دورية أكاديمية
Comparison of postoperative topical interferon-α2b versus intraoperative mitomycin C for pterygium recurrence prevention: a randomized clinical trial.
| العنوان: | Comparison of postoperative topical interferon-α2b versus intraoperative mitomycin C for pterygium recurrence prevention: a randomized clinical trial. |
|---|---|
| المؤلفون: | Akbari M; Eye Research Center, Department of Eye, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Science, Rasht, Iran. mitra.akbari20@gmail.com., Moghadam RS; Eye Research Center, Department of Eye, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Science, Rasht, Iran., Leili EK; Eye Research Center, Department of Eye, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Science, Rasht, Iran., Medghalchi A; Eye Research Center, Department of Eye, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Science, Rasht, Iran., Mahmoudi H; Eye Research Center, Department of Eye, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Science, Rasht, Iran. |
| المصدر: | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2024 Jun 15. Date of Electronic Publication: 2024 Jun 15. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 8205248 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-702X (Electronic) Linking ISSN: 0721832X NLM ISO Abbreviation: Graefes Arch Clin Exp Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer-Verlag, c1982- |
| مستخلص: | Purpose: To evaluate the effect of postoperative interferon-alpha 2b (IFN-α2b) ophthalmic drops versus intraoperative mitomycin-c (MMC) on preventing pterygium recurrence. Methods: This prospective randomized clinical trial was conducted on patients who were candidates for pterygium surgery. A total of 75 patients were included in the study from December 2021 to December 2022, of which 64 patients (one eye each) were examined and analyzed based on the inclusion criteria. Then the patients were randomly assigned to control groups, intra-operative MMC (32 patients) and the intervention group, IFN-α2b drops after the operation (32 patients). All patients underwent pterygium surgery using the rotational conjunctival flap method. Results: In terms of pterygium grading, 8 (12.5%), 25 (39.06%), and 31 (48.44%) eyes were in grades 1, 2, and 3, respectively. The average size of the pterygium was 3.6 ± 0.7 mm. The grade and size of pterygium had the same distribution in the two groups. There was no statistically significant difference between the two groups in the level of post-operative clinical inflammation. The present study showed no significant difference in complications between the two groups (p = 0.999). The recurrence rate in the control group was 9.4% (3 eyes), and 0% (no recurrence) in the intervention group (p = 0.119). Conclusions: interferon-alpha 2b group did not show a statistically significant difference in preventing pterygium recurrence compared to the mitomycin C group. The post-surgery administration of IFN-α 2b drops can effectively prevent pterygium recurrence with a comparable and even more compelling effect than MMC during surgery. