دورية أكاديمية
Biomechanics of annulus fibrosus: Elastic fiber simplification and degenerative impact on damage initiation and propagation.
| العنوان: | Biomechanics of annulus fibrosus: Elastic fiber simplification and degenerative impact on damage initiation and propagation. |
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| المؤلفون: | Sun Z; Jiangsu Key Laboratory of Mechanical Analysis for Infrastructure and Advanced Equipment, School of Civil Engineering, Southeast University, Nanjing, Jiangsu 210096, China., Mi C; Jiangsu Key Laboratory of Mechanical Analysis for Infrastructure and Advanced Equipment, School of Civil Engineering, Southeast University, Nanjing, Jiangsu 210096, China. Electronic address: mi@seu.edu.cn. |
| المصدر: | Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Sep; Vol. 157, pp. 106628. Date of Electronic Publication: 2024 Jun 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101322406 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0180 (Electronic) Linking ISSN: 18780180 NLM ISO Abbreviation: J Mech Behav Biomed Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
| مواضيع طبية MeSH: | Annulus Fibrosus*, Biomechanical Phenomena ; Mechanical Phenomena ; Elastic Tissue ; Intervertebral Disc Degeneration/physiopathology ; Intervertebral Disc Degeneration/pathology ; Stress, Mechanical ; Humans ; Intervertebral Disc ; Models, Biological ; Weight-Bearing |
| مستخلص: | This study addresses three primary objectives related to lumbar intervertebral disc (IVD) biomechanics under ramping quasi-static loading conditions. First, we explore the conditions justifying the simplification of axisymmetric elastic fiber families into single fiber bundles through discretized strain energy functions. Simulations reveal that a concentration factor exceeding 10 allows for a consistent deviation below 10% between simplified and non-simplified responses. Second, we investigate the impact of elastic fibers on the physiological stiffness in IVDs, revealing minimal influence on biological motions but significant effects on degeneration. Lastly, we examine the initiation and progression of annulus fibrosus (AF) damage. Our findings confirm the validity of simplifying elastic fiber families and underscore the necessity of considering elastic fiber damage in biomechanical studies of AF tissues. Elastic fibers contribute to increased biaxial stretch stiffness, and their damage significantly affects the loading capacity of the inner AF. Additionally, degeneration significantly alters the susceptibility to damage in the AF, with specific regions exhibiting higher vulnerability. Damage tends to extend circumferentially and radially, emphasizing the regional variations in collagen and elastic fiber properties. This study offers useful insights for refining biomechanical models, paving the way for a more comprehensive understanding of IVD responses and potential clinical implications. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Annulus fibrosus; Biphasic model; Damage behavior; Multi-level simulation; Physiological motion |
| تواريخ الأحداث: | Date Created: 20240615 Date Completed: 20240728 Latest Revision: 20240728 |
| رمز التحديث: | 20240729 |
| DOI: | 10.1016/j.jmbbm.2024.106628 |
| PMID: | 38878651 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-0180 |
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| DOI: | 10.1016/j.jmbbm.2024.106628 |