دورية أكاديمية
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Relationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet intervention.

التفاصيل البيبلوغرافية
العنوان: Relationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet intervention.
المؤلفون: Soldevila-Domenech N; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain.; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, 08003, Spain., Fagundo B; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain.; Department of Physiotherapy, Fundació Universitària del Bages (FUB), Manresa, 08042, Spain., Cuenca-Royo A; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain., Forcano L; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain.; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain., Gomis-González M; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain., Boronat A; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain., Pastor A; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain.; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain., Castañer O; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain.; Endocrinology Service, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain., Zomeño MD; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain.; School of Health Sciences, Blanquerna-Ramon Llull University, Barcelona, 08022, Spain., Goday A; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain.; Endocrinology Service, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain., Dierssen M; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, 08003, Spain.; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, 08003, Spain.; CIBER de Enfermedades Raras (CIBERER), Barcelona, Spain., Baghizadeh Hosseini K; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, 08003, Spain.; Cardiovascular risk, Nutrition and Aging, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, 08036, Spain., Ros E; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, 46010, Spain., Corella D; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain., Martínez-González MÁ; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Navarra's Health Research Institute (IdiSNA), Pamplona, Spain.; Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Unitat de Nutrició Humana, Reus, Spain., Salas-Salvadó J; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain., Fernández-Aranda F; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Clinical Psychology Unit, University Hospital of Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08908, Spain.; Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.; Psychoneurobiology of Eating and Addictive Behaviors Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08908, Spain., Fitó M; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Research Institute (HMRI), Barcelona, 08003, Spain., de la Torre R; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, 08003, Spain. rtorre2@researchmar.net.; CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28029, Spain. rtorre2@researchmar.net.; Neurosciences Research Program, Hospital del Mar Research Institute (HMRI), Dr Aiguader 88, Barcelona, 08003, Spain. rtorre2@researchmar.net.
المصدر: Nutrition journal [Nutr J] 2024 Jun 12; Vol. 23 (1), pp. 61. Date of Electronic Publication: 2024 Jun 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101152213 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2891 (Electronic) Linking ISSN: 14752891 NLM ISO Abbreviation: Nutr J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2002-
مواضيع طبية MeSH: Cognition*/physiology , Diet, Mediterranean*/statistics & numerical data , Endocannabinoids*/blood , Genotype* , Metabolic Syndrome*/genetics, Aged ; Female ; Humans ; Male ; Middle Aged ; Amides ; Apolipoproteins E/genetics ; Arachidonic Acids/blood ; Biomarkers/blood ; Ethanolamines/blood ; Glycerides/blood ; Oleic Acids/blood ; Palmitic Acids/blood ; Polyunsaturated Alkamides/blood ; Prospective Studies ; Sex Factors
مستخلص: Background: The Mediterranean diet (MedDiet) has demonstrated efficacy in preventing age-related cognitive decline and modulating plasma concentrations of endocannabinoids (eCBs) and N-acylethanolamines (NAEs, or eCB-like compounds), which are lipid mediators involved in multiple neurological disorders and metabolic processes. Hypothesizing that eCBs and NAEs will be biomarkers of a MedDiet intervention and will be related to the cognitive response, we investigated this relationship according to sex and apolipoprotein E (APOE) genotype, which may affect eCBs and cognitive performance.
Methods: This was a prospective cohort study of 102 participants (53.9% women, 18.8% APOE-ɛ4 carriers, aged 65.6 ± 4.5 years) from the PREDIMED-Plus-Cognition substudy, who were recruited at the Hospital del Mar Research Institute (Barcelona). All of them presented metabolic syndrome plus overweight/obesity (inclusion criteria of the PREDIMED-Plus) and normal cognitive performance at baseline (inclusion criteria of this substudy). A comprehensive battery of neuropsychological tests was administered at baseline and after 1 and 3 years. Plasma concentrations of eCBs and NAEs, including 2-arachidonoylglycerol (2-AG), anandamide (AEA), oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and N-docosahexaenoylethanolamine (DHEA), were also monitored. Baseline cognition, cognitive changes, and the association between eCBs/NAEs and cognition were evaluated according to gender (crude models), sex (adjusted models), and APOE genotype.
