دورية أكاديمية
Spatial lipidomics maps brain alterations associated with mild traumatic brain injury.
| العنوان: | Spatial lipidomics maps brain alterations associated with mild traumatic brain injury. |
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| المؤلفون: | Leontyev D; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, United States., Pulliam AN; Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, United States., Ma X; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, United States., Gaul DA; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, United States.; Parker H. Petit Institute for Bioengineering and Bioscience, Atlanta, GA, United States., LaPlaca MC; Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, United States.; Parker H. Petit Institute for Bioengineering and Bioscience, Atlanta, GA, United States., Fernández FM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, United States.; Parker H. Petit Institute for Bioengineering and Bioscience, Atlanta, GA, United States. |
| المصدر: | Frontiers in chemistry [Front Chem] 2024 May 30; Vol. 12, pp. 1394064. Date of Electronic Publication: 2024 May 30 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101627988 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2646 (Print) Linking ISSN: 22962646 NLM ISO Abbreviation: Front Chem Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2013]- |
| مستخلص: | Traumatic brain injury (TBI) is a global public health problem with 50-60 million incidents per year, most of which are considered mild (mTBI) and many of these repetitive (rmTBI). Despite their massive implications, the pathologies of mTBI and rmTBI are not fully understood, with a paucity of information on brain lipid dysregulation following mild injury event(s). To gain more insight on mTBI and rmTBI pathology, a non-targeted spatial lipidomics workflow utilizing high resolution mass spectrometry imaging was developed to map brain region-specific lipid alterations in rats following injury. Discriminant multivariate models were created for regions of interest including the hippocampus, cortex, and corpus callosum to pinpoint lipid species that differentiated between injured and sham animals. A multivariate model focused on the hippocampus region differentiated injured brain tissues with an area under the curve of 0.99 using only four lipid species. Lipid classes that were consistently discriminant included polyunsaturated fatty acid-containing phosphatidylcholines (PC), lysophosphatidylcholines (LPC), LPC-plasmalogens (LPC-P) and PC potassium adducts. Many of the polyunsaturated fatty acid-containing PC and LPC-P selected have never been previously reported as altered in mTBI. The observed lipid alterations indicate that neuroinflammation and oxidative stress are important pathologies that could serve to explain cognitive deficits associated with rmTBI. Therapeutics which target or attenuate these pathologies may be beneficial to limit persistent damage following a mild brain injury event. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Leontyev, Pulliam, Ma, Gaul, LaPlaca and Fernández.) |
| التعليقات: | Update of: bioRxiv. 2024 Mar 12:2024.01.25.577203. doi: 10.1101/2024.01.25.577203. (PMID: 38328252) |
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| معلومات مُعتمدة: | R01 NS101909 United States NS NINDS NIH HHS; T32 GM145735 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: controlled cortical impact; fourier transform ion cyclotron resonance; mass spectrometry imaging; mild traumatic brain injury; spatial lipidomics |
| تواريخ الأحداث: | Date Created: 20240614 Latest Revision: 20240624 |
| رمز التحديث: | 20240624 |
| مُعرف محوري في PubMed: | PMC11169706 |
| DOI: | 10.3389/fchem.2024.1394064 |
| PMID: | 38873407 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-2646 |
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| DOI: | 10.3389/fchem.2024.1394064 |