دورية أكاديمية
Urinary eosinophil-derived neurotoxin is associated with reduced lung function in pediatric asthma.
| العنوان: | Urinary eosinophil-derived neurotoxin is associated with reduced lung function in pediatric asthma. |
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| المؤلفون: | Omony J; Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Munich, Germany.; German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany., Thölken C; Center for Synthetic Microbiology (SYNMIKRO), Philipps-University Marburg, Marburg, Germany., Salimi A; Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany., Laubhahn K; German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany.; Department of Paediatric Allergology, Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany., Illi S; Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Munich, Germany.; German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany., Weckmann M; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Großhansdorf, Germany.; University Children's Hospital, Luebeck, Germany., Grychtol R; Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany., Rabe KF; German Center for Lung Research (DZL), LungenClinic Grosshansdorf GmbH, Airway Research Center North (ARCN), Grosshansdorf, Germany., Thiele D; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Großhansdorf, Germany.; Institute of Medical Biometry and Statistics (IMBS), University Medical Center Schleswig-Holstein, Luebeck, Germany., Foth S; University Children's Hospital Marburg, University of Marburg, Marburg, Germany.; German Center for Lung Research (DZL), University of Giessen, Marburg Lung Center (UGMLC), Giessen, Germany., Weber S; University Children's Hospital Marburg, University of Marburg, Marburg, Germany.; German Center for Lung Research (DZL), University of Giessen, Marburg Lung Center (UGMLC), Giessen, Germany., Brinkmann F; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Großhansdorf, Germany.; University Children's Hospital, Luebeck, Germany., Kopp MV; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Großhansdorf, Germany.; University Children's Hospital, Luebeck, Germany.; Department of Pediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland., Hansen G; Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany., Renz H; Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany.; Kilimanjaro Christian Medical University College (KCMUCo), Moshi, Tanzania., von Mutius E; Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Munich, Germany.; German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany.; Department of Paediatric Allergology, Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany., Schaub B; German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany.; Department of Paediatric Allergology, Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany., Skevaki C; Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany.; German Center for Lung Research (DZL), University of Giessen, Marburg Lung Center (UGMLC), Giessen, Germany. |
| مؤلفون مشاركون: | ALLIANCE Study Group |
| المصدر: | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Pediatr Allergy Immunol] 2024 Jun; Vol. 35 (6), pp. e14172. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Publishing Country of Publication: England NLM ID: 9106718 Publication Model: Print Cited Medium: Internet ISSN: 1399-3038 (Electronic) Linking ISSN: 09056157 NLM ISO Abbreviation: Pediatr Allergy Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2010->: Oxford, UK : Blackwell Publishing Original Publication: Copenhagen : Munksgaard, c1990- |
| مواضيع طبية MeSH: | Asthma*/urine , Asthma*/diagnosis , Asthma*/physiopathology , Eosinophil-Derived Neurotoxin*/urine , Biomarkers*/urine, Humans ; Male ; Female ; Child ; Child, Preschool ; Eosinophils/immunology ; Immunoglobulin E/blood ; Lung/physiopathology ; Respiratory Function Tests/methods ; Adolescent |
| مستخلص: | Introduction: Eosinophil-derived neurotoxin (EDN) is a biomarker for eosinophilic activation. Urinary (u) EDN may allow non-invasive monitoring of asthma, but clinical recommendations are lacking. We assessed the potential of uEDN as a marker of disease activity in pediatric asthma. Methods: We assessed urine samples of 371 children from the German ALLIANCE study cohort, from which we had: 169 preschool wheezers (<6 years), 80 asthmatics (≥6 years), and 122 healthy controls using the ImmunoCAP™ EDN Assay. Creatinine (Cr)-adjusted uEDN values were analyzed using correlations, association tests, (non) parametric statistics, multiple linear, and multivariable regression. Results: uEDN/uCr values were higher in atopic versus non-atopic preschool-aged subjects (p = .035) and associated with the sum of allergen-specific IgE in younger (r = 0.24, p = .003), and older subjects (r = 0.23, p = .043). uEDN/uCr was marginally a good determinant for atopy (p = .078, for subjects aged <6 years, and p = .058 for subjects ≥6 years). Children with the T2-high phenotype had higher uEDN/uCr (p < .001) versus T2-low-irrespective of using uEDN/uCr or blood eosinophils in combination to allergen sIgE for disease phenotyping. uEDN/uCr significantly correlated with reduced lung function among asthmatics (FEV Conclusions: uEDN/uCr may serve as a non-invasive biomarker for clinical features such as lung function in pediatric asthma. We highlight the utility of uEDN/uCr as a biomarker that can be easily assessed using widely available robust diagnostic immunoassays. (© 2024 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | 197785619 CS is supported by the Universities Giessen and Marburg Lung Center (UGMLC), the German Center for Lung Research (DZL), University Hospital Giessen and Marburg (UKGM) research funding according to article 2, section 3 cooperation agreement, and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)-SFB 1021; 284237345 KFO 309; 428518790 SK 317/1-1; SCHA 997/9-1 German Research Foundation; SCHA 997/10-1 German Research Foundation; SCHA 997/11-1 German Research Foundation |
| فهرسة مساهمة: | Keywords: T2‐high phenotype; atopy; biomarker; children; eosinophil‐derived neurotoxin; preschool wheeze |
| المشرفين على المادة: | EC 3.1.- (Eosinophil-Derived Neurotoxin) 0 (Biomarkers) 37341-29-0 (Immunoglobulin E) |
| تواريخ الأحداث: | Date Created: 20240614 Date Completed: 20240614 Latest Revision: 20240614 |
| رمز التحديث: | 20240614 |
| DOI: | 10.1111/pai.14172 |
| PMID: | 38873905 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1399-3038 |
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| DOI: | 10.1111/pai.14172 |