دورية أكاديمية
أعرض في EDS

Molecular epidemiology and risk factors associated with BK and JC polyomavirus urinary shedding after kidney allograft.

التفاصيل البيبلوغرافية
العنوان: Molecular epidemiology and risk factors associated with BK and JC polyomavirus urinary shedding after kidney allograft.
المؤلفون: Demey B; Department of Virology, CHU Amiens-Picardie, Amiens, France.; AGIR Laboratory UR4294, Université Picardie Jules Verne, Amiens, France., Aubry A; Department of Virology, CHU Amiens-Picardie, Amiens, France.; AGIR Laboratory UR4294, Université Picardie Jules Verne, Amiens, France., Descamps V; AGIR Laboratory UR4294, Université Picardie Jules Verne, Amiens, France., Morel V; AGIR Laboratory UR4294, Université Picardie Jules Verne, Amiens, France., Le MHH; Department of Virology, CHU Amiens-Picardie, Amiens, France., Presne C; Department of Nephrology, Dialysis, and Transplantation, CHU Amiens-Picardie, Amiens, France., Brazier F; Department of Nephrology, Dialysis, and Transplantation, CHU Amiens-Picardie, Amiens, France.; MP3CV Laboratory EA7517, Jules Verne University of Picardie, Amiens, France., Helle F; AGIR Laboratory UR4294, Université Picardie Jules Verne, Amiens, France., Brochot E; Department of Virology, CHU Amiens-Picardie, Amiens, France.; AGIR Laboratory UR4294, Université Picardie Jules Verne, Amiens, France.
المصدر: Journal of medical virology [J Med Virol] 2024 Jun; Vol. 96 (6), pp. e29742.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss.
مواضيع طبية MeSH: BK Virus*/genetics , BK Virus*/isolation & purification , Polyomavirus Infections*/epidemiology , Polyomavirus Infections*/virology , Polyomavirus Infections*/urine , Kidney Transplantation*/adverse effects , JC Virus*/genetics , JC Virus*/isolation & purification , Genotype* , Molecular Epidemiology*, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Risk Factors ; Case-Control Studies ; Adult ; Virus Shedding ; Aged ; Transplant Recipients/statistics & numerical data ; Tumor Virus Infections/epidemiology ; Tumor Virus Infections/virology ; Tumor Virus Infections/urine ; DNA, Viral/urine ; DNA, Viral/genetics ; Allografts/virology
مستخلص: Polyomaviruses BK (BKPyV) and JC (JCPyV), belonging to the Polyomaviridae, are responsible for human pathologies. In kidney transplant recipients, BKPyV replication can lead to irreversible nephron damage whereas JCPyV replication remains asymptomatic. Concomitant replication is rare and potential competition between the infections has been described. The aim of this retrospective case-control study was to describe the molecular epidemiology and risk factors associated with BKPyV and JCPyV replication in a cohort of kidney transplant recipients. In total, 655 urine samples from 460 patients were tested for BKPyV and JCPyV DNA. Positive samples were submitted to strain genotyping. Demographic and clinical characteristics were also compared. Isolated JCPyV and BKPyV was found in 16.5% and 23.3% of patients, respectively; co-replication was rare (3.9%). BKPyV strains Ib-2, Ib-1, and IVc-2 were the most prevalent. JCPyV strains mostly belonged to genotypes 4 and 1B. During follow-up, JCPyV shedding significantly reduced the risk of BKPyV DNAuria, with an odds ratio of 0.57 (95% confidence interval: 0.35-0.99), and was associated with better prognosis than BKPyV replication, based on the estimated glomerular filtration rate. Molecular epidemiology of BKPyV and JCPyV strains in our region was similar to previous studies. This study suggests that JCPyV is benign and appears to limit damaging BKPyV replication. JCPyV DNAuria screening could thus be a useful strategy to predict BKPyV-related outcomes.
(© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: BK Virus; JC Virus; kidney transplantation; molecular epidemiology; polyomavirus; risk factors
المشرفين على المادة: 0 (DNA, Viral)
تواريخ الأحداث: Date Created: 20240614 Date Completed: 20240614 Latest Revision: 20240614
رمز التحديث: 20240614
DOI: 10.1002/jmv.29742
PMID: 38874263
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-9071
DOI:10.1002/jmv.29742