دورية أكاديمية
Skin anti-aging potential of Launaea procumbens extract: Antioxidant and enzyme inhibition activities supported by ADMET and molecular docking studies.
| العنوان: | Skin anti-aging potential of Launaea procumbens extract: Antioxidant and enzyme inhibition activities supported by ADMET and molecular docking studies. |
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| المؤلفون: | Khojah H; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Ahmed SR; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Alharbi SY; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., AlSabeelah KK; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Alrayyes HY; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Almusayyab KB; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Alrawiliy SR; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Alshammari RM; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Qasim S; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia. |
| المصدر: | Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2024 Jul; Vol. 32 (7), pp. 102107. Date of Electronic Publication: 2024 May 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Saudi Pharmaceutical Society Country of Publication: Saudi Arabia NLM ID: 9705695 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1319-0164 (Print) Linking ISSN: 13190164 NLM ISO Abbreviation: Saudi Pharm J Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Riyadh : Saudi Pharmaceutical Society Original Publication: Riyadh, Kingdom of Saudi Arabia : The Society, |
| مستخلص: | Aging is a natural process that occurs in all living organisms. Particularly, the skin embodies aging since it serves as a barrier between the body and its surroundings. Previously, we reported the wound healing effect of Launaea procumbens and identified compounds therein. The study aims to explore the skin anti-aging properties of the plant extract. To that effect, the antioxidant potential of L. procumbens methanolic extract (LPM) was assessed using two complementary DPPH and FRAP assays. The enzyme inhibitory effect of the extract on collagenase, elastase, hyaluronidase, and tyrosinase was evaluated to assess the direct skin anti-aging effects. Similarly, the anti-inflammatory activity was evaluated to explore the indirect anti-aging effects via the assessment of extract inhibitory effects on cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). In addition, ADMET and molecular docking studies were performed to explore the interaction mechanisms of identified compounds in LPM with target enzymes. LPM demonstrated significant antioxidant activity in DPPH (IC Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Author(s).) |
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| فهرسة مساهمة: | Keywords: ADMET; Anti-aging; Docking; Launaea procumbens |
| تواريخ الأحداث: | Date Created: 20240614 Latest Revision: 20240615 |
| رمز التحديث: | 20240615 |
| مُعرف محوري في PubMed: | PMC11170203 |
| DOI: | 10.1016/j.jsps.2024.102107 |
| PMID: | 38873335 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1319-0164 |
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| DOI: | 10.1016/j.jsps.2024.102107 |