دورية أكاديمية
Plasma exchange in thrombotic thrombocytopenic purpuras.
| عنوان ترانسليتريتد: | Plasma exchange in thrombotic thrombocytopenic purpuras. |
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| المؤلفون: | Jabr D; Clinical Hematology Department, Aziza Othmana Hospital, Faculty of Medicine of Tunis, University of Tunis el Manar, Tunis, Tunisia., Hsasna R; Clinical Hematology Department, Aziza Othmana Hospital, Faculty of Medicine of Tunis, University of Tunis el Manar, Tunis, Tunisia., Kefi S; Clinical Hematology Department, Aziza Othmana Hospital, Faculty of Medicine of Tunis, University of Tunis el Manar, Tunis, Tunisia., Kharrat R; Clinical Hematology Department, Aziza Othmana Hospital, Faculty of Medicine of Tunis, University of Tunis el Manar, Tunis, Tunisia., Ben Neji H; Clinical Hematology Department, Aziza Othmana Hospital, Faculty of Medicine of Tunis, University of Tunis el Manar, Tunis, Tunisia., Ben Lakhal R; Clinical Hematology Department, Aziza Othmana Hospital, Faculty of Medicine of Tunis, University of Tunis el Manar, Tunis, Tunisia. |
| المصدر: | La Tunisie medicale [Tunis Med] 2024 Jun 05; Vol. 102 (6), pp. 343-347. Date of Electronic Publication: 2024 Jun 05. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | French |
| بيانات الدورية: | Publisher: Societe Tunisienne Des Sciences Medicales Country of Publication: Tunisia NLM ID: 0413766 Publication Model: Electronic Cited Medium: Internet ISSN: 2724-7031 (Electronic) Linking ISSN: 00414131 NLM ISO Abbreviation: Tunis Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tunis : Societe Tunisienne Des Sciences Medicales |
| مواضيع طبية MeSH: | Purpura, Thrombotic Thrombocytopenic*/therapy , Purpura, Thrombotic Thrombocytopenic*/diagnosis , Plasma Exchange*/methods, Humans ; Retrospective Studies ; Female ; Male ; Middle Aged ; Adult ; Young Adult ; Treatment Outcome ; Aged ; Recurrence ; Plasmapheresis/methods ; Adolescent ; Rituximab/therapeutic use ; Rituximab/administration & dosage |
| مستخلص: | Introduction: Thrombotic thrombocytopenic purpura (TTP) is a rare but potentially fatal hematological disorder that requires urgent treatment. Once the diagnosis has been made, plasma exchange (PE) must be started immediately and until a response is obtained. Aim: Evaluate PE in terms of responses and complications in the treatment of TTP. Methods: This was a monocentric, descriptive, retrospective study including patients in whom TTP was diagnosed and treated with plasmapheresis in the clinical hematology department at Aziza Othmana Hospital, between January 2010 and December 2020. Results: Our study included 26 patients. PE was initiated within a median of 1 day. The rhythm of exchanges was daily in 22 patients. Twenty PE-related complications were noted, hypocalcemia being the most frequent (30%). CR was achieved in 15 patients after PE alone. Nine patients were refractory, and six received 2nd-line treatment, with CR achieved in five patients. Relapse was noted in six patients (40%). They were treated by PE and only one patient received rituximab. Four patients had a response. The overall response rate was 69% and overall mortality was 30%. OS at 2 years was 68,3% and RFS was 84,4%. Factors associated with the achievement of CR were the fall in LDH at D5 of treatment (p=0,027,OR=0,59 ;IC 95%[0,32-1,08]) and the daily rhythm of PE (p=0,005, OR=0,35; IC 95%[0,14-0,91]). Conclusion: Our results were comparable to those of the literature, but the rate of refractory disease was higher. Rituximab may enhance our results. |
| فهرسة مساهمة: | Keywords: Plasmapheresis; Survival; Thrombotic microangiopathies; Thrombotic thrombocytopenic purpura |
| المشرفين على المادة: | 4F4X42SYQ6 (Rituximab) |
| تواريخ الأحداث: | Date Created: 20240612 Date Completed: 20240612 Latest Revision: 20240612 |
| رمز التحديث: | 20240612 |
| DOI: | 10.62438/tunismed.v102i6.4614 |
| PMID: | 38864197 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2724-7031 |
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| DOI: | 10.62438/tunismed.v102i6.4614 |