Results: At baseline, men had better executive function and global cognition than women (the effect size of gender differences was - 0.49, p = 0.015; and - 0.42, p = 0.036); however, these differences became nonsignificant in models of sex differences. After 3 years of MedDiet intervention, participants exhibited modest improvements in memory and global cognition. However, greater memory changes were observed in men than in women (Cohen's d of 0.40 vs. 0.25; p = 0.017). In men and APOE-ε4 carriers, 2-AG concentrations were inversely associated with baseline cognition and cognitive changes, while in women, cognitive changes were positively linked to changes in DHEA and the DHEA/AEA ratio. In men, changes in the OEA/AEA and OEA/PEA ratios were positively associated with cognitive changes.
Conclusions: The MedDiet improved participants' cognitive performance but the effect size was small and negatively influenced by female sex. Changes in 2-AG, DHEA, the OEA/AEA, the OEA/PEA and the DHEA/AEA ratios were associated with cognitive changes in a sex- and APOE-dependent fashion. These results support the modulation of the endocannabinoid system as a potential therapeutic approach to prevent cognitive decline in at-risk populations.
Trial Registration: ISRCTN89898870.
(© 2024. The Author(s).)
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معلومات مُعتمدة: FI_B2021/00104 Agència de Gestió d'Ajuts Universitaris i de Recerca; PROMETEO/2017/017; Grant FEA/SEA 2017 for Primary Care Research Generalitat Valenciana; PI13/00233, PI13/00728, PI13/01123, PI13/00462, PI16/00533, PI16/00366, PI16/01094, PI16/00501, PI17/01167, PI19/00017, PI19/00781, PI19/01032, PI19/00576 Instituto de Salud Carlos III; PI13/00233, PI13/00728, PI13/01123, PI13/00462, PI16/00533, PI16/00366, PI16/01094, PI16/00501, PI17/01167, PI19/00017, PI19/00781, PI19/01032, PI19/00576 Instituto de Salud Carlos III; PI13/00233, PI13/00728, PI13/01123, PI13/00462, PI16/00533, PI16/00366, PI16/01094, PI16/00501, PI17/01167, PI19/00017, PI19/00781, PI19/01032, PI19/00576 Instituto de Salud Carlos III; Advanced Research Grant 2014-2019; agreement #340918 HORIZON EUROPE European Research Council; SLT006/17/00246, SLT002/16/00045 and SLT006/17/00077 Departament de Salut, Generalitat de Catalunya; SLT006/17/00246, SLT002/16/00045 and SLT006/17/00077 Departament de Salut, Generalitat de Catalunya; SLT006/17/00246, SLT002/16/00045 and SLT006/17/00077 Departament de Salut, Generalitat de Catalunya; 2013ACUP00194 'la Caixa' Foundation; Eat2beNICE/ H2020-SFS-2016-2; Ref 728018; and PRIME/ H2020-SC1-BHC-2018-2020; Ref: 847879 H2020 European Institute of Innovation and Technology; Eat2beNICE/ H2020-SFS-2016-2; Ref 728018; and PRIME/ H2020-SC1-BHC-2018-2020; Ref: 847879 H2020 European Institute of Innovation and Technology; Eat2beNICE/ H2020-SFS-2016-2; Ref 728018; and PRIME/ H2020-SC1-BHC-2018-2020; Ref: 847879 H2020 European Institute of Innovation and Technology; Eat2beNICE/ H2020-SFS-2016-2; Ref 728018; and PRIME/ H2020-SC1-BHC-2018-2020; Ref: 847879 H2020 European Institute of Innovation and Technology; 2017 SGR 138 Generalitat de Catalunya
فهرسة مساهمة: Keywords: 2-AG; Cognition; Endocannabinoids; Mediterranean diet; Metabolic syndrome; Sex differences
المشرفين على المادة: 0 (Amides)
UR5G69TJKH (anandamide)
0 (Apolipoproteins E)
0 (Arachidonic Acids)
0 (Biomarkers)
0 (Endocannabinoids)
0 (Ethanolamines)
0 (Glycerides)
8D239QDW64 (glyceryl 2-arachidonate)
0 (N-acylethanolamines)
0 (Oleic Acids)
1HI5J9N8E6 (oleoylethanolamide)
6R8T1UDM3V (palmidrol)
0 (Palmitic Acids)
0 (Polyunsaturated Alkamides)
0 (ApoE protein, human)
تواريخ الأحداث: Date Created: 20240611 Date Completed: 20240612 Latest Revision: 20240625
رمز التحديث: 20240625
مُعرف محوري في PubMed: PMC11167771
DOI: 10.1186/s12937-024-00966-w
PMID: 38862960
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2891
DOI:10.1186/s12937-024-00966-w