دورية أكاديمية
أعرض في EDS

Assessing the risks for stillbirth in São Paulo, Brazil: protocol for a multidisciplinary case-control study - FetRisks.

التفاصيل البيبلوغرافية
العنوان: Assessing the risks for stillbirth in São Paulo, Brazil: protocol for a multidisciplinary case-control study - FetRisks.
المؤلفون: Buralli RJ; Departamento de Medicina Preventiva, Universidade de Sao Paulo Faculdade de Medicina, Sao Paulo, Brazil rafael.buralli@gmail.com., da Silva ZP; Departamento de Epidemiologia, Universidade de Sao Paulo Faculdade de Saude Publica, São Paulo, Brazil., Alencar GP; Departamento de Epidemiologia, Universidade de Sao Paulo Faculdade de Saude Publica, São Paulo, Brazil., Figueiredo GM; Universidade de São Paulo Instituto de Medicina Tropical de São Paulo, Sao Paulo, Brazil.; Departamento de Medicina Preventiva, Universidade de São Paulo Faculdade de Medicina, São Paulo, Brazil., Hoshida MS; Laboratorio de Investigaçao Medica em Fisiologia Obstetrica (LIM 57), Universidade de São Paulo Hospital das Clínicas, São Paulo, Brazil., Luna EJA; Departamento de Medicina Preventiva, Universidade de São Paulo Faculdade de Medicina, São Paulo, Brazil.; Universidade de São Paulo Instituto de Medicina Tropical de São Paulo, São Paulo, Brazil., Pastro LDM; Departamento de Medicina Preventiva, Universidade de São Paulo Faculdade de Medicina, São Paulo, Brazil., Santos OAD; Departamento de Medicina Preventiva, Universidade de São Paulo Faculdade de Medicina, São Paulo, Brazil., Marques LJP; Departamento de Epidemiologia, Universidade de São Paulo Faculdade de Saude Pública, São Paulo, Brazil., Zerbinati RM; Laboratorio de Virologia (LIM 52), Universidade de São Paulo Instituto de Medicina Tropical de São Paulo, São Paulo, Brazil., Galisteo Junior AJ; Laboratorio de Investigaçao Medica em Protozoologia, Bacteriologia e Resistencia Antimicrobiana (LIM 49), Universidade de Sao Paulo Hospital das Clinicas, São Paulo, Brazil., Andrade Junior H; Universidade de São Paulo Instituto de Medicina Tropical de São Paulo, São Paulo, Brazil.; Laboratorio de Anatomia Patologica, Universidade de Sao Paulo Hospital das Clinicas, São Paulo, Brazil., Machado CM; Universidade de São Paulo Instituto de Medicina Tropical de São Paulo, São Paulo, Brazil.; Laboratorio de Virologia (LIM 52), Universidade de São Paulo Instituto de Medicina Tropical de São Paulo, São Paulo, Brazil., Meireles LR; Universidade de São Paulo Instituto de Medicina Tropical de São Paulo, São Paulo, Brazil., Schultz R; Laboratorio de Anatomia Patologica, Universidade de Sao Paulo Hospital das Clinicas, São Paulo, Brazil., Rodrigues LC; London School of Hygiene & Tropical Medicine, London, UK., Francisco RPV; Laboratorio de Investigaçao Medica em Fisiologia Obstetrica (LIM 57), Universidade de São Paulo Hospital das Clínicas, São Paulo, Brazil.; Departamento de Obstetricia e Ginecologia, Universidade de Sao Paulo Faculdade de Medicina, São Paulo, Brazil., Novaes HMD; Departamento de Medicina Preventiva, Universidade de São Paulo Faculdade de Medicina, São Paulo, Brazil., Almeida MF; Departamento de Epidemiologia, Universidade de Sao Paulo Faculdade de Saude Publica, São Paulo, Brazil., Gouveia N; Departamento de Medicina Preventiva, Universidade de Sao Paulo Faculdade de Medicina, Sao Paulo, Brazil.
المصدر: BMJ open [BMJ Open] 2024 Jun 12; Vol. 14 (6), pp. e079261. Date of Electronic Publication: 2024 Jun 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
مواضيع طبية MeSH: Stillbirth*/epidemiology, Humans ; Brazil/epidemiology ; Case-Control Studies ; Female ; Pregnancy ; Risk Factors ; Prenatal Care ; Research Design ; Risk Assessment ; Placenta/pathology
مستخلص: Stillbirth is a fundamental component of childhood mortality, but its causes are still insufficiently understood. This study aims to explore stillbirth risk factors by using a multidisciplinary approach to stimulate public policies and protocols to prevent stillbirth, improve maternal care and support bereaved families. METHODS AND ANALYSIS: In this case-control study with stillbirths and live births in 14 public hospitals in São Paulo, mothers are interviewed at hospitals after delivery, and hospital records and prenatal care registries are reviewed. Maternal and umbilical cord blood samples and placentas are collected to analyse angiogenesis and infection biomarkers, and the placenta's anatomopathological exam. Air pollutant exposure is estimated through the participant's residence and work addresses. Traditional and non-invasive autopsies by image-guided histopathology are conducted in a subset of stillbirths. Subsample mothers of cases are interviewed at home 2 months after delivery on how they were dealing with grief. Information contained in the official prenatal care registries of cases and controls is being compiled. Hospital managers are interviewed about the care offered to stillbirth mothers. Data analysis will identify the main risk factors for stillbirth, investigate their interrelations, and evaluate health services care and support for bereaved families. We hope this project will contribute to the understanding of stillbirth's risk factors and related health services in Brazil, providing new knowledge about this central public health problem, contributing to the improvement of public policies and prenatal and puerperal care, helping to prevent stillbirths and improve the healthcare and support for bereaved families. ETHICS AND DISSEMINATION: This study protocol was approved by the Ethics Committee of the Municipal Health Secretary (process no 16509319.0.3012.5551) and of the Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (process no 16509319.0.0000.0068). Results will be communicated to the study participants, policy-makers and the scientific community.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: case-control studies; fetal medicine; latin america; prenatal diagnosis; public health
تواريخ الأحداث: Date Created: 20240612 Date Completed: 20240612 Latest Revision: 20240616
رمز التحديث: 20240616
مُعرف محوري في PubMed: PMC11177680
DOI: 10.1136/bmjopen-2023-079261
PMID: 38866578
قاعدة البيانات: MEDLINE
الوصف
تدمد:2044-6055
DOI:10.1136/bmjopen-2023-079261