دورية أكاديمية
أعرض في EDS

Polyelectrolyte complexes of chitosan and hyaluronic acid or carboxymethylpullulan and their aminoguaiacol derivatives with biological activities as potential drug delivery systems.

التفاصيل البيبلوغرافية
العنوان: Polyelectrolyte complexes of chitosan and hyaluronic acid or carboxymethylpullulan and their aminoguaiacol derivatives with biological activities as potential drug delivery systems.
المؤلفون: Dulong V; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, UMR 6270 PBS, 76000 Rouen, France. Electronic address: virginie.dulong@univ-rouen.fr., Thebault P; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, UMR 6270 PBS, 76000 Rouen, France., Karakasyan C; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, UMR 6270 PBS, 76000 Rouen, France., Picton L; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, UMR 6270 PBS, 76000 Rouen, France., le Cerf D; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, UMR 6270 PBS, 76000 Rouen, France.
المصدر: Carbohydrate polymers [Carbohydr Polym] 2024 Oct 01; Vol. 341, pp. 122330. Date of Electronic Publication: 2024 May 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE
أسماء مطبوعة: Publication: <1992-> : Barking : Elsevier Applied Science Publishers
Original Publication: London [Eng.] : Applied Science Publishers, c1981-
مواضيع طبية MeSH: Hyaluronic Acid*/chemistry , Chitosan*/chemistry , Chitosan*/analogs & derivatives , Curcumin*/chemistry , Curcumin*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology, Antioxidants/chemistry ; Antioxidants/pharmacology ; Guaiacol/chemistry ; Guaiacol/analogs & derivatives ; Guaiacol/pharmacology ; Diclofenac/chemistry ; Diclofenac/pharmacology ; Drug Carriers/chemistry ; Polyelectrolytes/chemistry ; Drug Delivery Systems/methods ; Nanogels/chemistry ; Glucans/chemistry ; Escherichia coli/drug effects ; Drug Liberation
مستخلص: Polyelectrolyte complexes (PECs) were elaborated from chitosan as cationic polymer and carboxy-methylpullulan (CMP), hyaluronic acid (HA) and their derivatives grafted with aminoguaiacol (G) with different degrees of substitution (DS GA ) with the aim of obtaining nanogels for drug delivery. For each couple of polysaccharides, the charge ratios giving the smaller size with the lower PDI were selected to produce PECs. CMP_CHIT and CMP-G_CHIT PECs had smaller sizes (220-280 nm) than HA_CHIT and HA-G_CHIT PECs (280-390 nm). PECs were stable at 4 °C during 28 days at pH 5. In phosphate buffer saline (PBS) at pH 7.4, at 4 °C, a better stability of PECs based on CMP-G derivatives was observed. The hydrophobic associations between aminoguaiacol groups (highlighted by measurements of pyrene fluorescence) led to a better PECs' stabilization in PBS. The PECs' antioxidant and antibacterial activities were demonstrated and related to the DS GA . Diclofenac and curcumin were used as drug models: their loading reached 260 and 53 μg/mg PEC, respectively. The release of diclofenac in PBS at 37 °C followed a quasi-Fickian diffusion mechanism with release constant between 0.88 and 1.04 h -1 . The curcumin release followed a slow linear increase in PBS/EtOH (60/40 V/V) with an effect of DS GA .
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Antibacterial; Antioxidant; Drug delivery systems; Guaiacol; Polysaccharide
المشرفين على المادة: 9004-61-9 (Hyaluronic Acid)
9012-76-4 (Chitosan)
IT942ZTH98 (Curcumin)
0 (Anti-Bacterial Agents)
0 (Antioxidants)
6JKA7MAH9C (Guaiacol)
144O8QL0L1 (Diclofenac)
0 (Drug Carriers)
0 (Polyelectrolytes)
0 (Nanogels)
0 (Glucans)
تواريخ الأحداث: Date Created: 20240614 Date Completed: 20240614 Latest Revision: 20240614
رمز التحديث: 20240615
DOI: 10.1016/j.carbpol.2024.122330
PMID: 38876726
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1344
DOI:10.1016/j.carbpol.2024.122330