ES032638 United States ES NIEHS NIH HHS; R01 MH117406 United States MH NIMH NIH HHS
تواريخ الأحداث: Date Created: 20240611 Date Completed: 20240611 Latest Revision: 20240624
رمز التحديث: 20240624
مُعرف محوري في PubMed: PMC11166662
DOI: 10.1038/s41467-024-48806-z
PMID: 38862509
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-024-48806-z