دورية أكاديمية
أعرض في EDS

Anshen Shumai Decoction inhibits post-infarction inflammation and myocardial remodeling through suppression of the p38 MAPK/c-FOS/EGR1 pathway.

التفاصيل البيبلوغرافية
العنوان: Anshen Shumai Decoction inhibits post-infarction inflammation and myocardial remodeling through suppression of the p38 MAPK/c-FOS/EGR1 pathway.
المؤلفون: Wang J; Department of Cardiology, Chun'an County Traditional Chinese Medicine Hospital, No. 1 Xin'an West Road, Qiandaohu Town, Chun'an County, Hangzhou, 311700, P. R. China., Ye X; School of Medicine, Ningbo University, Ningbo, 315211, P. R. China., Wang Y; Department of Cardiology, Chun'an County Traditional Chinese Medicine Hospital, No. 1 Xin'an West Road, Qiandaohu Town, Chun'an County, Hangzhou, 311700, P. R. China. 89684349@qq.com.
المصدر: Journal of molecular histology [J Mol Histol] 2024 Aug; Vol. 55 (4), pp. 437-454. Date of Electronic Publication: 2024 Jun 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 101193653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1567-2387 (Electronic) Linking ISSN: 15672379 NLM ISO Abbreviation: J Mol Histol Subsets: MEDLINE
أسماء مطبوعة: Publication: Dordrecht, The Netherlands : Springer Netherlands
Original Publication: Dordrecht, The Netherlands : Kluwer Academic Publishers, 2004-
مواضيع طبية MeSH: Myocardial Infarction*/metabolism , Myocardial Infarction*/drug therapy , Myocardial Infarction*/pathology , Early Growth Response Protein 1*/metabolism , Early Growth Response Protein 1*/genetics , p38 Mitogen-Activated Protein Kinases*/metabolism , Proto-Oncogene Proteins c-fos*/metabolism , Proto-Oncogene Proteins c-fos*/genetics , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/drug effects, Animals ; Rats ; Male ; Apoptosis/drug effects ; Ventricular Remodeling/drug effects ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Rats, Sprague-Dawley ; Fibrosis ; Cell Line ; Signal Transduction/drug effects ; Disease Models, Animal ; MAP Kinase Signaling System/drug effects
مستخلص: Anshen Shumai Decoction (ASSMD) is traditionally employed to manage coronary artery disease arrhythmias. Its protective efficacy against myocardial infarction remains to be elucidated. This investigation employed a rat model of myocardial infarction, achieved through the ligation of the left anterior descending (LAD) coronary artery, followed by a 28-day administration of ASSMD. The study observed the decoction's mitigative impact on myocardial injury, with gene regulation effects discerned through transcriptomic analysis. Furthermore, ASSMD's influence on cardiomyocyte apoptosis and fibrotic protein secretion was assessed using an embryonic rat cardiomyocyte cell line (H9c2) under hypoxic conditions and rat cardiac fibroblasts subjected to normoxic culture conditions with TGF-β. A functional rescue assay involving overexpression of FOS and Early Growth Response Factor 1 (EGR1), combined with inhibition of the p38 Mitogen-activated Protein Kinase (MAPK) pathway, was conducted. Results indicated that ASSMD significantly curtailed cardiomyocyte apoptosis and myocardial fibrosis in infarcted rats, primarily by downregulating FOS and EGR1 gene expression and inhibiting the upstream p38 MAPK pathway. These actions of ASSMD culminated in reduced expression of pro-apoptotic, collagen, and fibrosis-associated proteins, conferring myocardial protection and anti-fibrotic effects on cardiac fibroblasts.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
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معلومات مُعتمدة: No. 2017B58 Hangzhou Health Science and Technology Plan General (Class B) Project; 2021ZA125 Zhejiang Province Traditional Chinese Medicine Modernisation Project
فهرسة مساهمة: Keywords: Anshen Shumai Decoction; Cardiomyocyte apoptosis; Myocardial fibroblasts; Myocardial infarction; p38 MAPK inhibition
المشرفين على المادة: 0 (Early Growth Response Protein 1)
EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
0 (Proto-Oncogene Proteins c-fos)
0 (Egr1 protein, rat)
0 (Drugs, Chinese Herbal)
تواريخ الأحداث: Date Created: 20240614 Date Completed: 20240807 Latest Revision: 20240807
رمز التحديث: 20240808
DOI: 10.1007/s10735-024-10214-4
PMID: 38874870
قاعدة البيانات: MEDLINE
الوصف
تدمد:1567-2387
DOI:10.1007/s10735-024-10214-4