دورية أكاديمية
Application of a generic PBK model for beef cattle: Tissue/fluid correlations of paracetamol and NSAIDs.
| العنوان: | Application of a generic PBK model for beef cattle: Tissue/fluid correlations of paracetamol and NSAIDs. |
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| المؤلفون: | Lautz LS; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherlands., Melchers TC; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherlands., Noorlander A; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherlands., Stoopen G; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherlands., Arrizabalaga-Larrañaga A; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherlands. Electronic address: ane.arrizabalagalarranaga@wur.nl. |
| المصدر: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Aug; Vol. 190, pp. 114812. Date of Electronic Publication: 2024 Jun 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Exeter : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Acetaminophen*/urine , Acetaminophen*/blood , Acetaminophen*/pharmacokinetics , Anti-Inflammatory Agents, Non-Steroidal*/blood , Anti-Inflammatory Agents, Non-Steroidal*/analysis, Animals ; Cattle ; Kidney/drug effects ; Kidney/chemistry ; Kidney/metabolism ; Models, Biological ; Meat/analysis ; Tissue Distribution ; Red Meat/analysis |
| مستخلص: | Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and paracetamol can be administered off-label to cattle. Since the use of these veterinary medicines in cattle may pose a public health risk after meat consumption, it is important to translate measured concentrations in urine and tissues into concentrations in meat for human consumption. A generic physiologically-based kinetic (PBK) model for cattle can enable this translation. In this work, a beef cattle PBK model was applied to calculate the relationships between concentrations in different bovine tissues and those were compared to measured concentrations in different matrices. Sixty-seven kidney samples, the corresponding urine and meat samples, and available 19 serum samples were analysed. Overall, 70% of the PBK model predictions are within a 2-fold factor and relationships for kidney/meat, urine/meat, and plasma/meat ratios were established. The conversions of measured kidney concentrations into meat concentrations were mostly within a factor two, while those based on plasma and urine were underpredicted. Based on these ratios, plasma and urine could be used as an appropriate surrogate matrix for a fast, simple in vivo sample screening test under field conditions, such as in local farms and slaughterhouses, to predict a maximum residue level exceedance in meat, reducing the number of test samples. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Food control; In vitro; LC−MS/MS; Liver S9 metabolism; Residues |
| المشرفين على المادة: | 362O9ITL9D (Acetaminophen) 0 (Anti-Inflammatory Agents, Non-Steroidal) |
| تواريخ الأحداث: | Date Created: 20240615 Date Completed: 20240711 Latest Revision: 20240711 |
| رمز التحديث: | 20240712 |
| DOI: | 10.1016/j.fct.2024.114812 |
| PMID: | 38879144 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6351 |
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| DOI: | 10.1016/j.fct.2024.114812 |