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| References: | Fonseca EC, Rocha EM, Arruda GV (2018) Comparison among adjuvant treatments for primary pterygium: a network meta-analysis. Br J Ophthalmol 102(6):748–756. (PMID: 2914676110.1136/bjophthalmol-2017-310288) Srinivasan S, Dollin M, McAllum P, Berger Y, Rootman DS, Slomovic AR (2009) Fibrin glue versus sutures for attaching the conjunctival autograft in pterygium surgery: a prospective observer masked clinical trial. Br J Ophthalmol 93(2):215–218. (PMID: 1901993010.1136/bjo.2008.145516) Luthra R, Nemesure BB, Wu SY, Xie SH, Leske MC, Barbados Eye Studies G (2001) Frequency and risk factors for pterygium in the Barbados Eye Study. Arch Ophthalmol 119(12):1827–1832. (PMID: 1173579510.1001/archopht.119.12.1827) Zhang Q, Bao N, Liang K, Tao L (2018) Adjuvant use of Cyclosporine A in the treatment of primary pterygium: a systematic review and Meta-analysis. Cornea 37(8):1000–1007. (PMID: 2960136510.1097/ICO.0000000000001542) Cao D, Ng TK, Yip YWY et al (2018) p53 inhibition by MDM2 in human pterygium. Exp Eye Res 175:142–147. (PMID: 2993288210.1016/j.exer.2018.06.021) Tsai YY, Chang KC, Lin CL et al (2005) p53 expression in pterygium by immunohistochemical analysis: a series report of 127 cases and review of the literature. Cornea 24(5):583–586. (PMID: 1596816510.1097/01.ico.0000154404.86462.35) Cao D, Chu WK, Ng TK et al (2018) Cellular Proliferation and Migration of Human Pterygium cells: Mitomycin Versus small-molecule inhibitors. Cornea 37(6):760–766. (PMID: 2959576110.1097/ICO.0000000000001569) Todani A, Melki SA (2009) Pterygium: current concepts in pathogenesis and treatment. Int Ophthalmol Clin 49(1):21–30. (PMID: 1912506110.1097/IIO.0b013e3181924f62) Young AL, Ho M, Jhanji V, Cheng LL (2013) Ten-year results of a randomized controlled trial comparing 0.02% mitomycin C and limbal conjunctival autograft in pterygium surgery. Ophthalmology 120(12):2390–2395. (PMID: 2387030210.1016/j.ophtha.2013.05.033) Tsim NC, Young AL, Jhanji V, Ho M, Cheng LL (2015) Combined conjunctival rotational autograft with 0.02% mitomycin C in primary pterygium surgery: a long-term follow-up study. Br J Ophthalmol 99(10):1396–1400. (PMID: 2583760610.1136/bjophthalmol-2014-305817) Ali AM, Thariat J, Bensadoun RJ et al (2011) The role of radiotherapy in the treatment of pterygium: a review of the literature including more than 6000 treated lesions. Cancer Radiother 15(2):140–147. (PMID: 2067445010.1016/j.canrad.2010.03.020) Kaufman SC, Jacobs DS, Lee WB, Deng SX, Rosenblatt MI, Shtein RM (2013) Options and adjuvants in surgery for pterygium: a report by the American Academy of Ophthalmology. Ophthalmology 120(1):201–208. (PMID: 2306264710.1016/j.ophtha.2012.06.066) Salustiano Correa ESR, de Pereira Avila M, Rassi AR, Ximenes L, da Silva DS Jr., de Paula AC (2013) Intra-operative use of 5-Fluorouracil in pterygium surgery: a comparative study. Semin Ophthalmol 28(1):34–36. (PMID: 10.3109/08820538.2012.730101) Fallah MR, Khosravi K, Hashemian MN, Beheshtnezhad AH, Rajabi MT, Gohari M (2010) Efficacy of topical bevacizumab for inhibiting growth of impending recurrent pterygium. Curr Eye Res 35(1):17–22. (PMID: 2002125010.3109/02713680903395273) Sun Y, Zhang B, Jia X, Ling S, Deng J (2018) Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials. J Ophthalmol 2018:4598173. Hu Q, Qiao Y, Nie X, Cheng X, Ma Y (2014) Bevacizumab in the treatment of pterygium: a meta-analysis. Cornea 33(2):154–160. (PMID: 2432633310.1097/ICO.0000000000000037) Cho CH, Lee SB (2015) Biodegradable collagen matrix (Ologen) implant and conjunctival autograft for scleral necrosis after pterygium excision: two case reports. BMC Ophthalmol 15:140. (PMID: 26499993461933110.1186/s12886-015-0130-z) Lam DS, Wong AK, Fan DS, Chew S, Kwok PS, Tso MO (1998) Intraoperative mitomycin C to prevent recurrence of pterygium after excision: a 30-month follow-up study. Ophthalmology 105(5):901–904. (PMID: 959339510.1016/S0161-6420(98)95034-5) Kaliki S, Singh S, Iram S, Tripuraneni D (2016) Recombinant interferon alpha 2b for ocular surface squamous neoplasia: an efficient