دورية أكاديمية
Association of ACE2 and TMPRSS2 genes variants with disease severity and most important biomarkers in COVID-19 patients in Bosnia and Herzegovina.
| العنوان: | Association of ACE2 and TMPRSS2 genes variants with disease severity and most important biomarkers in COVID-19 patients in Bosnia and Herzegovina. |
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| المؤلفون: | Meseldžić N, Prnjavorac B, Dujić T, Malenica M, Glamočlija U, Prnjavorac L, Bedak O, Imamović Kadrić S, Marjanović D, Bego T; Tamer Bego, Department of Pharmaceutical Biochemistry and Laboratory Diagnostics, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina, tamer.bego@ffsa.unsa.ba. |
| المصدر: | Croatian medical journal [Croat Med J] 2024 Jun 13; Vol. 65 (3), pp. 220-231. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medicinska Naklada Country of Publication: Croatia NLM ID: 9424324 Publication Model: Print Cited Medium: Internet ISSN: 1332-8166 (Electronic) Linking ISSN: 03539504 NLM ISO Abbreviation: Croat Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2001- : Zagreb : Medicinska Naklada Original Publication: Zagreb : University of Zagreb Medical School, [1992- |
| مواضيع طبية MeSH: | Serine Endopeptidases*/genetics , COVID-19*/genetics , COVID-19*/epidemiology , Angiotensin-Converting Enzyme 2*/genetics , Polymorphism, Single Nucleotide* , Severity of Illness Index* , Biomarkers*/blood, Humans ; Male ; Female ; Bosnia and Herzegovina ; Middle Aged ; SARS-CoV-2/genetics ; Adult ; Aged ; Genotype |
| مستخلص: | Aim: To assess the association of single nucleotide polymorphisms (SNPs) in the ACE2 and TMPRSS2 genes with COVID-19 severity and key biomarkers. Methods: The study involved 750 COVID-19 patients from Bosnia and Herzegovina, divided into three groups: mild, moderate, and severe cases. Genetic variations within the ACE2 (rs2285666) and TMPRSS2 (rs2070788) genes were examined with real-time polymerase chain reaction. Biochemical markers were determined with standard procedures. Results: There was a significant difference in the rs2070788 genotype distribution between patients with mild and moderate symptoms, but not between other groups. For the rs2285666 polymorphism, no significant difference in genotype distribution was found. In patients with mild symptoms, carriers of the GG genotype of rs2070788 had significantly higher total bilirubin levels than carriers of the AA genotype. Similarly, carriers of the TT genotype of rs2285666 had significantly higher activated partial thromboplastin time and international normalized ratio, and lower lactate dehydrogenase levels compared with the CC genotype. Among patients with severe symptoms, carriers of the GG genotype showed significantly higher potassium levels than carriers of the AA genotype, while carriers of the TT genotype showed significantly higher erythrocyte count as well as hemoglobin and hematocrit levels compared with the CC genotype. Conclusion: This study highlights the role of genetic factors, particularly SNPs in the ACE2 and TMPRSS2 genes, in determining COVID-19 severity, aiding patient risk assessment and prognosis. |
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| المشرفين على المادة: | EC 3.4.21.- (Serine Endopeptidases) EC 3.4.17.23 (Angiotensin-Converting Enzyme 2) EC 3.4.21.- (TMPRSS2 protein, human) 0 (Biomarkers) EC 3.4.17.23 (ACE2 protein, human) |
| تواريخ الأحداث: | Date Created: 20240613 Date Completed: 20240613 Latest Revision: 20240615 |
| رمز التحديث: | 20240615 |
| مُعرف محوري في PubMed: | PMC11157263 |
| PMID: | 38868968 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1332-8166 |
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