دورية أكاديمية
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Causal evidence for cholinergic stabilization of attractor landscape dynamics.

التفاصيل البيبلوغرافية
العنوان: Causal evidence for cholinergic stabilization of attractor landscape dynamics.
المؤلفون: Taylor NL; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia., Whyte CJ; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia., Munn BR; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia., Chang C; Vanderbilt School of Engineering, Vanderbilt University, Nashville, TN, USA., Lizier JT; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia; School of Computer Science, The University of Sydney, Sydney, NSW, Australia., Leopold DA; Neurophysiology Imaging Facility, National Institute of Mental Health, Washington DC, USA; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda MD, USA., Turchi JN; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda MD, USA., Zaborszky L; Centre for Molecular & Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ, USA., Műller EJ; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia., Shine JM; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia. Electronic address: mac.shine@sydney.edu.au.
المصدر: Cell reports [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114359. Date of Electronic Publication: 2024 Jun 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Magnetic Resonance Imaging*, Animals ; Basal Nucleus of Meynert/physiology ; Basal Nucleus of Meynert/metabolism ; Acetylcholine/metabolism ; Macaca mulatta ; Male ; Cholinergic Neurons/physiology ; Cholinergic Neurons/metabolism ; Cerebral Cortex/physiology ; Cerebral Cortex/metabolism ; Neurons/metabolism ; Neurons/physiology ; Models, Neurological
مستخلص: There is substantial evidence that neuromodulatory systems critically influence brain state dynamics; however, most work has been purely descriptive. Here, we quantify, using data combining local inactivation of the basal forebrain with simultaneous measurement of resting-state fMRI activity in the macaque, the causal role of long-range cholinergic input to the stabilization of brain states in the cerebral cortex. Local inactivation of the nucleus basalis of Meynert (nbM) leads to a decrease in the energy barriers required for an fMRI state transition in cortical ongoing activity. Moreover, the inactivation of particular nbM sub-regions predominantly affects information transfer in cortical regions known to receive direct anatomical projections. We demonstrate these results in a simple neurodynamical model of cholinergic impact on neuronal firing rates and slow hyperpolarizing adaptation currents. We conclude that the cholinergic system plays a critical role in stabilizing macroscale brain state dynamics.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: ZIC MH002899 United States ImNIH Intramural NIH HHS
فهرسة مساهمة: Keywords: CP: Neuroscience; acetylcholine; attractor landscape; brain states; cholinergic; dynamics; fMRI; neural mass model; neuromodulation
المشرفين على المادة: N9YNS0M02X (Acetylcholine)
تواريخ الأحداث: Date Created: 20240613 Date Completed: 20240701 Latest Revision: 20240719
رمز التحديث: 20240719
مُعرف محوري في PubMed: PMC11255396
DOI: 10.1016/j.celrep.2024.114359
PMID: 38870015
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2024.114359