and cost-effective treatment modality in Asian Indian patients. Indian J Ophthalmol 64(10):702–709. (PMID: 27905329516890810.4103/0301-4738.195010) Kim HJ, Shields CL, Shah SU, Kaliki S, Lally SE (2012) Giant ocular surface squamous neoplasia managed with interferon alpha-2b as immunotherapy or immunoreduction. Ophthalmology 119(5):938–944. (PMID: 2236131510.1016/j.ophtha.2011.11.035) Kusumesh R, Ambastha A, Kumar S, Sinha BP, Imam N (2017) Retrospective comparative study of topical Interferon alpha2b Versus Mitomycin C for primary ocular surface squamous neoplasia. Cornea 36(3):327–331. (PMID: 2807968810.1097/ICO.0000000000001116) Wang W, Zhang J, Huang Y, Huang J, Jiang J (2011) Clinical study on interferon treatment of early scarring in filtering bleb. Eye Sci 26(4):197–200. (PMID: 22187302) Yin M, Li H, Zhang Y, Dai H, Luo F, Pan Z (2019) Interferon Alpha-2b Eye drops prevent recurrence of Pterygium after the Bare Sclera technique: a Single-Center, sequential, and controlled study. Cornea 38(10):1239–1244. (PMID: 31299663675014610.1097/ICO.0000000000001995) Tan DT, Chee SP, Dear KB, Lim AS (1997) Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision. Arch Ophthalmol 115(10):1235–1240. (PMID: 933866610.1001/archopht.1997.01100160405001) Safi H, Kheirkhah A, Mahbod M, Molaei S, Hashemi H, Jabbarvand M (2016) Correlations between histopathologic changes and clinical features in Pterygia. J Ophthalmic Vis Res 11(2):153–158. (PMID: 27413494492656110.4103/2008-322X.183917) Prabhasawat P, Barton K, Burkett G, Tseng SC (1997) Comparison of conjunctival autografts, amniotic membrane grafts, and primary closure for pterygium excision. Ophthalmology 104(6):974–985. (PMID: 918643910.1016/S0161-6420(97)30197-3) Nuzzi R, Tridico F (2018) How to minimize pterygium recurrence rates: clinical perspectives. Clin Ophthalmol 12:2347–2362. (PMID: 30538417625144010.2147/OPTH.S186543) Meneghim R, Satto LH, Natsuaki KL et al (2019) Topical cyclosporine a 0.05% before and after surgery to prevent pterygium recurrence. Arq Bras Oftalmol 82(5):372–376. (PMID: 3127156910.5935/0004-2749.20190075) Young AL, Tam PM, Leung GY, Cheng LL, Lam PT, Lam DS (2009) Prospective study on the safety and efficacy of combined conjunctival rotational autograft with intraoperative 0.02% mitomycin C in primary pterygium excision. Cornea 28(2):166–169. (PMID: 1915855910.1097/ICO.0b013e318187544d) Bekibele CO, Sarimiye TF, Ogundipe A, Olaniyan S (2016) 5-Fluorouracil vs avastin as adjunct to conjunctival autograft in the surgical treatment of pterygium. Eye (Lond) 30(4):515–521. (PMID: 2698758910.1038/eye.2016.29) Esquenazi S (2005) Treatment of early pterygium recurrence with topical administration of interferon alpha-2b. Can J Ophthalmol 40(2):185–187. (PMID: 1604953310.1016/S0008-4182(05)80031-6) Wang XY, Crowston JG, White AJ, Zoellner H, Healey PR (2014) Interferon-alpha and interferon-gamma modulate Fas-mediated apoptosis in mitomycin-C-resistant human Tenon’s fibroblasts. Clin Exp Ophthalmol 42(6):529–538. (PMID: 2422457110.1111/ceo.12268) Di Girolamo N, Wakefield D, Coroneo MT (2006) UVB-mediated induction of cytokines and growth factors in pterygium epithelial cells involves cell surface receptors and intracellular signaling. Invest Ophthalmol Vis Sci 47(6):2430–2437. (PMID: 1672345310.1167/iovs.05-1130) Zloto O, Rosen N, Leshno A, Rosner M (2017) Very long term success of pterygium surgery with conjunctival graft. Cont Lens Anterior Eye 40(4):267–269. (PMID: 2852225110.1016/j.clae.2017.05.004) Li W, Lou Y, Wang B (2021) Recurrence rate with inferior conjunctival autograft