دورية أكاديمية
FATAL ACUTE HEMOLYSIS FOLLOWING TRIAZOLE THERAPY IN AFRICAN PENGUINS ( SPHENISCUS DEMERSUS ).
| العنوان: | FATAL ACUTE HEMOLYSIS FOLLOWING TRIAZOLE THERAPY IN AFRICAN PENGUINS ( SPHENISCUS DEMERSUS ). |
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| المؤلفون: | Patson CN; Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA., Elsmo EJ; Wisconsin Veterinary Diagnostic Laboratory, Madison, WI 53706, USA., Trepanier L; Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA., Garner MM; Northwest ZooPath, Monroe, WA 98272, USA., Murray MJ; Monterey Bay Aquarium, Monterey, CA 93940, USA., Bronson E; Maryland Zoo in Baltimore, Baltimore, MD 21217, USA., Clarke LL; Wisconsin Veterinary Diagnostic Laboratory, Madison, WI 53706, USA., Cox SK; University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37996, USA., Ossiboff RJ; Department of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA., Iredale ME; Department of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA., Miller BM; Department of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA., Waxman L; Florida Aquarium, Tampa, FL 33602, USA., Littman E; Adventure Aquarium, Camden, NJ 08103, USA., Thurber MI; Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA, mary.i.thurber@gmail.com. |
| المصدر: | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians [J Zoo Wildl Med] 2024 Jun; Vol. 55 (2), pp. 479-489. |
| نوع المنشور: | Journal Article; Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association Of Zoo Veterinarians Country of Publication: United States NLM ID: 8915208 Publication Model: Print Cited Medium: Internet ISSN: 1042-7260 (Print) Linking ISSN: 10427260 NLM ISO Abbreviation: J Zoo Wildl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Lawrence Ks : American Association Of Zoo Veterinarians Original Publication: Lawrence, Kan. : The Association, [1989- |
| مواضيع طبية MeSH: | Spheniscidae* , Bird Diseases*/chemically induced , Bird Diseases*/drug therapy , Hemolysis*/drug effects , Antifungal Agents*/adverse effects , Antifungal Agents*/therapeutic use , Antifungal Agents*/administration & dosage , Voriconazole*/adverse effects , Voriconazole*/therapeutic use, Animals ; Itraconazole/adverse effects ; Itraconazole/therapeutic use ; Itraconazole/administration & dosage ; Triazoles/adverse effects ; Triazoles/therapeutic use ; Male ; Female ; Animals, Zoo |
| مستخلص: | Aspergillosis is a major cause of morbidity and mortality in penguins, with triazole antifungal drugs being commonly used for prophylaxis and treatment. This report describes 15 cases of fatal hemolysis associated with liquid itraconazole and voriconazole formulations administered to African penguins ( Spheniscus demersus ) from four institutions. All penguins underwent stressful events (e.g. relocation, induced molt) and were administered commercial liquid itraconazole formulations or compounded voriconazole liquid suspension. Observed clinical signs in affected penguins prior to death included hyporexia, weight loss, lethargy, dyspnea, red-tinged droppings, and obtunded mentation. Intra- and extravascular hemolysis and hemoglobinuric nephrosis were the primary pathologic manifestations on postmortem examination. The concentration-dependent hemolytic potentials of itraconazole, voriconazole, and commercial and compounded vehicle suspensions were evaluated in vitro by exposing chicken whole blood as a surrogate for penguin blood. Hemoglobin content in blood plasma was then measured by spectrophotometry. Neither itraconazole nor voriconazole alone induced hemolysis in vitro. The vehicle ingredients sorbitol and hydromellose induced hemolysis, but not at predicted plasma levels in chicken erythrocytes, suggesting neither the azole antifungals nor their major vehicles alone were likely to contribute to hemolysis in vivo in these penguins. Potential mechanisms of toxicosis include generation of an unmeasured reactive metabolite causing hemolysis, preexisting erythrocyte fragility, or species-specific differences in hemolytic thresholds that were not assessed in the chicken erythrocyte model. More research is needed on the potential for toxicosis of azole antifungal drugs and carrier molecules in this and other avian species. |
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| المشرفين على المادة: | 0 (Antifungal Agents) JFU09I87TR (Voriconazole) 304NUG5GF4 (Itraconazole) 0 (Triazoles) |
| تواريخ الأحداث: | Date Created: 20240614 Date Completed: 20240614 Latest Revision: 20240614 |
| رمز التحديث: | 20240615 |
| DOI: | 10.1638/2023-0073 |
| PMID: | 38875206 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1042-7260 |
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| DOI: | 10.1638/2023-0073 |