دورية أكاديمية
Mean Apparent Propagator MRI: Quantitative Assessment of Tumor-Stroma Ratio in Invasive Ductal Breast Carcinoma.
| العنوان: | Mean Apparent Propagator MRI: Quantitative Assessment of Tumor-Stroma Ratio in Invasive Ductal Breast Carcinoma. |
|---|---|
| المؤلفون: | Zhang X; From the Department of Radiology (X.Z., Y.Q., W.J., Z.Y., J.S.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (X.Z., Y.Q., W.J., Z.Y., Q.L., Y.L., J.S.), and Department of Pathology (Q.L., Y.L.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, People's Republic of China; Department of Radiology, the First People's Hospital of Kashi Prefecture, Kashi, People's Republic of China (Y.Q.); Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, People's Republic of China (M.W., X.Y.); and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, People's Republic of China (G.Y.)., Qiu Y; From the Department of Radiology (X.Z., Y.Q., W.J., Z.Y., J.S.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (X.Z., Y.Q., W.J., Z.Y., Q.L., Y.L., J.S.), and Department of Pathology (Q.L., Y.L.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, People's Republic of China; Department of Radiology, the First People's Hospital of Kashi Prefecture, Kashi, People's Republic of China (Y.Q.); Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, People's Republic of China (M.W., X.Y.); and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, People's Republic of China (G.Y.)., Jiang W; From the Department of Radiology (X.Z., Y.Q., W.J., Z.Y., J.S.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (X.Z., Y.Q., W.J., Z.Y., Q.L., Y.L., J.S.), and Department of Pathology (Q.L., Y.L.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, People's Republic of China; Department of Radiology, the First People's Hospital of Kashi Prefecture, Kashi, People's Republic of China (Y.Q.); Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, People's Republic of China (M.W., X.Y.); and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, People's Republic of China (G.Y.)., Yang Z; From the Department of Radiology (X.Z., Y.Q., W.J., Z.Y., J.S.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (X.Z., Y.Q., W.J., Z.Y., Q.L., Y.L., J.S.), and Department of Pathology (Q.L., Y.L.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, People's Republic of China; Department of Radiology, the First People's Hospital of Kashi Prefecture, Kashi, People's Republic of China (Y.Q.); Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, People's Republic of China (M.W., X.Y.); and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, People's Republic of China (G.Y.)., Wang M; From the Department of Radiology (X.Z., Y.Q., W.J., Z.Y., J.S.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (X.Z., Y.Q., W.J., Z.Y., Q.L., Y.L., J.S.), and Department of Pathology (Q.L., Y.L.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, People's Republic of China; Department of Radiology, the First People's Hospital of Kashi Prefecture, Kashi, People's Republic of China (Y.Q.); Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, People's Republic of China (M.W., X.Y.); and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, People's Republic of China (G.Y.)., Li Q; From the Department of Radiology (X.Z., Y.Q., W.J., Z.Y., J.S.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (X.Z., Y.Q., W.J., Z.Y., Q.L., Y.L., J.S.), and Department of Pathology (Q.L., Y.L.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, People's Republic of China; Department of Radiology, the First People's Hospital of Kashi Prefecture, Kashi, People's Republic of China (Y.Q.); Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, People's Republic of China (M.W., X.Y.); and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, People's Republic of China (G.Y.)., Liu Y; From the Department of Radiology (X.Z., Y.Q., W.J., Z.Y., J.S.