دورية أكاديمية
أعرض في EDS

Gut microbiota, inflammatory factors, and scoliosis: A Mendelian randomization study.

التفاصيل البيبلوغرافية
العنوان: Gut microbiota, inflammatory factors, and scoliosis: A Mendelian randomization study.
المؤلفون: Zhao X; Department of Physical Education and Arts, Bengbu Medical College, Bengbu, China.; Graduate School, Adamson University, Manila, Philippines., Liu J; Physical Education Department, Bozhou University, Bozhou, China., Zhang L; Department of Physical Education and Arts, Bengbu Medical College, Bengbu, China., Ma C; Department of Physical Education and Arts, Bengbu Medical College, Bengbu, China., Liu Y; Department of Physical Education and Arts, Bengbu Medical College, Bengbu, China., Wen H; Department of Physical Education and Arts, Bengbu Medical College, Bengbu, China., Li CQ; Department of Physical Education and Arts, Bengbu Medical College, Bengbu, China.
المصدر: Medicine [Medicine (Baltimore)] 2024 Jun 14; Vol. 103 (24), pp. e38561.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
مواضيع طبية MeSH: Mendelian Randomization Analysis* , Scoliosis*/genetics , Gastrointestinal Microbiome*/genetics , Genome-Wide Association Study* , Genetic Predisposition to Disease*, Humans ; Inflammation Mediators/metabolism ; Inflammation Mediators/blood
مستخلص: Several studies have reported a potential association between the gut microbiota (GM) and scoliosis. However, the causal relationship between GM and scoliosis and the role of inflammatory factors (IFs) as mediators remain unclear. This study aimed to analyze the relationship between GM, IFs, and scoliosis. We investigated whether IFs act as mediators in pathways from the GM to scoliosis. Additionally, using reverse Mendelian randomization (MR) analysis, we further investigated the potential impact of genetic predisposition to scoliosis on the GM and IFs. In this study, we searched for publicly available genome-wide association study aggregate data and utilized the MR method to establish bidirectional causal relationships among 211 GM taxa, 91 IFs, and scoliosis. To ensure the reliability of our research findings, we employed 5 MR methods, with the inverse variance weighting approach serving as the primary statistical method, and assessed the robustness of the results through various sensitivity analyses. Additionally, we investigated whether IFs mediate pathways from GM to scoliosis. Three negative causal correlations were observed between the genetic predisposition to GM and scoliosis. Additionally, both positive and negative correlations were found between IFs and scoliosis, with 3 positive and 3 negative correlations observed. IFs do not appear to act as mediators in the pathway from GM to scoliosis. In conclusion, this study demonstrated a causal association between the GM, IFs, and scoliosis, indicating that IFs are not mediators in the pathway from the GM to scoliosis. These findings offer new insights into prevention and treatment strategies for scoliosis.
Competing Interests: The authors have no conflicts of interest to disclose.
(Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
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المشرفين على المادة: 0 (Inflammation Mediators)
تواريخ الأحداث: Date Created: 20240614 Date Completed: 20240614 Latest Revision: 20240618
رمز التحديث: 20240618
مُعرف محوري في PubMed: PMC11175948
DOI: 10.1097/MD.0000000000038561
PMID: 38875409
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-5964
DOI:10.1097/MD.0000000000038561