دورية أكاديمية
أعرض في EDS

Variations in colostrum metabolite profiles in association with sow parity.

التفاصيل البيبلوغرافية
العنوان: Variations in colostrum metabolite profiles in association with sow parity.
المؤلفون: Vötterl JC; Centre for Veterinary Systems Transformation and Sustainability, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine, 1210 Vienna, Austria.; Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Schwartz-Zimmermann HE; Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.; Institute of Bioanalytics and Agro-Metabolomics, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), 3430 Tulln, Austria., Lerch F; Centre for Veterinary Systems Transformation and Sustainability, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine, 1210 Vienna, Austria.; Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, >University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Yosi F; Centre for Veterinary Systems Transformation and Sustainability, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine, 1210 Vienna, Austria.; Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.; Department of Animal Science, Faculty of Agriculture, University of Sriwijaya, 30662 Palembang, Indonesia., Sharma S; Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.; Centre for Animal Nutrition and Welfare, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Aigensberger M; Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.; Institute of Bioanalytics and Agro-Metabolomics, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), 3430 Tulln, Austria., Rennhofer PM; Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.; Institute of Bioanalytics and Agro-Metabolomics, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), 3430 Tulln, Austria., Berthiller F; Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.; Institute of Bioanalytics and Agro-Metabolomics, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), 3430 Tulln, Austria., Metzler-Zebeli BU; Centre for Veterinary Systems Transformation and Sustainability, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine, 1210 Vienna, Austria.; Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
المصدر: Translational animal science [Transl Anim Sci] 2024 May 03; Vol. 8, pp. txae062. Date of Electronic Publication: 2024 May 03 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101738705 Publication Model: eCollection Cited Medium: Internet ISSN: 2573-2102 (Electronic) Linking ISSN: 25732102 NLM ISO Abbreviation: Transl Anim Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Oxford : Oxford University Press
Original Publication: [Champaign, IL] : American Society of Animal Science, [2017]-
مستخلص: Information about the full spectrum of metabolites present in porcine colostrum and factors that influence metabolite abundances is still incomplete. Parity number appears to modulate the concentration of single metabolites in colostrum. This study aimed to 1) characterize the metabolome composition and 2) assess the effect of parity on metabolite profiles in porcine colostrum. Sows ( n  = 20) were divided into three parity groups: A) sows in parity 1 and 2 ( n  = 8), B) sows in parity 3 and 4 ( n  = 6), and C) sows in parity 5 and 6 ( n  = 6). Colostrum was collected within 12 h after parturition. A total of 125 metabolites were identified using targeted reversed-phase high-performance liquid chromatography-tandem mass spectrometry and anion-exchange chromatography-high resolution mass spectrometry. Gas chromatography additionally identified 19 fatty acids (FAs). Across parities, colostrum was rich in creatine and creatinine, 1,3-dioleyl-2-palmitatoylglycerol, 1,3-dipalmitoyl-2-oleoylglycerol, and sialyllactose. Alterations in colostrum concentrations were found for eight metabolites among parity groups ( P  < 0.05) but the effects were not linear. For instance, colostrum from parity group C comprised 75.4% more valine but 15.7%, 34.1%, and 47.9% less citric, pyruvic, and pyroglutamic acid, respectively, compared to group A ( P  < 0.05). By contrast, colostrum from parity group B contained 39.5% more spermidine than from group A ( P  < 0.05). Of the FAs, C18:1, C16:0, and C18:2 n6 were the main FAs across parities. Parity affected four FAs (C18:3n3, C14:1, C17:0ai, and C17:1), including 43.1% less α-linolenic acid (C18:3n3) in colostrum from parity group C compared to groups A and B ( P  < 0.05). Signature feature ranking identified 1-stearoyl-2-hydroxy- sn -glycero-3-phosphatidylcholine and the secondary bile acid hyodeoxycholic acid as the most discriminative metabolites, showing a higher variable importance in the projection score in colostrum from parity group A than from groups B and C. Overall, results provided a comprehensive overview about the metabolome composition of sow colostrum. The consequences of the changes in colostrum metabolites with increasing parity for the nutrient supply of the piglets should be investigated in the future. The knowledge gained in this study could be used to optimize feeding strategies for sows.
Competing Interests: The authors declare no conflict of interest other than the fact that BIOMIN Holding, which is part of dsm-firmenich provided partial funding for this research but had no influence on data analysis, data interpretation, and preparation of the manuscript.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society of Animal Science.)
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فهرسة مساهمة: Keywords: colostrum; fatty acids; metabolome; parity; sows
تواريخ الأحداث: Date Created: 20240612 Latest Revision: 20240613
رمز التحديث: 20240613
مُعرف محوري في PubMed: PMC11165641
DOI: 10.1093/tas/txae062
PMID: 38863596
قاعدة البيانات: MEDLINE
الوصف
تدمد:2573-2102
DOI:10.1093/tas/txae062