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Hydrogen sulfide maintains mitochondrial homeostasis and regulates ganoderic acids biosynthesis by SQR under heat stress in Ganoderma lucidum.

التفاصيل البيبلوغرافية
العنوان: Hydrogen sulfide maintains mitochondrial homeostasis and regulates ganoderic acids biosynthesis by SQR under heat stress in Ganoderma lucidum.
المؤلفون: Shangguan J; Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, PR China., Wu T; Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, PR China., Tian L; Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, PR China., Liu Y; Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, PR China., Zhu L; Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, PR China., Liu R; Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, PR China., Zhu J; Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, PR China., Shi L; Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, PR China., Zhao M; Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, PR China. Electronic address: mwzhao@njau.edu.cn., Ren A; Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, PR China. Electronic address: angren@njau.edu.cn.
المصدر: Redox biology [Redox Biol] 2024 Aug; Vol. 74, pp. 103227. Date of Electronic Publication: 2024 Jun 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam]: Elsevier, B.V., [2013]-
مواضيع طبية MeSH: Hydrogen Sulfide*/metabolism , Reishi*/metabolism , Reishi*/genetics , Triterpenes*/metabolism , Mitochondria*/metabolism , Homeostasis* , Heat-Shock Response* , Membrane Potential, Mitochondrial*/drug effects, Quinone Reductases/metabolism ; Quinone Reductases/genetics ; DNA, Mitochondrial/genetics ; Electron Transport Complex III/metabolism ; Electron Transport Complex III/genetics
مستخلص: Hydrogen sulfide (H 2 S) has recently been recognized as an important gaseous transmitter with multiple physiological effects in various species. Previous studies have shown that H 2 S alleviated heat-induced ganoderic acids (GAs) biosynthesis, an important quality index of Ganoderma lucidum. However, a comprehensive understanding of the physiological effects and molecular mechanisms of H 2 S in G. lucidum remains unexplored. In this study, we found that heat treatment reduced the mitochondrial membrane potential (MMP) and mitochondrial DNA copy number (mtDNAcn) in G. lucidum. Increasing the intracellular H 2 S concentration through pharmacological and genetic means increased the MMP level, mtDNAcn, oxygen consumption rate level and ATP content under heat treatment, suggesting a role for H 2 S in mitigating heat-caused mitochondrial damage in G. lucidum. Further results indicated that H 2 S activates sulfide-quinone oxidoreductase (SQR) and complex III (Com III), thereby maintaining mitochondrial homeostasis under heat stress in G. lucidum. Moreover, SQR also mediated the negative regulation of H 2 S to GAs biosynthesis under heat stress. Furthermore, SQR might be persulfidated under heat stress in G. lucidum. Thus, our study reveals a novel physiological function and molecular mechanism of H 2 S signalling under heat stress in G. lucidum with broad implications for research on the environmental response of microorganisms.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
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فهرسة مساهمة: Keywords: Ganoderic acids; Ganoderma lucidum; Hydrogen sulfide; Mitochondrial homeostasis; Sulfide-quinone oxidoreductase
المشرفين على المادة: YY9FVM7NSN (Hydrogen Sulfide)
0 (ganoderic acid)
0 (Triterpenes)
EC 1.8.5.- (sulfide quinone reductase)
EC 1.6.99.- (Quinone Reductases)
0 (DNA, Mitochondrial)
EC 7.1.1.8 (Electron Transport Complex III)
تواريخ الأحداث: Date Created: 20240612 Date Completed: 20240617 Latest Revision: 20240703
رمز التحديث: 20240703
مُعرف محوري في PubMed: PMC11215418
DOI: 10.1016/j.redox.2024.103227
PMID: 38865903
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-2317
DOI:10.1016/j.redox.2024.103227