دورية أكاديمية
Dietary supplementations to mitigate the cardiopulmonary effects of air pollution toxicity: A systematic review of clinical trials.
العنوان: | Dietary supplementations to mitigate the cardiopulmonary effects of air pollution toxicity: A systematic review of clinical trials. |
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المؤلفون: | Ilaghi M; Institute of Neuropharmacology, Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran., Kafi F; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Shafiei M; Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Zangiabadian M; Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Nasiri MJ; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. |
المصدر: | PloS one [PLoS One] 2024 Jun 13; Vol. 19 (6), pp. e0304402. Date of Electronic Publication: 2024 Jun 13 (Print Publication: 2024). |
نوع المنشور: | Journal Article; Systematic Review |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
مواضيع طبية MeSH: | Dietary Supplements* , Air Pollution*/adverse effects, Humans ; Antioxidants/administration & dosage ; Cardiovascular Diseases/prevention & control ; Clinical Trials as Topic ; Fish Oils/administration & dosage ; Ascorbic Acid/administration & dosage |
مستخلص: | Background: There is a consistent association between exposure to air pollution and elevated rates of cardiopulmonary illnesses. As public health activities emphasize the paramount need to reduce exposure, it is crucial to examine strategies like the antioxidant diet that could potentially protect individuals who are unavoidably exposed. Methods: A systematic search was performed in PubMed/Medline, EMBASE, CENTRAL, and ClinicalTrials.gov up to March 31, 2023, for clinical trials assessing dietary supplements against cardiovascular (blood pressure, heart rate, heart rate variability, brachial artery diameter, flow-mediated dilation, and lipid profile) or pulmonary outcomes (pulmonary function and airway inflammation) attributed to air pollution exposure. Results: After reviewing 4681 records, 18 studies were included. There were contradictory findings on the effects of fish oil and olive oil supplementations on cardiovascular outcomes. Although with limited evidence, fish oil offered protection against pulmonary dysfunction induced by pollutants. Most studies on vitamin C did not find protective cardiovascular effects; however, the combination of vitamin C and E offered protective effects against pulmonary dysfunction but showed conflicting results for cardiovascular outcomes. Other supplements like sulforaphane, L-arginine, n-acetylcysteine, and B vitamins showed potential beneficial effects but need further research due to the limited number of existing trials. Conclusions: Although more research is needed to determine the efficacy and optimal dose of anti-inflammatory and antioxidant dietary supplements against air pollution toxicity, this low-cost preventative strategy has the potential to offer protection against outcomes of air pollution exposure. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2024 Ilaghi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
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المشرفين على المادة: | 0 (Antioxidants) 0 (Fish Oils) PQ6CK8PD0R (Ascorbic Acid) |
تواريخ الأحداث: | Date Created: 20240613 Date Completed: 20240613 Latest Revision: 20240620 |
رمز التحديث: | 20240620 |
مُعرف محوري في PubMed: | PMC11175466 |
DOI: | 10.1371/journal.pone.0304402 |
PMID: | 38870164 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1932-6203 |
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DOI: | 10.1371/journal.pone.0304402 |