دورية أكاديمية
Minocycline Abrogates Individual Differences in Nerve Injury-Evoked Affective Disturbances in Male Rats and Prevents Associated Supraspinal Neuroinflammation.
| العنوان: | Minocycline Abrogates Individual Differences in Nerve Injury-Evoked Affective Disturbances in Male Rats and Prevents Associated Supraspinal Neuroinflammation. |
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| المؤلفون: | O'Brien JA; Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Austin PJ; Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. paul.austin@sydney.edu.au. |
| المصدر: | Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2024 Jun 15; Vol. 19 (1), pp. 30. Date of Electronic Publication: 2024 Jun 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Springer Science + Business Media, c2006- |
| مواضيع طبية MeSH: | Minocycline*/pharmacology , Neuroinflammatory Diseases*/drug therapy, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Neuralgia/drug therapy ; Neuralgia/metabolism ; Neuralgia/prevention & control ; Hyperalgesia/drug therapy ; Hyperalgesia/prevention & control ; Individuality ; Mood Disorders/drug therapy ; Mood Disorders/etiology ; Peripheral Nerve Injuries/complications |
| مستخلص: | Chronic neuropathic pain precipitates a complex range of affective and behavioural disturbances that differ markedly between individuals. While the reasons for differences in pain-related disability are not well understood, supraspinal neuroimmune interactions are implicated. Minocycline has antidepressant effects in humans and attenuates affective disturbances in rodent models of pain, and acts by reducing neuroinflammation in both the spinal cord and brain. Previous studies, however, tend not to investigate how minocycline modulates individual affective responses to nerve injury, or rely on non-naturalistic behavioural paradigms that fail to capture the complexity of rodent behaviour. We investigated the development and resolution of pain-related affective disturbances in nerve-injured male rats by measuring multiple spontaneous ethological endpoints on a longitudinal naturalistic foraging paradigm, and the effect of chronic oral minocycline administration on these changes. Disrupted foraging behaviours appeared in 22% of nerve-injured rats - termed 'affected' rats - and were present at day 14 but partially resolved by day 21 post-injury. Minocycline completely prevented the emergence of an affected subgroup while only partly attenuating mechanical allodynia, dissociating the relationship between pain and affect. This was associated with a lasting downregulation of ΔFosB expression in ventral hippocampal neurons at day 21 post-injury. Markers of microglia-mediated neuroinflammation were not present by day 21, however proinflammatory microglial polarisation was apparent in the medial prefrontal cortex of affected rats and not in CCI minocycline rats. Individual differences in affective disturbances following nerve injury are therefore temporally related to altered microglial morphology and hippocampal neuronal activation, and are abrogated by minocycline. (© 2024. The Author(s).) |
| References: | Cereb Cortex. 2012 Jun;22(6):1442-54. (PMID: 21878486) Pain. 1999 Apr;80(3):483-491. (PMID: 10342410) Sci Rep. 2017 Oct 16;7(1):13211. (PMID: 29038483) Front Cell Neurosci. 2019 Oct 25;13:472. (PMID: 31708746) J Pain Res. 2021 Jan 26;14:139-145. (PMID: 33536779) Neurosci Lett. 2001 Nov 23;315(1-2):61-4. (PMID: 11711215) Brain Behav Immun. 2011 Oct;25(7):1322-32. (PMID: 21496480) Front Behav Neurosci. 2022 Jan 05;15:811987. (PMID: 35069144) Nat Commun. 2022 Feb 11;13(1):843. (PMID: 35149686) Psychiatr Q. 2020 Jun;91(2):451-461. (PMID: 31965454) Pain Res Manag. 2020 Jun 16;2020:7408508. (PMID: 32617124) JAMA. 2010 Apr 7;303(13):1295-302. (PMID: 20371789) Pharmacol Rev. 2013 Dec 11;66(1):80-101. (PMID: 24335193) Nat Neurosci. 2015 Aug;18(8):1081-3. (PMID: 26120961) eNeuro. 2018 Aug 3;5(4):. (PMID: 30079375) Spine (Phila Pa 1976). 2002 Mar 1;27(5):E109-20. (PMID: 11880847) Eur J Pain. 2022 Jul;26(6):1322-1332. (PMID: 35437876) Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9685-90. (PMID: 16769901) Ann Surg. 2001 Jan;233(1):1-7. (PMID: 11141218) Pain. 2022 Nov 1;163(11):e1129-e1144. (PMID: 35384869) Curr Opin Neurobiol. 2010 Aug;20(4):474-80. (PMID: 20817512) Neuroscience. 