دورية أكاديمية
أعرض في EDS

Factors associated with phenotypes of dyspnea in post-COVID-19 condition: a cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Factors associated with phenotypes of dyspnea in post-COVID-19 condition: a cross-sectional study.
المؤلفون: Smith MP; Division of Pulmonary Medicine, Department of Medicine, University of Alberta and Alberta Health Services, 3-111C Clinical Sciences Building, 11302 83 Ave NW, Edmonton, T6G 2G3, AB, Canada.; Alberta Respiratory Centre, University of Alberta, Edmonton, AB, Canada., Sharpe H; Division of Pulmonary Medicine, Department of Medicine, University of Alberta and Alberta Health Services, 3-111C Clinical Sciences Building, 11302 83 Ave NW, Edmonton, T6G 2G3, AB, Canada., Damant RW; Division of Pulmonary Medicine, Department of Medicine, University of Alberta and Alberta Health Services, 3-111C Clinical Sciences Building, 11302 83 Ave NW, Edmonton, T6G 2G3, AB, Canada.; Alberta Respiratory Centre, University of Alberta, Edmonton, AB, Canada., Ferrara G; Division of Pulmonary Medicine, Department of Medicine, University of Alberta and Alberta Health Services, 3-111C Clinical Sciences Building, 11302 83 Ave NW, Edmonton, T6G 2G3, AB, Canada.; Alberta Respiratory Centre, University of Alberta, Edmonton, AB, Canada., Lim RK; Division of Respiratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Stickland MK; Division of Pulmonary Medicine, Department of Medicine, University of Alberta and Alberta Health Services, 3-111C Clinical Sciences Building, 11302 83 Ave NW, Edmonton, T6G 2G3, AB, Canada.; Alberta Respiratory Centre, University of Alberta, Edmonton, AB, Canada., Lam GY; Division of Pulmonary Medicine, Department of Medicine, University of Alberta and Alberta Health Services, 3-111C Clinical Sciences Building, 11302 83 Ave NW, Edmonton, T6G 2G3, AB, Canada. glam@ualberta.ca.; Alberta Respiratory Centre, University of Alberta, Edmonton, AB, Canada. glam@ualberta.ca.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada. glam@ualberta.ca.
المصدر: Scientific reports [Sci Rep] 2024 Jun 11; Vol. 14 (1), pp. 13387. Date of Electronic Publication: 2024 Jun 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Dyspnea*/etiology , Dyspnea*/physiopathology , COVID-19*/complications , COVID-19*/virology , Phenotype* , Fatigue*/etiology, Humans ; Female ; Male ; Middle Aged ; Cross-Sectional Studies ; Adult ; SARS-CoV-2/isolation & purification ; Post-Acute COVID-19 Syndrome ; Quality of Life ; Aged ; Body Mass Index ; Alberta/epidemiology ; Hospitalization
مستخلص: Post-COVID-19 condition (PCC) is defined as the persistence of symptoms, like fatigue and dyspnea, at least 3 months post-COVID infection. As dyspnea is a common symptom, we attempted to further clinically phenotype those with PCC-associated dyspnea. 1642 adults (average age of 49.6y with 63% female-predominance and BMI of 31.2 kg/m 2 ) with physician confirmed diagnosis of PCC from June 2020-April 2023 in Alberta, Canada were included. Those with dyspnea were more likely to be female (56.5%, p = 0.005) and have higher BMI (31.3 kg/m 2 vs. 29.5 kg/m 2 ; p = 0.0008), history of asthma (21.1% vs. 12.3%; p < 0.001), more persistent PCC symptoms (p = 0.0001), more functional limitations, as well as lower quality of life (p < 0.0001). Multivariable-adjusted logistic regression analysis demonstrated dyspnea was independently associated with fatigue (OR = 4.20; CI = 2.71,6.59) and inversely associated with hospitalization for COVID-19 (OR = 0.53; CI = 0.32,0.91), age (OR = 0.98 per one year of age; CI = 0.96,0.99) and 6-min-walk-distance per 10 m difference (OR = 0.98, CI = 0.96,1.0). Fatigue was a predictor of dyspnea, and was associated with milder infection, higher BMI, and reduced 6-min-walk-distance despite normal pulmonary function. Reduced TLC or DLCO was associated with more severe infection and reduced 6-min-walk-distance. Thus, we speculate there are at least two dyspnea-associated phenotypes: phenotype with pronounced fatigue (normal PFT) and phenotype with pronounced pulmonary abnormalities (abnormal PFT). Improved understanding of the dyspnea-associated phenotypes may allow for better targeted rehabilitation.
(© 2024. The Author(s).)
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تواريخ الأحداث: Date Created: 20240611 Date Completed: 20240611 Latest Revision: 20240614
رمز التحديث: 20240614
مُعرف محوري في PubMed: PMC11167032
DOI: 10.1038/s41598-024-64370-4
PMID: 38862585
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-64370-4