دورية أكاديمية
أعرض في EDS

Microbial communities, antibiotic resistance genes, and virulence factors in urinary infectious stone-associated urinary tract infections.

التفاصيل البيبلوغرافية
العنوان: Microbial communities, antibiotic resistance genes, and virulence factors in urinary infectious stone-associated urinary tract infections.
المؤلفون: Li Z; Center for Translational Medicine Research, Shandong Provincial Third Hospital, Shandong University, Jinan, China., Zhang Z; Urology Department, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, China., Yu P; Urology Department, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, China.; Urology Department, Weihai Municipal Hospital, Shandong University, Weihai, China., Ni Y; Urology Department, Shandong Provincial Third Hospital, Shandong University, Jinan, China. nyl_cabin@163.com.
المصدر: Urolithiasis [Urolithiasis] 2024 Jun 14; Vol. 52 (1), pp. 88. Date of Electronic Publication: 2024 Jun 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101602699 Publication Model: Electronic Cited Medium: Internet ISSN: 2194-7236 (Electronic) Linking ISSN: 21947228 NLM ISO Abbreviation: Urolithiasis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer, [2013]-
مواضيع طبية MeSH: Urinary Tract Infections*/microbiology , Urinary Tract Infections*/drug therapy , Virulence Factors*/genetics, Humans ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Microbiota/drug effects ; Microbiota/genetics ; Drug Resistance, Bacterial/genetics ; Urinary Calculi/microbiology ; Urinary Calculi/genetics ; Female ; Male ; Drug Resistance, Microbial/genetics
مستخلص: Urinary infectious stones are challenging due to bacterial involvement, necessitating a comprehensive understanding of these conditions. Antibiotic-resistant urease-producing bacteria further complicate clinical management. In this study, analysis of urine and stone samples from urinary tract infection (UTI) patients revealed microbial shifts, gene enrichment in stones, and metabolic pathway disparities; antibiotic resistance gene trends were phylum-specific, urease-producing bacteria are at risk of acquiring AMR carried by Enterobacteriaceae under antibiotic, emphasizing potential AMR dissemination between them; Correlations of key pathogenic species in kidney stone and urine microbial communities highlight the need for targeted therapeutic strategies to manage complexities in UTIs; Stones and urine contain a variety of deleterious genes even before antibiotic use, and piperacillin/tazobactam better reduced the abundance of antibiotic resistance genes in stones and urine. The presence of diverse antibiotic resistance and virulence genes underscores challenges in clinical management and emphasizes the need for effective treatment strategies to mitigate risks associated with UTIs and urinary infectious stone formation. Ongoing research is vital for advancing knowledge and developing innovative approaches to address these urological conditions.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة: 202204050772 Shandong Province Medicine and Health Science and Technology Development Program Project; jqrc010 Outstanding Young Talent Project of Shandong Provincial Third Hospital
فهرسة مساهمة: Keywords: Antibiotic resistance gene; Microbiome; Urinary stones; Urinary tract infections; Urine
المشرفين على المادة: 0 (Virulence Factors)
0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20240614 Date Completed: 20240614 Latest Revision: 20240614
رمز التحديث: 20240614
DOI: 10.1007/s00240-024-01588-x
PMID: 38874649
قاعدة البيانات: MEDLINE
الوصف
تدمد:2194-7236
DOI:10.1007/s00240-024-01588-x