دورية أكاديمية
Data derived extrapolation factors (DDEFs) for rat to human interspecies extrapolation for the HPPD inhibitor mesotrione.
العنوان: | Data derived extrapolation factors (DDEFs) for rat to human interspecies extrapolation for the HPPD inhibitor mesotrione. |
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المؤلفون: | Pecquet AM; Product Safety, Syngenta Crop Protection LLC, Greensboro, NC, USA., Bridgwood K; Syngenta Jealott's Hill International Research Centre, Bracknell, UK., Cowie D; Syngenta Jealott's Hill International Research Centre, Bracknell, UK., Hofstra A; Syngenta Canada Inc, Guelph, Canada., Wu Y; Product Safety, Syngenta Crop Protection LLC, Greensboro, NC, USA., Whalley S; Syngenta Jealott's Hill International Research Centre, Bracknell, UK., Webb SD; Syngenta Jealott's Hill International Research Centre, Bracknell, UK. |
المصدر: | Critical reviews in toxicology [Crit Rev Toxicol] 2024 Jul; Vol. 54 (6), pp. 418-429. Date of Electronic Publication: 2024 Jun 13. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8914275 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1547-6898 (Electronic) Linking ISSN: 10408444 NLM ISO Abbreviation: Crit Rev Toxicol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Boca Raton, Fla. : CRC Press, c1980- |
مواضيع طبية MeSH: | Cyclohexanones*/toxicity , 4-Hydroxyphenylpyruvate Dioxygenase*/antagonists & inhibitors, Humans ; Animals ; Rats ; Risk Assessment ; Species Specificity ; Herbicides/toxicity ; Toxicokinetics ; Adverse Outcome Pathways |
مستخلص: | In the risk assessment of agrochemicals, there has been a historical paucity of using data to refine the default adjustment factors, even though large datasets are available to support this. The current state of the science for addressing uncertainty regarding animal to human extrapolation (AF |
فهرسة مساهمة: | Keywords: 4-hydroxyphenol pyruvate dioxygenase (HHPD); Data derived extrapolation factor (DDEF); chemical specific adjustment factor (CSAF); human health risk assessment (HHRA); mesotrione |
المشرفين على المادة: | 0 (Cyclohexanones) 48TR68G21T (mesotrione) EC 1.13.11.27 (4-Hydroxyphenylpyruvate Dioxygenase) 0 (Herbicides) |
تواريخ الأحداث: | Date Created: 20240613 Date Completed: 20240712 Latest Revision: 20240718 |
رمز التحديث: | 20240718 |
DOI: | 10.1080/10408444.2024.2353174 |
PMID: | 38869005 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1547-6898 |
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DOI: | 10.1080/10408444.2024.2353174 |