التفاصيل البيبلوغرافية
| العنوان: |
Morphology, repulsion, and ordering of red blood cells in viscoelastic flows under confinement. |
| المؤلفون: |
Recktenwald SM; Dynamics of Fluids, Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany. steffen.recktenwald@uni-saarland.de.; Micro/Bio/Nanofluidics Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa 904-0495, Japan., Rashidi Y; Dynamics of Fluids, Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany. steffen.recktenwald@uni-saarland.de., Graham I; Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104, USA., Arratia PE; Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104, USA., Del Giudice F; Complex Fluid Research Group, Department of Chemical Engineering, Faculty of Science and Engineering, Swansea University, Swansea SA1 8EN, UK., Wagner C; Dynamics of Fluids, Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany. steffen.recktenwald@uni-saarland.de.; Physics and Materials Science Research Unit, University of Luxembourg, L-1511 Luxembourg, Luxembourg. |
| المصدر: |
Soft matter [Soft Matter] 2024 Jun 26; Vol. 20 (25), pp. 4950-4963. Date of Electronic Publication: 2024 Jun 26. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101295070 Publication Model: Electronic Cited Medium: Internet ISSN: 1744-6848 (Electronic) Linking ISSN: 1744683X NLM ISO Abbreviation: Soft Matter Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Cambridge, England : Royal Society of Chemistry, 2005- |
| مواضيع طبية MeSH: |
Erythrocytes*/cytology , Elasticity*, Viscosity ; Humans ; Hydrodynamics ; Microfluidics |
| مستخلص: |
Red blood cells (RBC), the primary carriers of oxygen in the body, play a crucial role across several biomedical applications, while also being an essential model system of a deformable object in the microfluidics and soft matter fields. However, RBC behavior in viscoelastic liquids, which holds promise in enhancing microfluidic diagnostic applications, remains poorly studied. We here show that using viscoelastic polymer solutions as a suspending carrier causes changes in the clustering and shape of flowing RBC in microfluidic flows when compared to a standard Newtonian suspending liquid. Additionally, when the local RBC concentration increases to a point where hydrodynamic interactions take place, we observe the formation of equally-spaced RBC structures, resembling the viscoelasticity-driven ordered particles observed previously in the literature, thus providing the first experimental evidence of viscoelasticity-driven cell ordering. The observed RBC ordering, unaffected by polymer molecular architecture, persists as long as the surrounding medium exhibits shear-thinning, viscoelastic properties. Complementary numerical simulations reveal that viscoelasticity-induced repulsion between RBCs leads to equidistant structures, with shear-thinning modulating this effect. Our results open the way for the development of new biomedical technologies based on the use of viscoelastic liquids while also clarifying fundamental aspects related to multibody hydrodynamic interactions in viscoelastic microfluidic flows. |
| تواريخ الأحداث: |
Date Created: 20240614 Date Completed: 20240626 Latest Revision: 20240626 |
| رمز التحديث: |
20240626 |
| DOI: |
10.1039/d4sm00446a |
| PMID: |
38873747 |
| قاعدة البيانات: |
MEDLINE |
