دورية أكاديمية

Review of the In Vitro Microbiological Activity of Mecillinam Against Common Uropathogens in Uncomplicated Urinary Tract Infection: Focus on Resistant Pathogens.

التفاصيل البيبلوغرافية
العنوان: Review of the In Vitro Microbiological Activity of Mecillinam Against Common Uropathogens in Uncomplicated Urinary Tract Infection: Focus on Resistant Pathogens.
المؤلفون: Lodise TP; Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA., Kaye KS; Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA., Santerre Henriksen A; Maxel Consulting ApS, Jyllinge, Denmark., Kahlmeter G; Department of Clinical Microbiology, Central Hospital, Växjö, Sweden.
المصدر: Open forum infectious diseases [Open Forum Infect Dis] 2024 May 24; Vol. 11 (6), pp. ofae296. Date of Electronic Publication: 2024 May 24 (Print Publication: 2024).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]-
مستخلص: Antimicrobial resistance in uropathogens commonly causing urinary tract infections (UTIs) is a growing problem internationally. Pivmecillinam, the oral prodrug of mecillinam, has been used for over 40 years, primarily in Northern Europe and Canada. It is recommended in several countries as a first-line agent for the treatment of uncomplicated UTIs (uUTIs) and is now approved in the United States. We performed a structured literature search to review the available evidence on susceptibility of common uUTI-causing uropathogens to mecillinam. Among 38 studies included in this literature review, susceptibility rates for Escherichia coli to mecillinam-including resistant phenotypes such as extended-spectrum β-lactamase-producing E. coli -exceed 90% in most studies. High rates of susceptibility were also reported among many other uropathogens including Klebsiella spp., Enterobacter spp., and Citrobacter spp. In the current prescribing climate within the United States, pivmecillinam represents a viable first-line treatment option for patients with uUTI.
Competing Interests: Potential conflicts of interest. T.L.: consultant and advisory board member for UTILITY therapeutics. K.S.K.: consultant for AbbVie, CARB-X, GSK, Merck, and Shionogi. A.S.H.: consultant for UTILITY therapeutics. G.K.: no conflicts of interest.
(© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
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فهرسة مساهمة: Keywords: ESBL; Enterobacterales; mecillinam; resistance; uncomplicated urinary tract infection
تواريخ الأحداث: Date Created: 20240613 Latest Revision: 20240628
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC11167674
DOI: 10.1093/ofid/ofae296
PMID: 38868308
قاعدة البيانات: MEDLINE
الوصف
تدمد:2328-8957
DOI:10.1093/ofid/ofae296