دورية أكاديمية
Sex Differences in Dopamine Release in Nucleus Accumbens and Dorsal Striatum Determined by Chronic Fast-Scan Cyclic Voltammetry: Effects of Social Housing and Repeated Stimulation.
| العنوان: | Sex Differences in Dopamine Release in Nucleus Accumbens and Dorsal Striatum Determined by Chronic Fast-Scan Cyclic Voltammetry: Effects of Social Housing and Repeated Stimulation. |
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| المؤلفون: | Gonzalez IL; Departments of Psychology, University of Michigan., Turner CA; Departments of Psychology, University of Michigan., Patel PR; Biomedical Engineering, University of Michigan., Leonardo NB; Departments of Psychology, University of Michigan.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109., Luma BD; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109., Richie JM; Biomedical Engineering, University of Michigan., Cai D; Department of Cell & Developmental Biology, University of Michigan., Chestek CA; Biomedical Engineering, University of Michigan.; Robotics Graduate Program, University of Michigan.; Neuroscience Graduate Program, University of Michigan.; Department of Electrical Engineering and Computer Science, University of Michigan., Becker JB; Departments of Psychology, University of Michigan jbbecker@med.umich.edu.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109. |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Jul 17; Vol. 44 (29). Date of Electronic Publication: 2024 Jul 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Nucleus Accumbens*/metabolism , Dopamine*/metabolism , Sex Characteristics* , Corpus Striatum*/metabolism , Electric Stimulation*/methods, Animals ; Male ; Female ; Rats ; Rats, Sprague-Dawley ; Housing, Animal ; Ovariectomy ; Methamphetamine/pharmacology |
| مستخلص: | We investigated sex differences in dopamine (DA) release in the nucleus accumbens (NAc) and dorsolateral striatum (DLS) using a chronic 16-channel carbon fiber electrode and fast-scan cyclic voltammetry (FSCV). Electrical stimulation-induced (ES; 60 Hz) DA release was recorded in the NAc of single- or pair-housed male and female rats. When core (NAcC) and shell (NAcS) were recorded simultaneously, there was greater ES DA release in NAcC of pair-housed females compared with single females and males. Housing did not affect ES NAc DA release in males. In contrast, there was significantly more ES DA release from the DLS of female rats than male rats. This was true prior to and after treatment with methamphetamine. Furthermore, in castrated (CAST) males and ovariectomized (OVX) females, there were no sex differences in ES DA release from the DLS, demonstrating the hormone dependence of this sex difference. However, in the DLS of both intact and gonadectomized rats, DA reuptake was slower in females than that in males. Finally, DA release following ES of the medial forebrain bundle at 60 Hz was studied over 4 weeks. ES DA release increased over time for both CAST males and OVX females, demonstrating sensitization. Using this novel 16-channel chronic FSCV electrode, we found sex differences in the effects of social housing in the NAcS, sex differences in DA release from intact rats in DLS, and sex differences in DA reuptake in DLS of intake and gonadectomized rats, and we report sensitization of ES-induced DA release in DLS in vivo. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 Gonzalez et al.) |
| التعليقات: | Update of: bioRxiv. 2024 Mar 01:2023.08.14.553278. doi: 10.1101/2023.08.14.553278. (PMID: 37645814) |
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| معلومات مُعتمدة: | T32 DA007281 United States DA NIDA NIH HHS; UF1 NS107659 United States NS NINDS NIH HHS |
| فهرسة مساهمة: | Keywords: dopamine; fast-scan cyclic voltammetry; nucleus accumbens; sex difference; striatum |
| المشرفين على المادة: | VTD58H1Z2X (Dopamine) 44RAL3456C (Methamphetamine) |
| تواريخ الأحداث: | Date Created: 20240612 Date Completed: 20240717 Latest Revision: 20240816 |
| رمز التحديث: | 20240816 |
| مُعرف محوري في PubMed: | PMC11255425 |
| DOI: | 10.1523/JNEUROSCI.1527-23.2024 |
| PMID: | 38866486 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1529-2401 |
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| DOI: | 10.1523/JNEUROSCI.1527-23.2024 |