دورية أكاديمية
أعرض في EDS

Shifts in structural connectome organization in the limbic and sensory systems of patients with episodic migraine.

التفاصيل البيبلوغرافية
العنوان: Shifts in structural connectome organization in the limbic and sensory systems of patients with episodic migraine.
المؤلفون: Noh E; College of Medicine, Inha University, Incheon, Republic of Korea., Namgung JY; Department of Data Science, Inha University, Incheon, Republic of Korea., Park Y; Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Republic of Korea., Jang Y; Department of Statistics and Data Science, Inha University, Incheon, Republic of Korea., Lee MJ; Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. mijilee.md@snu.ac.kr., Park BY; Department of Data Science, Inha University, Incheon, Republic of Korea. boyong.park@inha.ac.kr.; Department of Statistics and Data Science, Inha University, Incheon, Republic of Korea. boyong.park@inha.ac.kr.; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea. boyong.park@inha.ac.kr.
المصدر: The journal of headache and pain [J Headache Pain] 2024 Jun 11; Vol. 25 (1), pp. 99. Date of Electronic Publication: 2024 Jun 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100940562 Publication Model: Electronic Cited Medium: Internet ISSN: 1129-2377 (Electronic) Linking ISSN: 11292369 NLM ISO Abbreviation: J Headache Pain Subsets: MEDLINE
أسماء مطبوعة: Publication: [2018]- : [London, United Kingdom] : BioMed Central
Original Publication: Milano : Springer Verlag Italia, c2000-c2017.
مواضيع طبية MeSH: Migraine Disorders*/diagnostic imaging , Migraine Disorders*/pathology , Connectome*/methods, Humans ; Female ; Adult ; Male ; Limbic System/diagnostic imaging ; Limbic System/pathology ; Diffusion Tensor Imaging/methods ; Young Adult
مستخلص: Migraine is a complex neurological condition characterized by recurrent headaches, which is often accompanied by various neurological symptoms. Magnetic resonance imaging (MRI) is a powerful tool for investigating whole-brain connectivity patterns; however, systematic assessment of structural connectome organization has rarely been performed. In the present study, we aimed to examine the changes in structural connectivity in patients with episodic migraines using diffusion MRI. First, we computed structural connectivity using diffusion MRI tractography, after which we applied dimensionality reduction techniques to the structural connectivity and generated three low-dimensional eigenvectors. We subsequently calculated the manifold eccentricity, defined as the Euclidean distance between each data point and the center of the data in the manifold space. We then compared the manifold eccentricity between patients with migraines and healthy controls, revealing significant between-group differences in the orbitofrontal cortex, temporal pole, and sensory/motor regions. Between-group differences in subcortico-cortical connectivity further revealed significant changes in the amygdala, accumbens, and caudate nuclei. Finally, supervised machine learning effectively classified patients with migraines and healthy controls using cortical and subcortical structural connectivity features, highlighting the importance of the orbitofrontal and sensory cortices, in addition to the caudate, in distinguishing between the groups. Our findings confirmed that episodic migraine is related to the structural connectome changes in the limbic and sensory systems, suggesting its potential utility as a diagnostic marker for migraine.
(© 2024. The Author(s).)
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معلومات مُعتمدة: NRF2020R1A2B5B01001826 National Research Foundation of Korea; NRF2022R1A5A7033499 National Research Foundation of Korea; Project number: RS-2023-00229484 Korea Medical Device Development Fund; No. 2022-0-00448, Deep Total Recall: Continuous Learning for Human-Like Recall of Artificial Neural Networks Institute for Information and Communications Technology Promotion; IBS-R015-D1 Institute for Basic Science
فهرسة مساهمة: Keywords: Episodic migraine; Limbic system; Manifold eccentricity; Structural connectivity; Tractography
تواريخ الأحداث: Date Created: 20240611 Date Completed: 20240611 Latest Revision: 20240613
رمز التحديث: 20240613
مُعرف محوري في PubMed: PMC11165833
DOI: 10.1186/s10194-024-01806-2
PMID: 38862883
قاعدة البيانات: MEDLINE
الوصف
تدمد:1129-2377
DOI:10.1186/s10194-024-01806-2