دورية أكاديمية
Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia.
| العنوان: | Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia. |
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| المؤلفون: | Ong KOK; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Mok MMH; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Niibori-Nambu A; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Du L; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Yanagida M; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore., Wang CQ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore., Bahirvani AG; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Chin DWL; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Koh CP; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Ng KP; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Yamashita N; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore., Jacob B; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore., Yokomizo T; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; International Research Center for Medical Sciences, Kumamoto University, Japan., Takizawa H; International Research Center for Medical Sciences, Kumamoto University, Japan., Matsumura T; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Suda T; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Lau JA; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; Translational Centre for Development and Research, National University Health System, Singapore, Singapore., Mori S; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Yang H; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Iwasaki M; Institute of Laboratory Animals, Tokyo Women's Medical University, Japan., Minami T; Center for Animal Resources and Development, Kumamoto University, Japan., Asou N; International Medical Center, Saitama Medical University, Japan., Sun QY; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Ding LW; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Koeffler HP; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Tenen DG; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Shimizu R; School of Medicine, Tohoku University, Japan., Yamamoto M; School of Medicine, Tohoku University, Japan., Ito Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore., Kham SKY; Department of Paediatrics, National University of Singapore, Singapore, Singapore., Yeoh AE; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; Department of Paediatrics, National University of Singapore, Singapore, Singapore. Electronic address: allen_yeoh@nuhs.edu.sg., Chng WJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: wee_joo_chng@nuhs.edu.sg., Osato M; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore; International Research Center for Medical Sciences, Kumamoto University, Japan; Department of Paediatrics, National University of Singapore, Singapore, Singapore. Electronic address: motokuma@kumamoto-u.ac.jp. |
| المصدر: | Experimental hematology [Exp Hematol] 2024 Jun 13, pp. 104255. Date of Electronic Publication: 2024 Jun 13. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Inc Country of Publication: Netherlands NLM ID: 0402313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2399 (Electronic) Linking ISSN: 0301472X NLM ISO Abbreviation: Exp Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : Amsterdam : Elsevier Science Inc. Original Publication: Copenhagen, Munksgaard. |
| مستخلص: | The genetic lesions that drive acute megakaryoblastic leukemia (AMKL) have not been fully elucidated. To search for genetic alterations in AMKL, we performed targeted deep sequencing in 34 AMKL patient samples and 8 AMKL cell lines and detected frequent genetic mutations in the NOTCH pathway in addition to previously reported alterations in GATA-1 and the JAK-STAT pathway. Pharmacological and genetic NOTCH activation, but not inhibition, significantly suppressed AMKL cell proliferation in both in vitro and in vivo assays employing a patient-derived xenograft model. These results suggest that NOTCH inactivation underlies AMKL leukemogenesis. and NOTCH activation holds the potential for therapeutic application in AMKL. Competing Interests: Conflicts of Interest Disclosure The authors have nothing to disclose. (Copyright © 2024 International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20240614 Latest Revision: 20240630 |
| رمز التحديث: | 20240701 |
| DOI: | 10.1016/j.exphem.2024.104255 |
| PMID: | 38876252 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-2399 |
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| DOI: | 10.1016/j.exphem.2024.104255 |