2019 Sep 15;416:147-167. (PMID: 31401182) Eur J Neurosci. 2003 May;17(9):1907-20. (PMID: 12752790) Clin Rheumatol. 2015 Mar;34(3):555-61. (PMID: 24407907) Pain. 1979 Jun;6(3):253-264. (PMID: 460933) Clin J Pain. 2022 Oct 01;38(10):595-600. (PMID: 36108108) Neurosci Lett. 2004 May 6;361(1-3):188-91. (PMID: 15135925) J Neurochem. 2004 Dec;91(5):1219-30. (PMID: 15569265) Behav Neurol. 2022 Jul 16;2022:9770047. (PMID: 35880039) J Peripher Nerv Syst. 2022 Dec;27(4):291-301. (PMID: 36168866) Glia. 2022 Apr;70(4):675-696. (PMID: 35050555) Pain. 2024 Apr 1;165(4):848-865. (PMID: 37943063) Transl Psychiatry. 2019 Sep 13;9(1):223. (PMID: 31519869) Sci Transl Med. 2022 May 11;14(644):eabj9954. (PMID: 35544595) J Affect Disord. 2018 Feb;227:219-225. (PMID: 29102836) Lancet. 2006 May 13;367(9522):1618-25. (PMID: 16698416) Front Neurosci. 2017 Apr 18;11:209. (PMID: 28458629) J Neuroimmunol. 2010 Dec 15;229(1-2):26-50. (PMID: 20870295) J Immunol. 2005 Feb 15;174(4):2288-96. (PMID: 15699164) Neurosci Res. 2011 Jul;70(3):305-12. (PMID: 21515316) Eur J Pain. 2012 Nov;16(10):1426-36. (PMID: 22451419) Philos Trans R Soc Lond B Biol Sci. 2010 Dec 27;365(1560):4021-8. (PMID: 21078654) Nat Methods. 2012 Jun 28;9(7):676-82. (PMID: 22743772) Brain Sci. 2022 Sep 24;12(10):. (PMID: 36291221) Brain Behav Immun. 2008 Jul;22(5):662-7. (PMID: 18395410) Sci Rep. 2017 Jun 9;7(1):3124. (PMID: 28600519) Brain Behav Immun. 2020 Aug;88:482-496. (PMID: 32283287) Cell Death Dis. 2013 Mar 07;4:e525. (PMID: 23470532) Eur J Pain. 2022 Feb;26(2):370-389. (PMID: 34592017) J Neuroinflammation. 2022 Dec 8;19(1):292. (PMID: 36482444) Genes Brain Behav. 2019 Jul;18(6):e12542. (PMID: 30488664) J Neuroimmunol. 2014 Dec 15;277(1-2):57-66. (PMID: 25304927) Behav Brain Res. 2017 Jun 1;327:1-10. (PMID: 28286285) Neurosci Lett. 2021 Jan 1;740:135423. (PMID: 33069811) Brain Behav Immun. 2014 Nov;42:147-56. (PMID: 24994592) Neuroscience. 2010 Apr 14;166(4):1167-84. (PMID: 20109535) J Rehabil Med. 2017 Jun 28;49(6):489-496. (PMID: 28597908) J Neurosci. 2021 May 12;41(19):4349-4365. (PMID: 33846230) Physiol Behav. 1978 May;20(5):597-605. (PMID: 684094) J Neurochem. 2006 Jan;96(2):314-23. (PMID: 16336636) J Pharmacol Exp Ther. 2003 Aug;306(2):624-30. (PMID: 12734393) Am J Pathol. 2007 Oct;171(4):1199-214. (PMID: 17717149) Neuron. 2023 Sep 20;111(18):2811-2830.e8. (PMID: 37442132) Front Neurosci. 2019 Mar 15;13:213. (PMID: 30949019) Horm Behav. 2005 Aug;48(2):152-62. (PMID: 16042965) Glia. 2014 Aug;62(8):1284-98. (PMID: 24771617) Pain. 1994 Aug;58(2):157-168. (PMID: 7816484) Iran J Basic Med Sci. 2018 Feb;21(2):138-144. (PMID: 29456810) Eur J Neurosci. 2022 May;55(9-10):2813-2831. (PMID: 33548153) Front Mol Neurosci. 2019 Oct 24;12:248. (PMID: 31708740) Sci Rep. 2017 Nov 28;7(1):16460. (PMID: 29184144) Eur J Pharmacol. 2015 Apr 15;753:66-72. (PMID: 25446562) J Neuroinflammation. 2015 May 20;12:96. (PMID: 25986444) Science. 2022 Jul;377(6601):80-86. (PMID: 35617374) PLoS Biol. 2020 Jul 14;18(7):e3000411. (PMID: 32663221) Pain. 1988 Apr;33(1):87-107. (PMID: 2837713) Neuroscience. 2018 Oct 15;390:119-140. (PMID: 30125685) J Neuroimmunol. 2013 Sep 15;262(1-2):35-45. (PMID: 23870534) Trends Pharmacol Sci. 2009 Jul;30(7):336-40. (PMID: 19523695) Anesth Analg. 2019 Dec;129(6):1733-1741. (PMID: 31743195) Brain Behav Immun. 2008 Jan;22(1):114-23. (PMID: 17919885) Nat Commun. 2020 Sep 8;11(1):4484. (PMID: 32901027) Nat Med. 2023 Jul;29(7):1821-1831. (PMID: 37414898) Nat Rev Neurosci. 2014 Oct;15(10):655-69. (PMID: 25234264) Exp Brain Res. 1997 Feb;113(2):200-6. (PMID: 9063706) Front Cell Neurosci. 2013 Jan 30;7:3. (PMID: 23386810) Neurosci Biobehav Rev. 2015 Jun;53:139-59. (PMID: 25857253) Scand J Pain. 2016 Apr;11:157-162. (PMID: 28850461) Pain. 2005 May;115(1-2):71-83. (PMID: 15836971) |
| فهرسة مساهمة: | Keywords: Anhedonia; Chronic constriction injury; Depression-like behaviour; Hippocampus; Pain-related disability; Radial arm maze |
| المشرفين على المادة: | FYY3R43WGO (Minocycline) |
| تواريخ الأحداث: | Date Created: 20240615 Date Completed: 20240615 Latest Revision: 20240618 |
| رمز التحديث: | 20240618 |
| مُعرف محوري في PubMed: | PMC11180027 |
| DOI: | 10.1007/s11481-024-10132-y |
| PMID: | 38878098 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1557-1904 |
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| DOI: | 10.1007/s11481-024-10132-y |