دورية أكاديمية
Mapping macrostructural and microstructural brain alterations in patients with neuronal intranuclear inclusion disease.
| العنوان: | Mapping macrostructural and microstructural brain alterations in patients with neuronal intranuclear inclusion disease. |
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| المؤلفون: | Lv S; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.; Tiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing, China., Tai H; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China., Sun J; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.; Tiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing, China., Zhuo Z; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.; Tiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing, China., Duan Y; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.; Tiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing, China., Liu S; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China., Wang A; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China., Zhang Z; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. ttyy0142011@126.com.; China National Clinical Research Center for Neurological Diseases, Beijing, China. ttyy0142011@126.com., Liu Y; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. yaouliu80@163.com.; Tiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing, China. yaouliu80@163.com. |
| المصدر: | Neuroradiology [Neuroradiology] 2024 Aug; Vol. 66 (8), pp. 1373-1382. Date of Electronic Publication: 2024 Jun 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 1302751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1920 (Electronic) Linking ISSN: 00283940 NLM ISO Abbreviation: Neuroradiology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Neurodegenerative Diseases*/diagnostic imaging , Neurodegenerative Diseases*/pathology , Intranuclear Inclusion Bodies*/pathology , Diffusion Magnetic Resonance Imaging*/methods, Humans ; Male ; Female ; Middle Aged ; Case-Control Studies ; Aged ; Adult ; Anisotropy ; Brain/diagnostic imaging ; Brain/pathology |
| مستخلص: | Background and Purpose: Neuronal intranuclear inclusion disease (NIID) is a rare complex neurodegenerative disorder presents with various radiological features. The study aimed to investigate the structural abnormalities in NIID using multi-shell diffusion MR. Materials and Methods: Twenty-eight patients with adult-onset NIID and 32 healthy controls were included. Volumetric and diffusion MRI measures, including volume, fractional anisotropy (FA), mean diffusivity (MD), intracellular volume fraction (ICVF), orientation dispersion index (ODI), and isotropic volume fraction (ISOVF) of six brain structures, including cortex, subcortical GM, cerebral WM, cerebellar GM and WM, and brainstem, were obtained and compared between NIID and healthy controls. Associations between MRI measures and clinical variables were investigated. Results: Brain lesions of NIID included corticomedullary junction lesions on DWI, confluent leukoencephalopathy, lesions on callosum, cerebellar middle peduncle, cerebellar paravermal area and brainstem, and brain atrophy. Compared to healthy controls, NIID showed extensive volume loss of all the six brain regions (all p < 0.001); lower FA in cerebral WM (p < 0.001); higher MD in all WM regions; lower ODI in cortex (p < 0.001); higher ODI in subcortical GM (p < 0.001) and brainstem (p = 0.016); lower ICVF in brainstem (p = 0.001), and cerebral WM (p < 0.001); higher ISOVF in all the brain regions (p < 0.001). Higher MD of cerebellar WM was associated with worse cognitive level as evaluated by MoCA scores (p = 0.011). Conclusions: NIID patients demonstrated widespread brain atrophy but heterogeneous diffusion alterations. Cerebellar WM integrity impairment was correlated with the cognitive decline. The findings of the current study offer a sophisticated picture of brain structural alterations in NIID. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| معلومات مُعتمدة: | 82330057 the National Science Foundation of China; CX23YZ01 Capital Medical Science Innovation Center Scientific Research Pioneering Projec; DFL2022050 Beijing Municipal Hospital Administration Dengfeng; 20230484428 the Cross-Research Project of Beijing Science and Technology Star Program; YJXJ-JZ-2021-0014 Beijing E-Town Cooperation & Development Foundation; PYZ23120 Scientific Research Cultivation Fund of Capital Medical University |
| فهرسة مساهمة: | Keywords: Cognitive decline; Multi-shell diffiusion MR; Neurite orientation dispersion and density imaging; Neuronal intranuclear inclusion disease |
| SCR Disease Name: | Neuronal intranuclear inclusion disease |
| تواريخ الأحداث: | Date Created: 20240612 Date Completed: 20240713 Latest Revision: 20240719 |
| رمز التحديث: | 20240720 |
| DOI: | 10.1007/s00234-024-03406-y |
| PMID: | 38866958 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-1920 |
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| DOI: | 10.1007/s00234-024-03406-y |