دورية أكاديمية
Glucose-6-phosphate dehydrogenase and transketolase: Key factors in breast cancer progression and therapy.
| العنوان: | Glucose-6-phosphate dehydrogenase and transketolase: Key factors in breast cancer progression and therapy. |
|---|---|
| المؤلفون: | Zhen X; Department of Physical examination center, China-Japan Union Hospital of Jilin University, 126 Xiantai Blvd, Changchun 130033, People's Republic of China., Zhang M; Department of Orthopaedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Blvd, Changchun 130033, People's Republic of China., Hao S; Department of Pathology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, People's Republic of China. Electronic address: tiedan19951028@163.com., Sun J; Department of Physical examination center, China-Japan Union Hospital of Jilin University, 126 Xiantai Blvd, Changchun 130033, People's Republic of China. Electronic address: sunjing99@jlu.edu.cn. |
| المصدر: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Jul; Vol. 176, pp. 116935. Date of Electronic Publication: 2024 Jun 14. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Paris : Editions Scientifiques Elsevier Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982- |
| مواضيع طبية MeSH: | Transketolase*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/enzymology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Glucosephosphate Dehydrogenase*/metabolism , Disease Progression* , Pentose Phosphate Pathway*/drug effects, Humans ; Female ; Animals |
| مستخلص: | Breast cancer is one of the most common malignant tumors in women and is a serious threat to women's health. The pentose phosphate pathway (PPP) is a mode of oxidative breakdown of glucose that can be divided into oxidative (oxPPP) and non-oxidative (non-oxPPP) stages and is necessary for cell and body survival. However, abnormal activation of PPP often leads to proliferation, migration, invasion, and chemotherapy resistance in breast cancer. Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme in PPP oxidation. Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) produced by G6PD is the raw material for cholesterol and lipid synthesis and can resist the production of oxygen species (ROS) and reduce oxidative stress damage to tumor cells. Transketolase (TKT) is a key enzyme in non-oxPPP. Ribose 5-phosphate (R5P), produced by TKT, is a raw material for DNA and RNA synthesis, and is essential for tumor cell proliferation and DNA damage repair. In this review, we describe the role and specific mechanism of the PPP and the two most important enzymes of the PPP, G6PD and TKT, in the malignant progression of breast cancer, providing strategies for future clinical treatment of breast cancer and a theoretical basis for breast cancer research. Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest. (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Breast cancer; G6PD; Metabolism; TKT |
| المشرفين على المادة: | EC 2.2.1.1 (Transketolase) EC 1.1.1.49 (Glucosephosphate Dehydrogenase) |
| تواريخ الأحداث: | Date Created: 20240614 Date Completed: 20240619 Latest Revision: 20240625 |
| رمز التحديث: | 20240626 |
| DOI: | 10.1016/j.biopha.2024.116935 |
| PMID: | 38876050 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1950-6007 |
|---|---|
| DOI: | 10.1016/j.biopha.2024.116935 |