دورية أكاديمية
Correlation of CT features of lung adenocarcinoma with sex and age.
| العنوان: | Correlation of CT features of lung adenocarcinoma with sex and age. |
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| المؤلفون: | Yang Y; Department of Radiology, Huadong Hospital, Fudan University, Shanghai, 200040, China., Gao Y; Department of Radiology, Huadong Hospital, Fudan University, Shanghai, 200040, China., Lu F; Department of Radiology, Huadong Hospital, Fudan University, Shanghai, 200040, China., Wang E; Department of Radiology, Huadong Hospital, Fudan University, Shanghai, 200040, China., Liu H; Department of Radiology, Huadong Hospital, Fudan University, Shanghai, 200040, China. liuhaiquan8811@163.com. |
| المصدر: | Scientific reports [Sci Rep] 2024 Jun 11; Vol. 14 (1), pp. 13414. Date of Electronic Publication: 2024 Jun 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Adenocarcinoma of Lung*/diagnostic imaging , Adenocarcinoma of Lung*/pathology , Tomography, X-Ray Computed* , Lung Neoplasms*/diagnostic imaging , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics, Humans ; Male ; Female ; Middle Aged ; Aged ; Age Factors ; Retrospective Studies ; Sex Factors ; Adult ; Aged, 80 and over ; ErbB Receptors/genetics |
| مستخلص: | This study aimed to retrospectively examine the computed tomography (CT) features of lung adenocarcinoma across different demographic groups. Preoperative chest CT findings from 1266 surgically resected lung adenocarcinoma cases were retrospectively analyzed. Lung adenocarcinomas were categorized based on CT characteristics into pure ground glass (pGGO), nodule-containing ground glass opacity (mGGO), and pure solid without containing ground glass opacity (pSD). These categories were correlated with sex, age, EGFR status, and five histopathological subtypes. The diameters of pGGO, mGGO, and pSD significantly increased across all patient groups (P < 0.05). Males exhibited a significantly higher proportion of pSD than females (P = 0.002). The mean diameters of pGGO and pSD were significantly larger in males than in females (P = 0.0017 and P = 0.043, respectively). The frequency of pGGO was higher in the younger age group (≤ 60 years) compared to the older group (> 60 years) for both males (P = 0.002) and females (P = 0.027). The frequency of pSD was higher in the older age group for both sexes. A linear correlation between age and diameter was observed in the entire cohort as well as in the male and female groups (P < 0.0001 for all groups). EGFR mutations were less frequent in pSD compared to pGGO (P = 0.0002) and mGGO (P < 0.0001). The frequency of lesions containing micropapillary components increased from pGGO to mGGO and pSD (P < 0.0001 for all). The frequency of lesions containing solid components also increased from pGGO to mGGO and pSD (P = 0.045, P < 0.0001, and P < 0.0001, respectively). The CT features of lung adenocarcinoma exhibit differences across genders and age groups. Male gender and older age are risk factors for lung adenocarcinoma growth. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: CT feature; Lung adenocarcinoma; Sex; pSD |
| المشرفين على المادة: | EC 2.7.10.1 (ErbB Receptors) |
| تواريخ الأحداث: | Date Created: 20240611 Date Completed: 20240611 Latest Revision: 20240614 |
| رمز التحديث: | 20240614 |
| مُعرف محوري في PubMed: | PMC11167049 |
| DOI: | 10.1038/s41598-024-64335-7 |
| PMID: | 38862598 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-024-64335-7 |