دورية أكاديمية
Papillary renal neoplasm with reverse polarity has low frequency of alterations in chromosomes 7, 17, and Y.
| العنوان: | Papillary renal neoplasm with reverse polarity has low frequency of alterations in chromosomes 7, 17, and Y. |
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| المؤلفون: | Kiyozawa D; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Iwasaki T; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan., Takamatsu D; Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Kohashi K; Department of Pathology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Miyamoto T; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan., Fukuchi G; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.; Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Eto M; Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Yamashita M; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Oda Y; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. oda.yoshinao.389@m.kyushu-u.ac.jp. |
| المصدر: | Virchows Archiv : an international journal of pathology [Virchows Arch] 2024 Aug; Vol. 485 (2), pp. 299-306. Date of Electronic Publication: 2024 Jun 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 9423843 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2307 (Electronic) Linking ISSN: 09456317 NLM ISO Abbreviation: Virchows Arch Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer International, c1994- |
| مواضيع طبية MeSH: | Kidney Neoplasms*/genetics , Kidney Neoplasms*/pathology , In Situ Hybridization, Fluorescence* , Chromosomes, Human, Pair 7*/genetics , Chromosomes, Human, Pair 17*/genetics , Chromosomes, Human, Y*/genetics, Humans ; Male ; Middle Aged ; Female ; Aged ; Adult ; Comparative Genomic Hybridization ; Immunohistochemistry ; Chromosome Aberrations ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; DNA Copy Number Variations |
| مستخلص: | In papillary renal neoplasm with reverse polarity (PRNRP), the status of chromosomal copy number alterations, especially chromosomes 7/17 gain and chromosome Y loss, has remained controversial. In the literatures, there is a discrepancy among the results of chromosomal alteration in PRNRP depending on the analytical methods. Here, we comprehensively analyzed the status of chromosomal abnormalities in PRNRP. Nineteen PRNRP cases were analyzed by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC), five of which were additionally subjected to array-based comparative genomic hybridization (aCGH) analysis. Fifteen cases of PRCC were used as controls. From the aCGH results, no genome copy number abnormalities were found in the five PRNRP cases. By FISH, numbers of nuclei with abnormal chromosomal signals in PRNRP (centromere 7 gain: 11-21% of nuclei, centromere 17 gain: 11% of nuclei, centromere Y loss: 14-31% of nuclei) were similar to those in non-neoplastic tubular cells (centromere 7 gain: 11-15% of nuclei, centromere 17 gain: 12-15% of nuclei, centromere Y loss: 13-45% of nuclei). c-MET immunohistochemical overexpression, a substitute marker for chromosome 7 trisomy, was observed in 0 of 19 PRNRP cases, consistent with the analyses by aCGH and NGS regarding chromosome 7 gain. Taken together, the frequency of chromosomal alterations in PRNRP is similar to that in non-neoplastic tubular cells, and lower than that in PRCC. Our data suggest that PRNRP has a different tumorigenesis and is a distinct entity from PRCC. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| معلومات مُعتمدة: | 23K14479 Japan Society for the Promotion of Science London |
| فهرسة مساهمة: | Keywords: Array-CGH; Chromosome; Fluorescence in situ hybridization; MET; Papillary renal neoplasm with reverse polarity |
| تواريخ الأحداث: | Date Created: 20240614 Date Completed: 20240816 Latest Revision: 20240816 |
| رمز التحديث: | 20240816 |
| DOI: | 10.1007/s00428-024-03840-6 |
| PMID: | 38877360 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-2307 |
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| DOI: | 10.1007/s00428-024-03840-6 |