دورية أكاديمية
Role of CETP, PCSK-9, and CYP7-alpha in cholesterol metabolism: Potential targets for natural products in managing hypercholesterolemia.
| العنوان: | Role of CETP, PCSK-9, and CYP7-alpha in cholesterol metabolism: Potential targets for natural products in managing hypercholesterolemia. |
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| المؤلفون: | Aguchem RN; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Enugu State 410001, Nigeria., Okagu IU; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Enugu State 410001, Nigeria., Okorigwe EM; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Enugu State 410001, Nigeria; Department of Chemistry and Biochemistry, College of Sciences, University of Notre Dame, 46556 Notre Dame, IN, United States., Uzoechina JO; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Enugu State 410001, Nigeria; Department of Biochemistry and Molecular Biology, Institute of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, PR China., Nnemolisa SC; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Enugu State 410001, Nigeria., Ezeorba TPC; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Enugu State 410001, Nigeria; Department of Genetics and Biotechnology, Faculty of Biological Sciences, University of Nigeria, Enugu State 410001, Nigeria; Department of Environmental Health and Risk Management, College of Life and Environmental Sciences, University of Birmingham, Edgbaston B15 2TT, United Kingdom. Electronic address: timothy.ezeorba@unn.edu.ng. |
| المصدر: | Life sciences [Life Sci] 2024 Aug 15; Vol. 351, pp. 122823. Date of Electronic Publication: 2024 Jun 10. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Cholesterol Ester Transfer Proteins*/metabolism , Cholesterol Ester Transfer Proteins*/antagonists & inhibitors , Proprotein Convertase 9*/metabolism , Biological Products*/therapeutic use , Biological Products*/pharmacology , Hypercholesterolemia*/drug therapy , Hypercholesterolemia*/metabolism , Cholesterol*/metabolism , Cholesterol 7-alpha-Hydroxylase*/metabolism, Humans ; Animals |
| مستخلص: | Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide, primarily affecting the heart and blood vessels, with atherosclerosis being a major contributing factor to their onset. Epidemiological and clinical studies have linked high levels of low-density lipoprotein (LDL) emanating from distorted cholesterol homeostasis as its major predisposing factor. Cholesterol homeostasis, which involves maintaining the balance in body cholesterol level, is mediated by several proteins or receptors, transcription factors, and even genes, regulating cholesterol influx (through dietary intake or de novo synthesis) and efflux (by their conversion to bile acids). Previous knowledge about CVDs management has evolved around modulating these receptors' activities through synthetic small molecules/antibodies, with limited interest in natural products. The central roles of the cholesteryl ester transfer protein (CETP), proprotein convertase subtilisin/kexin type 9 (PCSK9), and cytochrome P450 family 7 subfamily A member 1 (CYP7A1), among other proteins or receptors, have fostered growing scientific interests in understanding more on their regulatory activities and potential as drug targets. We present up-to-date knowledge on the contributions of CETP, PCSK9, and CYP7A1 toward CVDs, highlighting the clinical successes and failures of small molecules/antibodies to modulate their activities. In recommendation for a new direction to improve cardiovascular health, we have presented recent findings on natural products (including functional food, plant extracts, phytochemicals, bioactive peptides, and therapeutic carbohydrates) that also modulate the activities of CETP, PCSK-9, and CYP7A1, and emphasized the need for more research efforts redirected toward unraveling more on natural products potentials even at clinical trial level for CVD management. Competing Interests: Declaration of competing interest The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Blood, inflammation; Cardiovascular; Peptide; Phytochemicals; Polysaccharides |
| المشرفين على المادة: | 0 (Cholesterol Ester Transfer Proteins) EC 3.4.21.- (Proprotein Convertase 9) 0 (Biological Products) EC 3.4.21.- (PCSK9 protein, human) 97C5T2UQ7J (Cholesterol) EC 1.14.14.23 (Cholesterol 7-alpha-Hydroxylase) 0 (CETP protein, human) EC 1.14.14.23 (CYP7A1 protein, human) |
| تواريخ الأحداث: | Date Created: 20240612 Date Completed: 20240701 Latest Revision: 20240708 |
| رمز التحديث: | 20240709 |
| DOI: | 10.1016/j.lfs.2024.122823 |
| PMID: | 38866219 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0631 |
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| DOI: | 10.1016/j.lfs.2024.122823 |