دورية أكاديمية
Causal evidence for cholinergic stabilization of attractor landscape dynamics.
العنوان: | Causal evidence for cholinergic stabilization of attractor landscape dynamics. |
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المؤلفون: | Taylor NL; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia., Whyte CJ; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia., Munn BR; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia., Chang C; Vanderbilt School of Engineering, Vanderbilt University, Nashville, TN, USA., Lizier JT; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia; School of Computer Science, The University of Sydney, Sydney, NSW, Australia., Leopold DA; Neurophysiology Imaging Facility, National Institute of Mental Health, Washington DC, USA; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda MD, USA., Turchi JN; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda MD, USA., Zaborszky L; Centre for Molecular & Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ, USA., Műller EJ; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia., Shine JM; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia. Electronic address: mac.shine@sydney.edu.au. |
المصدر: | Cell reports [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114359. Date of Electronic Publication: 2024 Jun 13. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
مواضيع طبية MeSH: | Magnetic Resonance Imaging*, Animals ; Basal Nucleus of Meynert/physiology ; Basal Nucleus of Meynert/metabolism ; Acetylcholine/metabolism ; Macaca mulatta ; Male ; Cholinergic Neurons/physiology ; Cholinergic Neurons/metabolism ; Cerebral Cortex/physiology ; Cerebral Cortex/metabolism ; Neurons/metabolism ; Neurons/physiology ; Models, Neurological |
مستخلص: | There is substantial evidence that neuromodulatory systems critically influence brain state dynamics; however, most work has been purely descriptive. Here, we quantify, using data combining local inactivation of the basal forebrain with simultaneous measurement of resting-state fMRI activity in the macaque, the causal role of long-range cholinergic input to the stabilization of brain states in the cerebral cortex. Local inactivation of the nucleus basalis of Meynert (nbM) leads to a decrease in the energy barriers required for an fMRI state transition in cortical ongoing activity. Moreover, the inactivation of particular nbM sub-regions predominantly affects information transfer in cortical regions known to receive direct anatomical projections. We demonstrate these results in a simple neurodynamical model of cholinergic impact on neuronal firing rates and slow hyperpolarizing adaptation currents. We conclude that the cholinergic system plays a critical role in stabilizing macroscale brain state dynamics. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
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معلومات مُعتمدة: | ZIC MH002899 United States ImNIH Intramural NIH HHS |
فهرسة مساهمة: | Keywords: CP: Neuroscience; acetylcholine; attractor landscape; brain states; cholinergic; dynamics; fMRI; neural mass model; neuromodulation |
المشرفين على المادة: | N9YNS0M02X (Acetylcholine) |
تواريخ الأحداث: | Date Created: 20240613 Date Completed: 20240701 Latest Revision: 20240719 |
رمز التحديث: | 20240719 |
مُعرف محوري في PubMed: | PMC11255396 |
DOI: | 10.1016/j.celrep.2024.114359 |
PMID: | 38870015 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2211-1247 |
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DOI: | 10.1016/j.celrep.2024.114359 |