دورية أكاديمية
أعرض في EDS

Association between cannabis use disorder and greater apathy in adults with HIV.

التفاصيل البيبلوغرافية
العنوان: Association between cannabis use disorder and greater apathy in adults with HIV.
المؤلفون: Britton MK; Center for Cognitive Aging and Memory, University of Florida, 1249 Center Drive, Gainesville, FL 32603, United States; Department of Epidemiology, University of Florida, 2004 Mowry Road, Gainesville, FL 32603, United States. Electronic address: mark.britton@ufl.edu., DeFelice J; Center for Cognitive Aging and Memory, University of Florida, 1249 Center Drive, Gainesville, FL 32603, United States., Porges EC; Center for Cognitive Aging and Memory, University of Florida, 1249 Center Drive, Gainesville, FL 32603, United States., Cohen R; Center for Cognitive Aging and Memory, University of Florida, 1249 Center Drive, Gainesville, FL 32603, United States., Li Y; Department of Epidemiology, University of Florida, 2004 Mowry Road, Gainesville, FL 32603, United States., Wang Y; Department of Epidemiology, University of Florida, 2004 Mowry Road, Gainesville, FL 32603, United States., Ibañez GE; Department of Epidemiology, Florida International University, 11200 SW 8th Street, Miami, FL 33199, United States., Somboonwit C; Department of Internal Medicine, University of South Florida, 13330 USF Laurel Drive, Tampa, FL 33612, United States., Cook RL; Department of Epidemiology, University of Florida, 2004 Mowry Road, Gainesville, FL 32603, United States.
المصدر: Drug and alcohol dependence [Drug Alcohol Depend] 2024 Aug 01; Vol. 261, pp. 111354. Date of Electronic Publication: 2024 Jun 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 7513587 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0046 (Electronic) Linking ISSN: 03768716 NLM ISO Abbreviation: Drug Alcohol Depend Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier
Original Publication: Lausanne, Elsevier Sequoia.
مواضيع طبية MeSH: Apathy* , HIV Infections*/psychology , HIV Infections*/epidemiology , HIV Infections*/complications , Marijuana Abuse*/epidemiology , Marijuana Abuse*/psychology, Humans ; Male ; Female ; Adult ; Middle Aged ; Depression/psychology ; Depression/epidemiology
مستخلص: Background: Apathy is prevalent among people with HIV (PWH) and is associated with poor clinical outcomes. Cannabis use and Cannabis Use Disorder (CUD) are also disproportionately prevalent among PWH. CUD and younger onset of cannabis use may be linked to apathy in the general population; however, patterns of use most strongly associated with apathy have not been firmly established, and it is unclear whether cannabis use is linked to apathy in PWH.
Methods: We examined associations in 311 adult PWH between Apathy Evaluation Scale-Self (AES-S) scores and CUD history (current/past/no CUD/no cannabis use) and between AES-S scores and age of CUD onset (adolescent-onset/adult-onset). We also examined robustness of associations to adjustment for depressive symptoms (which may overlap with apathy symptoms) and alcohol use.
Results: Current CUD was associated with greater AES-S scores relative to cannabis users with no CUD history (β = 2.13, 95 % CI = 0.37-3.90, p = 0.018). Adolescent-onset CUD was not associated with greater apathy relative to adult-onset CUD (β = 0.56, 95 % CI = -2.57 - 3.68, p = 0.7). Associations became nonsignificant after adjustment for depressive symptoms, but not after adjustment for alcohol use. Alcohol use was correlated with apathy (r = 0.19, 95 % CI: 0.076-0.29, p = 0.001).
Conclusions: Cannabis Use Disorder and at-risk alcohol use are associated with apathy among PWH; this finding highlights the need for substance use disorder prevention and treatment among PWH.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
معلومات مُعتمدة: R01 DA042069 United States DA NIDA NIH HHS; T32 AA025877 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: Apathy; Cannabis; Cannabis use disorder; HIV
تواريخ الأحداث: Date Created: 20240613 Date Completed: 20240713 Latest Revision: 20240713
رمز التحديث: 20240714
DOI: 10.1016/j.drugalcdep.2024.111354
PMID: 38870567
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0046
DOI:10.1016/j.drugalcdep.2024.111354