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (X.Z., Y.Q., W.J., Z.Y., Q.L., Y.L., J.S.), and Department of Pathology (Q.L., Y.L.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, People's Republic of China; Department of Radiology, the First People's Hospital of Kashi Prefecture, Kashi, People's Republic of China (Y.Q.); Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, People's Republic of China (M.W., X.Y.); and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, People's Republic of China (G.Y.)., Yan X; From the Department of Radiology (X.Z., Y.Q., W.J., Z.Y., J.S.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (X.Z., Y.Q., W.J., Z.Y., Q.L., Y.L., J.S.), and Department of Pathology (Q.L., Y.L.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, People's Republic of China; Department of Radiology, the First People's Hospital of Kashi Prefecture, Kashi, People's Republic of China (Y.Q.); Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, People's Republic of China (M.W., X.Y.); and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, People's Republic of China (G.Y.)., Yang G; From the Department of Radiology (X.Z., Y.Q., W.J., Z.Y., J.S.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (X.Z., Y.Q., W.J., Z.Y., Q.L., Y.L., J.S.), and Department of Pathology (Q.L., Y.L.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, People's Republic of China; Department of Radiology, the First People's Hospital of Kashi Prefecture, Kashi, People's Republic of China (Y.Q.); Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, People's Republic of China (M.W., X.Y.); and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, People's Republic of China (G.Y.)., Shen J; From the Department of Radiology (X.Z., Y.Q., W.J., Z.Y., J.S.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (X.Z., Y.Q., W.J., Z.Y., Q.L., Y.L., J.S.), and Department of Pathology (Q.L., Y.L.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, People's Republic of China; Department of Radiology, the First People's Hospital of Kashi Prefecture, Kashi, People's Republic of China (Y.Q.); Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, People's Republic of China (M.W., X.Y.); and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, People's Republic of China (G.Y.). |
| المصدر: | Radiology. Imaging cancer [Radiol Imaging Cancer] 2024 Jul; Vol. 6 (4), pp. e230165. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Radiological Society of North America, Inc Country of Publication: United States NLM ID: 101765309 Publication Model: Print Cited Medium: Internet ISSN: 2638-616X (Electronic) Linking ISSN: 2638616X NLM ISO Abbreviation: Radiol Imaging Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oak Brook, IL : Radiological Society of North America, Inc., [2019]- |
| مواضيع طبية MeSH: | Breast Neoplasms*/diagnostic imaging , Breast Neoplasms*/pathology , Carcinoma, Ductal, Breast*/diagnostic imaging , Carcinoma, Ductal, Breast*/pathology , Diffusion Magnetic Resonance Imaging*/methods, Humans ; Female ; Middle Aged ; Prospective Studies ; Sensitivity and Specificity ; Adult ; Breast/diagnostic imaging ; Breast/pathology ; Aged ; Magnetic Resonance Imaging/methods |
| مستخلص: | Purpose To determine whether metrics from mean apparent propagator (MAP) MRI perform better than apparent diffusion coefficient (ADC) value in assessing the tumor-stroma ratio (TSR) status in breast carcinoma. Materials and Methods From August 2021 to October 2022, 271 participants were prospectively enrolled (ClinicalTrials.gov identifier: NCT05159323) and underwent breast diffusion spectral imaging and diffusion-weighted imaging. MAP MRI metrics and ADC were derived from the diffusion MRI data. All participants were divided into high-TSR (stromal component < 50%) and low-TSR (stromal component ≥ 50%) groups based on pathologic examination. Clinicopathologic characteristics were collected, and MRI findings were assessed. Logistic regression was used to determine the independent