transplantation compared with superior conjunctival autograft transplantation in pterygium surgery: a meta-analysis. BMC Ophthalmol 21(1):131. (PMID: 33750344794194210.1186/s12886-021-01889-4) Nuhoglu F, Turna F, Uyar M, Ozdemir FE, Eltutar K (2013) Is there a relation between histopathologic characteristics of pterygium and recurrence rates? Eur J Ophthalmol 23(3):303–308. (PMID: 2333531510.5301/ejo.5000231) Huang Y, He H, Sheha H, Tseng SC (2013) Ocular demodicosis as a risk factor of pterygium recurrence. Ophthalmology 120(7):1341–1347. (PMID: 2366447110.1016/j.ophtha.2013.01.001) Ghiasian L, Samavat B, Hadi Y, Arbab M, Abolfathzadeh N (2021) Recurrent pterygium: a review. J Curr Ophthalmol 33(4):367–378. (PMID: 3512818110.4103/joco.joco_153_20) Garcia Tirado A, Boto de Los Bueis A, Rivas Jara L (2019) Ocular surface changes in recurrent pterygium cases post-operatively treated with 5-fluorouracil subconjunctival injections. Eur J Ophthalmol 29(1):9–14. (PMID: 2958010210.1177/1120672118757428) Aidenloo NS, Motarjemizadeh Q, Heidarpanah M (2018) Risk factors for pterygium recurrence after limbal-conjunctival autografting: a retrospective, single-centre investigation. Jpn J Ophthalmol 62(3):349–356. (PMID: 2954946210.1007/s10384-018-0582-9) Kucukerdonmez C, Karalezli A, Akova YA, Borazan M (2010) Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial. Eye (Lond) 24(4):558–566. (PMID: 1949845010.1038/eye.2009.136) Olusanya BA, Ogun OA, Bekibele CO et al (2014) Risk factors for pterygium recurrence after surgical excision with combined conjunctival autograft (CAG) and intraoperative antimetabolite use. Afr J Med Med Sci 43(1):35–40. (PMID: 25335376) Rosen R (2018) Amniotic membrane grafts to reduce Pterygium recurrence. Cornea 37(2):189–193. (PMID: 2897641510.1097/ICO.0000000000001407) Ono T, Mori Y, Nejima R, Tokunaga T, Miyata K, Amano S (2016) Long-term follow-up of transplantation of preserved limbal allograft and amniotic membrane for recurrent pterygium. Graefes Arch Clin Exp Ophthalmol 254(12):2425–2430. (PMID: 2756578410.1007/s00417-016-3483-y) Liu J, Sheha H, Tseng SC (2010) Pathogenic role of Demodex mites in blepharitis. Curr Opin Allergy Clin Immunol 10(5):505–510. (PMID: 20689407294681810.1097/ACI.0b013e32833df9f4) Varssano D, Shalev H, Lazar M, Fischer N (2013) Pterygium excision with conjunctival autograft: true survival rate statistics. Cornea 32(9):1243–1250. (PMID: 2359477110.1097/ICO.0b013e31828ce09c) Han SB, Jeon HS, Kim M et al (2016) Risk factors for recurrence after pterygium surgery: an image analysis study. Cornea 35(8):1097–1103. (PMID: 2710065810.1097/ICO.0000000000000853) Sati A, Shankar S, Jha A, Kalra D, Mishra S, Gurunadh VS (2014) Comparison of efficacy of three surgical methods of conjunctival autograft fixation in the treatment of pterygium. Int Ophthalmol 34(6):1233–1239. (PMID: 2537405210.1007/s10792-014-0013-y) Kim KW, Park SH, Kim JC (2016) Fibroblast biology in pterygia. Exp Eye Res 142:32–39. (PMID: 2667540110.1016/j.exer.2015.01.010) Anguria P, Ntuli S, Carmichael T (2014) Young patient’s age determines pterygium recurrence after surgery. Afr Health Sci 14(1):72–76. (PMID: 26060460444908210.4314/ahs.v14i1.11) |
| معلومات مُعتمدة: | 1 United States CX CSRD VA |
| فهرسة مساهمة: | Keywords: Interferon alpha-2b; Mitomycin-C; Pterygium; Pterygium recurrence |
| تواريخ الأحداث: | Date Created: 20240615 Latest Revision: 20240615 |
| رمز التحديث: | 20240616 |
| DOI: | 10.1007/s00417-024-06548-0 |
| PMID: | 38878067 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1435-702X |
|---|---|
| DOI: | 10.1007/s00417-024-06548-0 |