دورية أكاديمية
Antimalarial activity of cecropin antimicrobial peptides derived from Anopheles mosquitoes.
| العنوان: | Antimalarial activity of cecropin antimicrobial peptides derived from Anopheles mosquitoes. |
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| المؤلفون: | Lou J; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China., Zhang D; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China., Wu J; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China., Zhu G; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China., Zhang M; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China., Tang J; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China., Fang Y; Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., He X; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China., Cao J; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China. |
| المصدر: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Jul 09; Vol. 68 (7), pp. e0031124. Date of Electronic Publication: 2024 Jun 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology |
| مواضيع طبية MeSH: | Antimalarials*/pharmacology , Anopheles*/drug effects , Anopheles*/parasitology , Plasmodium falciparum*/drug effects , Plasmodium berghei*/drug effects, Animals ; Mice ; Cecropins/pharmacology ; Antimicrobial Peptides/pharmacology ; Antimicrobial Peptides/chemistry ; Malaria/drug therapy ; Malaria/parasitology ; Erythrocytes/drug effects ; Erythrocytes/parasitology ; Humans ; Mosquito Vectors/drug effects ; Mosquito Vectors/parasitology ; Female ; Insect Proteins/pharmacology ; Drug Resistance/drug effects ; Chloroquine/pharmacology ; Parasitic Sensitivity Tests |
| مستخلص: | The emergence of clinically drug-resistant malaria parasites requires the urgent development of new drugs. Mosquitoes are vectors of multiple pathogens and have developed resistance mechanisms against them, which often involve antimicrobial peptides (AMPs). An-cecB is an AMP of the malaria-transmitting mosquito genus Anopheles , and we herein report its antimalarial activity against Plasmodium falciparum 3D7, the artemisinin-resistant strain 803, and the chloroquine-resistant strain Dd2 in vitro . We also demonstrate its anti-parasite activity in vivo , using the rodent malaria parasite Plasmodium berghei (ANKA). We show that An-cecB displays potent antimalarial activity and that its mechanism of action may occur through direct killing of the parasite or through interaction with infected red blood cell membranes. Unfortunately, An-cecB was found to be cytotoxic to mammalian cells and had poor antimalarial activity in vivo . However, its truncated peptide An-cecB-1 retained most of its antimalarial activity and avoided its cytotoxicity in vitro . An-cecB-1 also showed better antimalarial activity in vivo . Mosquito-derived AMPs may provide new ideas for the development of antimalarial drugs against drug-resistant parasites, and An-cecB has potential use as a template for antimalarial peptides. Competing Interests: The authors declare no conflict of interest. |
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| معلومات مُعتمدة: | 82172302 MOST | National Natural Science Foundation of China (NSFC); 32002311 MOST | National Natural Science Foundation of China (NSFC); 82320108014 MOST | National Natural Science Foundation of China (NSFC); 82302562 MOST | National Natural Science Foundation of China (NSFC); 82102424 MOST | National Natural Science Foundation of China (NSFC); 82372275 MOST | National Natural Science Foundation of China (NSFC); 2023YFA1801004 MOST | National Key Research and Development Program of China (NKPs) |
| فهرسة مساهمة: | Keywords: Anopheles; antimalarial peptides; antimicrobial peptides; drug resistant; malaria |
| المشرفين على المادة: | 0 (Antimalarials) 0 (Cecropins) 0 (Antimicrobial Peptides) 0 (Insect Proteins) 886U3H6UFF (Chloroquine) |
| تواريخ الأحداث: | Date Created: 20240614 Date Completed: 20240709 Latest Revision: 20240711 |
| رمز التحديث: | 20240711 |
| مُعرف محوري في PubMed: | PMC11232398 |
| DOI: | 10.1128/aac.00311-24 |
| PMID: | 38874346 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-6596 |
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| DOI: | 10.1128/aac.00311-24 |