دورية أكاديمية
Effectiveness of fractional erbium-YAG laser, microneedling, platelet-rich plasma in localized stable vitiligo patients: randomized clinical trial.
| العنوان: | Effectiveness of fractional erbium-YAG laser, microneedling, platelet-rich plasma in localized stable vitiligo patients: randomized clinical trial. |
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| المؤلفون: | Abdel-Hamid S; Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, South Valley University, Qena, Egypt. soher.abdel-hamid@med.svu.edu.eg., Ibrahim HM; Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, South Valley University, Qena, Egypt., Hameed AM; Dermatology, Venereology, and Leprosy Hospital, Qena, Egypt., Hegazy EM; Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, South Valley University, Qena, Egypt. |
| المصدر: | Archives of dermatological research [Arch Dermatol Res] 2024 Jun 15; Vol. 316 (7), pp. 399. Date of Electronic Publication: 2024 Jun 15. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8000462 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-069X (Electronic) Linking ISSN: 03403696 NLM ISO Abbreviation: Arch Dermatol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer Verlag |
| مواضيع طبية MeSH: | Vitiligo*/therapy , Vitiligo*/radiotherapy , Vitiligo*/diagnosis , Platelet-Rich Plasma* , Lasers, Solid-State*/therapeutic use , Skin Pigmentation*/radiation effects , Needles*, Humans ; Female ; Male ; Adult ; Treatment Outcome ; Young Adult ; Middle Aged ; Adolescent ; Dry Needling/methods ; Dry Needling/instrumentation ; Combined Modality Therapy/methods ; Percutaneous Collagen Induction |
| مستخلص: | Vitiligo is considered an autoimmune disease, and its treatment is challenging. We assessed and compared the effect of fractional erbium:yttrium-aluminum-garnet (Er:YAG) laser-assisted delivery of platelet-rich plasma versus microneedling (Mn) with platelet-rich plasma (PRP) in enhancing skin repigmentation in localized stable vitiligo patients. In total, 40 patients with localized stable vitiligo were selected in a random manner into two similar groups (20 each). Group (A) was subjected to fractional Er:YAG laser combined with platelet-rich plasma and Group (B) was subjected to microneedling combined with platelet-rich plasma. The procedure was repeated every 2 weeks for up to 6 months. Each individual was assessed clinically utilizing Vitiligo Area Scoring Index (VASI). Fractional Er:YAG + PRP group achieved better pigmentation100% (excellent 30%, very good 15%, good 30% and satisfactory 25%) which is comparable to Mn + PRP where 80% of cases demonstrate repigmentation (20% very good, 10% good and 50% mild). When comparing the VASI scores for both groups after therapy to the baseline VASI, there was a statistically significant decrease [p = 0.001 for group(A) and 0.003 for group(B)]. Regarding the treatment side effects, there was significantly (p = 0.048) side effects among cases treated with microneedling group(B) (25%) than those fractional Er:Yag laser therapy group(A) (5%). Both forms of therapy demonstrated induction of repigmentation of vitiligo, but fractional Er:YAG laser efficacy is greater when combined with platelet-rich plasma.Clinical trials.gov identifier: NCT05511493. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Er–YAG laser; Microneedling; Platelet-rich plasma; VASI score; Vitiligo |
| سلسلة جزيئية: | ClinicalTrials.gov NCT05511493 |
| تواريخ الأحداث: | Date Created: 20240615 Date Completed: 20240615 Latest Revision: 20240618 |
| رمز التحديث: | 20240618 |
| مُعرف محوري في PubMed: | PMC11180153 |
| DOI: | 10.1007/s00403-024-03035-8 |
| PMID: | 38878236 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-069X |
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| DOI: | 10.1007/s00403-024-03035-8 |