variables for distinguishing TSR status. The area under the receiver operating characteristic curve (AUC) and sensitivity, specificity, and accuracy were compared between the MAP MRI metrics, either alone or combined with clinicopathologic characteristics, and ADC, using the DeLong and McNemar test. Results A total of 181 female participants (mean age, 49 years ± 10 [SD]) were included. All diffusion MRI metrics differed between the high-TSR and low-TSR groups ( P < .001 to P = .01). Radial non-Gaussianity from MAP MRI and lymphovascular invasion were significant independent variables for discriminating the two groups, with a higher AUC (0.81 [95% CI: 0.74, 0.87] vs 0.61 [95% CI: 0.53, 0.68], P < .001) and accuracy (138 of 181 [76%] vs 106 of 181 [59%], P < .001) than that of the ADC. Conclusion MAP MRI may serve as a better approach than conventional diffusion-weighted imaging in evaluating the TSR of breast carcinoma. Keywords: MR Diffusion-weighted Imaging, MR Imaging, Breast, Oncology ClinicalTrials.gov Identifier: NCT05159323 Supplemental material is available for this article. © RSNA, 2024. |
| References: | Trends Biotechnol. 2015 Apr;33(4):230-6. (PMID: 25708906) NMR Biomed. 2023 Aug;36(8):e4920. (PMID: 36912198) BMC Med Imaging. 2020 Nov 23;20(1):124. (PMID: 33228564) Breast Cancer Res Treat. 2018 Apr;168(3):601-612. (PMID: 29273955) Radiology. 2022 Mar;302(3):652-661. (PMID: 34874198) Brain. 2023 Apr 19;146(4):1602-1614. (PMID: 36130332) Clin Imaging. 2016 Sep-Oct;40(5):1047-54. (PMID: 27379441) Neuroimage. 2019 Oct 1;199:237-244. (PMID: 31163267) Br J Cancer. 2018 Jul;119(2):164-169. (PMID: 29755119) Neuroimage. 2016 Jul 1;134:365-385. (PMID: 27043358) Nat Rev Dis Primers. 2019 Sep 23;5(1):66. (PMID: 31548545) Magn Reson Med Sci. 2023 Oct 1;22(4):469-476. (PMID: 35922924) IEEE Trans Med Imaging. 2008 Jun;27(6):858-65. (PMID: 18541492) Integr Biol (Camb). 2015 Oct;7(10):1120-34. (PMID: 25959051) Neuroimage. 2013 Sep;78:16-32. (PMID: 23587694) Br J Radiol. 2019 May;92(1097):20181032. (PMID: 30835501) Cancer Cell. 2023 Mar 13;41(3):404-420. (PMID: 36800999) Br J Cancer. 2018 Aug;119(4):435-439. (PMID: 30057407) Biopolymers. 2008 Feb;89(2):135-43. (PMID: 17957715) Radiology. 2019 Sep;292(3):520-536. (PMID: 31361209) Radiographics. 2016 May-Jun;36(3):623-39. (PMID: 27082663) Radiology. 2015 Oct;277(1):46-55. (PMID: 25938679) Mol Cancer. 2022 Nov 2;21(1):208. (PMID: 36324128) Neuroimage. 2016 Feb 15;127:422-434. (PMID: 26584864) J Magn Reson Imaging. 2019 Jan;49(1):23-40. (PMID: 30311988) J Magn Reson Imaging. 2020 Jun;51(6):1868-1878. (PMID: 31837076) Int J Cancer. 2021 Sep 1;149(5):1181-1188. (PMID: 34043821) Nat Rev Clin Oncol. 2018 Jun;15(6):366-381. (PMID: 29651130) Lung Cancer. 2018 Apr;118:30-35. (PMID: 29571999) J Oncol. 2020 Apr 21;2020:9050631. (PMID: 32377197) Eur J Radiol. 2020 May;126:108914. (PMID: 32197137) Gynecol Oncol. 2020 Mar;156(3):676-681. (PMID: 31882242) J Magn Reson Imaging. 2002 Aug;16(2):172-8. (PMID: 12203765) Eur Radiol. 2022 Jun;32(6):3744-3754. (PMID: 35076759) Breast Cancer Res. 2019 Sep 4;21(1):102. (PMID: 31484577) Radiology. 2014 Apr;271(1):30-7. (PMID: 24475830) Int J Cancer. 2020 Apr 15;146(8):2296-2304. (PMID: 31901133) Pharmacol Ther. 2014 Feb;141(2):192-208. (PMID: 24134903) Biophys J. 2002 Sep;83(3):1650-60. (PMID: 12202388) Diagnostics (Basel). 2022 Jan 27;12(2):. (PMID: 35204423) J Magn Reson Imaging. 2020 Jul;52(1):70-90. (PMID: 31520518) Front Oncol. 2022 Feb 03;12:817070. (PMID: 35186753) |
| فهرسة مساهمة: | Keywords: Breast; MR Diffusion-weighted Imaging; MR Imaging; Oncology |
| سلسلة جزيئية: | ClinicalTrials.gov NCT05159323 |
| تواريخ الأحداث: | Date Created: 20240614 Date Completed: 20240614 Latest Revision: 20240801 |
| رمز التحديث: | 20240801 |
| مُعرف محوري في PubMed: | PMC11287226 |
| DOI: | 10.1148/rycan.230165 |
| PMID: | 38874529 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2638-616X |
|---|---|
| DOI: | 10.1148/rycan.230165 |